MephedroneCandy
Bluelighter
- Joined
- Mar 18, 2022
- Messages
- 88
The serotonin receptors required for the entactogenic effect do not generate much tolerance by themselves. Tolerance of entactogens is given by the depletion of serotonin reserves.
In addition to releasing serotonin and norepinephrine, amiflamine inhibits MAO-A avoiding the degradation of serotonin and giving the same effects as MDMA by releasing much less serotonin.
In addition, a useful peculiarity of the molecule is that of being selective for the MAO-A present in the surroundings of the serotonergic axons, not increasing the concentration of norepinephrine very much. This is a good thing because when I tried to inhibit MAOA with a selective inhibitor (methylene blue) I got effects that were attributable to excessive increases in norepinephrine relative to serotonin (although the serotonergic effects were also increased). In fact, MAO-A degrades much more norepinephrine than it does serotonin.
All this I think makes this molecule an excellent entactogen without too much tolerance or hangovers. Definitely on the list of molecules to try.
It must also be said that combining SRAs and MAOIs can cause serotonin syndrome, but since here the effects are all obtained with just one molecule, the risks are less since it is necessary to adjust the dosage of a single molecule, instead of finding the right ratios and the molecules with a compatible half-life between them.
In addition to releasing serotonin and norepinephrine, amiflamine inhibits MAO-A avoiding the degradation of serotonin and giving the same effects as MDMA by releasing much less serotonin.
In addition, a useful peculiarity of the molecule is that of being selective for the MAO-A present in the surroundings of the serotonergic axons, not increasing the concentration of norepinephrine very much. This is a good thing because when I tried to inhibit MAOA with a selective inhibitor (methylene blue) I got effects that were attributable to excessive increases in norepinephrine relative to serotonin (although the serotonergic effects were also increased). In fact, MAO-A degrades much more norepinephrine than it does serotonin.
All this I think makes this molecule an excellent entactogen without too much tolerance or hangovers. Definitely on the list of molecules to try.
It must also be said that combining SRAs and MAOIs can cause serotonin syndrome, but since here the effects are all obtained with just one molecule, the risks are less since it is necessary to adjust the dosage of a single molecule, instead of finding the right ratios and the molecules with a compatible half-life between them.