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Albert Hofmann

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Albert Hofmann

The role LSD has played in my spiritual development

by Albert Hofmann

After my first experiences with LSD, the question arose for me:

Which is true: the picture of the world as we perceive it with our everyday consciousness, or the overwhelming image we perceive under the influence of entheogens?

This caused me to analyze what we know about the mechanism of perceiving reality.

Perception presupposes a subject that perceives, and the object that is perceived. In human relations the subject that perceives is the individual human being, more exactly his consciousness, and the object perceived is the outer material world.

It is of the greatest importance to be aware of the fundamental fact that the outer world consists objectively of nothing more than matter and energy.

In order to make conspicuous the mechanism of our experiencing reality, I have chosen a metaphor from television. The material world functions as transmitter, emanates optical, acoustical, gustatory, olfactory, and tactile signals that are received by the antennae, by our sensory organs, eyes, ears, tongue, nose, and skin and are conducted from there to the corresponding center in the brain to the receiver. There these energetic and material signals are transformed into the spiritual phenomena of seeing, hearing, tasting, smelling, and touching. One does not know how this transformation of material and energetic impulses into the psychic dimension of perception takes place. It includes the mystery of the connection between the material and the spiritual world.

The transmitter-receiver metaphor of reality makes evident that the picture of the outer world comes into existence inside, in the consciousness of the individual.

This fundamental fact signifies that the screen on which the colorful world is perceived is not in the outer but in the inner space of every human being. There are no colors, no sounds, no taste, no odors in the outer world. Everyone carries within himself his own personal image of the world, an image created by his private receiver. There is no common screen outside. This makes us fully aware of the cosmogenic (world-creating) power invested in every human.

Before making use of these considerations to explain the ability of LSD and the other entheogens to change the experience of reality, our knowledge about the essence of consciousness must be reviewed.

Consciousness defies a scientific definition and explanation; for it is what is needed to contemplate what consciousness is. It can only be circumscribed as being the receptive and creative center of the spiritual ego, which has the faculties of perceiving, thinking, and feeling, and which is the seat of memory.

It is of fundamental importance to be aware of how consciousness originates and develops.

The newborn human possesses solely the faculty of perceiving, or more correctly, is this mystic nucleus of life. He owns, to use again the metaphor of television, a blank videocassette, where the incoming stimuli from the outer world are transformed into images and sensations that can then be stored in the memory, providing the groundwork for thinking. Without these signals from outside, no consciousness could develop.

There is common consent that the evolution of mankind is paralleled by the increase and expansion of consciousness. From the described process of how consciousness originates and develops, it becomes evident that its growth depends on its faculty of perception.

Therefore every means of improving this faculty should be used.

The characteristics of entheogens, and their faculty to improve sensory perception, makes them inestimable aids in the process of expanding consciousness.

It was LSD, the most potent entheogen, that, to use Blake's famous line, cleansed my doors of perception and made me see everything as it is, infinite.

In my childhood I experienced spontaneously some of those blissful moments when the world appeared suddenly in a new brilliant light, and I had the feeling of being included in its wonder and indescribable beauty. These moments remained in my memory as extraordinary experiences of untold happiness, but only after the discovery of LSD did I grasp their meaning and existential importance.

As mentioned at the beginning of this short essay, it was my experiences with LSD that caused me to think about the essence of reality. The insights I received, as described, increased my astonishment about the wonder of existence, of which we become conscious in enlightened moments.​
 
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How LSD Originated

by Albert Hofmann

There are experiences that most of us are hesitant to speak about, because they do not conform to everyday reality and defy rational explanation. These are not particular external occurrences, but rather events of our inner lives, which are generally dismissed as figments of the imagination and barred from our memory. Suddenly, the familiar view of our surroundings is transformed in a strange, delightful, or alarming way: it appears to us in a new light, takes on a special meaning. Such an experience can be as light and fleeting as a breath of air, or it can imprint itself deeply upon our minds.

One enchantment of that kind, which I experienced in childhood, has remained remarkably vivid in my memory ever since. It happened on a May morning—I have forgotten the year—but I can still point to the exact spot where it occurred, on a forest path on Martinsberg above Baden, Switzerland. As I strolled through the freshly greened woods filled with bird song and lit up by the morning sun, all at once everything appeared in an uncommonly clear light. Was this something I had simply failed to notice before? Was I suddenly discovering the spring forest as it actually looked? It shone with the most beautiful radiance, speaking to the heart, as though it wanted to encompass me in its majesty. I was filled with an indescribable sensation of joy, oneness, and blissful security.

I have no idea how long I stood there spellbound. But I recall the anxious concern I felt as the radiance slowly dissolved and I hiked on: how could a vision that was so real and convincing, so directly and deeply felt—how could it end so soon? And how could I tell anyone about it, as my overflowing joy compelled me to do, since I knew there were no words to describe what I had seen? It seemed strange that I, as a child, had seen something so marvelous, something that adults obviously did not perceive - for I had never heard them mention it.

While still a child, I experienced several more of these deeply euphoric moments on my rambles through forest and meadow. It was these experiences that shaped the main outlines of my world view and convinced me of the existence of a miraculous, powerful, unfathomable reality that was hidden from everyday sight.

I was often troubled in those days, wondering if I would ever, as an adult, be able to communicate these experiences; whether I would have the chance to depict my visions in poetry or paintings. But knowing that I was not cut out to be a poet or artist, I assumed I would have to keep these experiences to myself, important as they were to me.

Unexpectedly—though scarcely by chance—much later, in middle age, a link was established between my profession and these visionary experiences from childhood.

Because I wanted to gain insight into the structure and essence of matter, I became a research chemist. Intrigued by the plant world since early childhood, I chose to specialize in research on the constituents of medicinal plants. In the course of this career I was led to the psychoactive, hallucination-causing substances, which under certain conditions can evoke visionary states similar to the spontaneous experiences just described. The most important of these hallucinogenic substances has come to be known as LSD.

Hallucinogens, as active compounds of considerable scientific interest, have gained entry into medicinal research, biology, and psychiatry, and later—especially LSD also obtained wide diffusion in the drug culture.

In studying the literature connected with my work, I became aware of the great universal significance of visionary experience. It plays a dominant role, not only in mysticism and the history of religion, but also in the creative process in art, literature, and science. More recent investigations have shown that many persons also have visionary experiences in daily life, though most of us fail to recognize their meaning and value. Mystical experiences, like those that marked my childhood, are apparently far from rare.

There is today a widespread striving for mystical experience, for visionary breakthroughs to a deeper, more comprehensive reality than that perceived by our rational, everyday consciousness. Efforts to transcend our materialistic world view are being made in various ways, not only by the adherents to Eastern religious movements, but also by professional psychiatrists, who are adopting such profound spiritual experiences as a basic therapeutic principle.

I share the belief of many of my contemporaries that the spiritual crisis pervading all spheres of Western industrial society can be remedied only by a change in our world view. We shall have to shift from the materialistic, dualistic belief that people and their environment are separate, toward a new consciousness of an all-encompassing reality, which embraces the experiencing ego, a reality in which people feel their oneness with animate nature and all of creation.

Everything that can contribute to such a fundamental alteration in our perception of reality must therefore command earnest attention. Foremost among such approaches are the various methods of meditation, either in a religious or a secular context, which aim to deepen the consciousness of reality by way of a total mystical experience. Another important, but still controversial, path to the same goal is the use of the consciousness-altering properties of hallucinogenic psychopharmaceuticals. LSD finds such anapplication in medicine, by helping patients in psychoanalysis and psychotherapy to perceive their problems in their true significance.

Deliberate provocation of mystical experience, particularly by LSD and related hallucinogens, in contrast to spontaneous visionary experiences, entails dangers that must not be underestimated. Practitioners must take into account the peculiar effects of these substances, namely their ability to influence our consciousness, the innermost essence of our being. The history of LSD to date amply demonstrates the catastrophic consequences that can ensue when its profound effect is misjudged and the substance is mistaken for a pleasure drug. Special internal and external advance preparations are required; with them, an LSD experiment can become a meaningful experience. Wrong and inappropriate use has caused LSD to become my problem child.

It is my desire in this book to give a comprehensive picture of LSD, its origin, its effects, and its dangers, in order to guard against increasing abuse of this extraordinary drug. I hope thereby to emphasize possible uses of LSD that are compatible with its characteristic action. I believe that if people would learn to use LSD's vision-inducing capability more wisely, under suitable conditions, in medical practice and in conjunction with meditation, then in the future this problem child could become a wonder child.

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Time and again I hear or read that LSD was discovered by accident. This is only partly true. LSD came into being within a systematic research program, and the "accident" did not occur until much later: when LSD was already five years old, I happened to experience its unforeseeable effects in my own body—or rather, in my own mind.

Looking back over my professional career to trace the influential events and decisions that eventually steered my work toward the synthesis of LSD, I realize that the most decisive step was my choice of employment upon completion of my chemistry studies. If that decision had been different, then this substance, which has become known the world over, might never have been created. In order to tell the story of the origin of LSD, then, I must also touch briefly on my career as a chemist, since the two developments are inextricably interrelated.

In the spring of 1929, on concluding my chemistry studies at the University of Zurich, I joined the Sandoz Company's pharmaceutical-chemical research laboratory in Basel, as a co-worker with Professor Arthur Stoll, founder and director of the pharmaceutical department. I chose this position because it afforded me the opportunity to work on natural products, whereas two other job offers from chemical firms in Basel had involved work in the field of synthetic chemistry.

First Chemical Explorations

My doctoral work at Zurich under Professor Paul Karrer had already given me one chance to pursue my interest in plant and animal chemistry. Making use of the gastrointestinal juice of the vineyard snail, I accomplished the enzymatic degradation of chitin, the structural material of which the shells, wings, and claws of insects, crustaceans, and other lower animals are composed. I was able to derive the chemical structure of chitin from the cleavage product, a nitrogen-containing sugar, obtained by this degradation. Chitin turned out to be an analogue of cellulose, the structural material of plants. This important result, obtained after only three months of research, led to a doctoral thesis rated "with distinction."

When I joined the Sandoz firm, the staff of the pharmaceutical-chemical department was still rather modest in number. Four chemists with doctoral degrees worked in research, three in production.

In Stoll's laboratory I found employment that completely agreed with me as a research chemist. The objective that Professor Stoll had set for his pharmaceutical-chemical research laboratories was to isolate the active principles (i.e., the effective constituents) of known medicinal plants to produce pure specimens of these substances. This is particularly important in the case of medicinal plants whose active principles are unstable, or whose potency is subject to great variation, which makes an exact dosage difficult. But if the active principle is available in pure form, it becomes possible to manufacture a stable pharmaceutical preparation, exactly quantifiable by weight. With this in mind, Professor Stoll had elected to study plant substances of recognized value such as the substances from foxglove (Digitalis), Mediterranean squill (Scilla maritima), and ergot of rye (Claviceps purpurea or Secale cornutum), which, owning to their instability and uncertain dosage, nevertheless, had been little used in medicine.

My first years in the Sandoz laboratories were devoted almost exclusively to studying the active principles of Mediterranean squill. Dr. Walter Kreis, one of Professor Stoll's earliest associates, launched me in this field of research. The most important constituents of Mediterranean squill already existed in pure form. Their active agents, as well as those of woolly foxglove (Digitalis lanata), had been isolated and purified, chiefly by Dr. Kreis, with extraordinary skill.

The active principles of Mediterranean squill belong to the group of cardioactive glycosides (glycoside = sugar-containing substance) and serve, as do those of foxglove, in the treatment of cardiac insufficiency. The cardiac glycosides are extremely active substances. Because the therapeutic and the toxic doses differ so little, it becomes especially important here to have an exact dosage, based on pure compounds.

At the beginning of my investigations, a pharmaceutical preparation with Scilla glycosides had already been introduced into therapeutics by Sandoz; however, the chemical structure of these active compounds, with the exception of the sugar portion, remained largely unknown.

My main contribution to the Scilla research, in which I participated with enthusiasm, was to elucidate the chemical structure of the common nucleus of Scilla glycosides, showing on the one hand their differences from the Digitalis glycosides, and on the other hand their close structural relationship with the toxic principles isolated from skin glands of toads. In 1935, these studies were temporarily concluded.

Looking for a new field of research, I asked Professor Stoll to let me continue the investigations on the alkaloids of ergot, which he had begun in 1917 and which had led directly to the isolation of ergotamine in 1918. Ergotamine, discovered by Stoll, was the first ergot alkaloid obtained in pure chemical form. Although ergotamine quickly took a significant place in therapeutics (under the trade name Gynergen) as a hemostatic remedy in obstetrics and as a medicament in the treatment of migraine, chemical research on ergot in the Sandoz laboratories was abandoned after the isolation of ergotamine and the determination of its empirical formula. Meanwhile, at the beginning of the thirties, English and American laboratories had begun to determine the chemical structure of ergot alkaloids. They had also discovered a new, water-soluble ergot alkaloid, which could likewise be isolated from the mother liquor of ergotamine production. So I thought it was high time that Sandoz resumed chemical research on ergot alkaloids, unless we wanted to risk losing our leading role in a field of medicinal research, which was already becoming so important.

Professor Stoll granted my request, with some misgivings: "I must warn you of the difficulties you face in working with ergot alkaloids. These are-exceedingly sensitive, easily decomposed substances, less stable than any of the compounds you have investigated in the cardiac glycoside field. But you are welcome to try."

And so the switches were thrown, and I found myself engaged in a field of study that would become the main theme of my professional career. I have never forgotten the creative joy, the eager anticipation I felt in embarking on the study of ergot alkaloids, at that time a relatively uncharted field of research.

Ergot

It may be helpful here to give some background information about ergot itself. [For further information on ergot, readers should refer to the monographs of G. Berger, Ergot and Ergotism (Gurney and Jackson, London, 1931 ) and A. Hofmann, Die Mutterkornalkaloide (F. Enke Verlag, Stuttgart, 1964). The former is a classical presentation of the history of the drug, while the latter emphasizes the chemical aspects.]

It is produced by a lower fungus (Claviceps purpurea) that grows parasitically on rye and, to a lesser extent, on other species of grain and on wild grasses. Kernels infested with this fungus develop into light-brown to violet-brown curved pegs (sclerotia) that push forth from the husk in place of normal grains. Ergot is described botanically as a sclerotium, the form that the ergot fungus takes in winter. Ergot of rye (Secale cornutum) is the variety used medicinally.

Ergot, more than any other drug, has a fascinating history, in the course of which its role and meaning have been reversed: once dreaded as a poison, in the course of time it has changed to a rich storehouse of valuable remedies. Ergot first appeared on the stage of history in the early Middle Ages, as the cause of outbreaks of mass poisonings affecting thousands of persons at a time. The illness, whose connection with ergot was for a long time obscure, appeared in two characteristic forms, one gangrenous (ergotismus gangraenosus) and the other convulsive (ergotismus convulsivus). Popular names for ergotism—such as "mal des ardents," "ignis sacer," "heiliges Feuer," or "St. Anthony's fire"—refer to the gangrenous form of the disease. The patron saint of ergotism victims was St. Anthony, and it was primarily the Order of St. Anthony that treated these patients.

Until recent times, epidemic-like outbreaks of ergot poisoning have been recorded in most European countries including certain areas of Russia. With progress in agriculture, and since the realization, in the seventeenth century, that ergot-containing bread was the cause, the frequency and extent of ergotism epidemics diminished considerably. The last great epidemic occurred in certain areas of southern Russia in the years 1926-27. [The mass poisoning in the southern French city of Pont-St. Esprit in the year 1951, which many writers have attributed to ergot-containing bread, actually had nothing to do with ergotism. It rather involved poisoning by an organic mercury compound that was utilized for disinfecting seed.]

The first mention of a medicinal use of ergot, namely as an ecbolic (a medicament to precipitate childbirth), is found in the herbal of the Frankfurt city physician Adam Lonitzer (Lonicerus) in the year 1582. Although ergot, as Lonitzer stated, had been used since olden times by midwives, it was not until 1808 that this drug gained entry into academic medicine, on the strength of a work by the American physician John Stearns entitled Account of the Putvis Parturiens, a Remedy for Quickening Childbirth. The use of ergot as an ecbolic did not, however, endure. Practitioners became aware quite early of the great danger to the child, owing primarily to the uncertainty of dosage, which when too high led to uterine spasms. From then on, the use of ergot in obstetrics was confined to stopping postpartum hemorrhage (bleeding after childbirth).

It was not until ergot's recognition in various pharmacopoeias during the first half of the nineteenth century that the first steps were taken toward isolating the active principles of the drug. However, of all the researchers who assayed this problem during the first hundred years, not one succeeded in identifying the actual substances responsible for the therapeutic activity. In 1907, the Englishmen G. Barger and F. H. Carr were the first to isolate an active alkaloidal preparation, which they named ergotoxine because it produced more of the toxic than therapeutic properties of ergot. (This preparation was not homogeneous, but rather a mixture of several alkaloids, as I was able to show thirty-five years later.) Nevertheless, the pharmacologist H. H. Dale discovered that ergotoxine, besides the uterotonic effect, also had an antagonistic activity on adrenaline in the autonomic nervous system that could lead to the therapeutic use of ergot alkaloids. Only with the isolation of ergotamine by A. Stoll (as mentioned previously) did an ergot alkaloid find entry and widespread use in therapeutics.

The early 1930s brought a new era in ergot research, beginning with the determination of the chemical structure of ergot alkaloids, as mentioned, in English and American laboratories. By chemical cleavage, W. A. Jacobs and L. C. Craig of the Rockefeller Institute of New York succeeded in isolating and characterizing the nucleus common to all ergot alkaloids. They named it lysergic acid. Then came a major development, both for chemistry and for medicine: the isolation of the specifically uterotonic, hemostatic principle of ergot, which was published simultaneously and quite independently by four institutions, including the Sandoz laboratories. The substance, an alkaloid of comparatively simple structure, was named ergobasine (syn. ergometrine, ergonovine) by A. Stoll and E. Burckhardt. By the chemical degradation of ergobasine, W. A. Jacobs and L. C. Craig obtained lysergic acid and the amino alcohol propanolamine as cleavage products.

I set as my first goal the problem of preparing this alkaloid synthetically, through chemical linking of the two components of ergobasine, lysergic acid and propanolamine (see structural formulas in the appendix).

The lysergic acid necessary for these studies had to be obtained by chemical cleavage of some other ergot alkaloid. Since only ergotamine was available as a pure alkaloid, and was already being produced in kilogram quantities in the pharmaceutical production department, I chose this alkaloid as the starting material for my work. I set about obtaining 0.5 gm of ergotamine from the ergot production people. When I sent the internal requisition form to Professor Stoll for his countersignature, he appeared in my laboratory and reproved me: "If you want to work with ergot alkaloids, you will have to familiarize yourself with the techniques of microchemistry. I can't have you consuming such a large amount of my expensive ergotamine for your experiments."

The ergot production department, besides using ergot of Swiss origin to obtain ergotamine, also dealt with Portuguese ergot, which yielded an amorphous alkaloidal preparation that corresponded to the aforementioned ergotoxine first produced by Barger and Carr. I decided to use this less expensive material for the preparation of lysergic acid.

The alkaloid obtained from the production department had to be purified further, before it would be suitable for cleavage to lysergic acid. Observations made during the purification process led me to think that ergotoxine could be a mixture of several alkaloids, rather than one homogeneous alkaloid. I will speak later of the far-reaching sequelae of these observations.

Here I must digress briefly to describe the working conditions and techniques that prevailed in those days. These remarks may be of interest to the present generation of research chemists in industry, who are accustomed to far better conditions.

We were very frugal. Individual laboratories were considered a rare extravagance. During the first six years of my employment with Sandoz, I shared a laboratory with two colleagues. We three chemists, plus an assistant each, worked in the same room on three different fields: Dr. Kreiss on cardiac glycosides; Dr. Wiedemann, who joined Sandoz around the same time as I, on the leaf pigment chlorophyll; and I ultimately on ergot alkaloids. The laboratory was equipped with two fume hoods (compartments supplied with outlets), providing less than effective ventilation by gas flames. When we requested that these hoods be equipped with ventilators, our chief refused on the ground that ventilation by gas flame had sufficed in Willstatter's laboratory.

During the last years of World War I, Professor Stoll had been an assistant in Berlin and Munich to the world-famous chemist and Nobel laureate Professor Richard Willstatter, and with him had conducted the fundamental investigations on chlorophyll and the assimilation of carbon dioxide. There was scarcely a scientific discussion with Professor Stoll in which he did not mention his revered teacher Professor Willstatter and his work in Willstatter's laboratory.

The working techniques available to chemists in the field of organic chemistry at that time (the beginning of the thirties) were essentially the same as those employed by Justus von Liebig a hundred years earlier. The most important development achieved since then was the introduction of microanalysis by B. Pregl, which made it possible to ascertain the elemental composition of a compound with only a few milligrams of specimen, whereas earlier a few centigrams were needed. Of the other physical-chemical techniques at the disposal of the chemist today—techniques which have changed his way of working, making it faster and more effective, and created entirely new possibilities, above all for the elucidation of structure - none yet existed in those days.

For the investigations of Scilla glycosides and the first studies in the ergot field, I still used the old separation and purification techniques from Liebig's day: fractional extraction, fractional precipitation, fractional crystallization, and the like. The introduction of column chromatography, the first important step in modern laboratory technique, was of great value to me only in later investigations. For structure determination, which today can be conducted rapidly and elegantly with the help of spectroscopic methods (UV, IR, NMR) and X-ray crystallography, we had to rely, in the first fundamental ergot studies, entirely on the old laborious methods of chemical degradation and derivatization.

Lysergic Acid and its Derivatives

Lysergic acid proved to be a rather unstable substance, and its rebonding with basic radicals posed difficulties. In the technique known as Curtius' Synthesis, I ultimately found a process that proved useful for combining lysergic acid with amines. With this method I produced a great number of lysergic acid compounds. By combining lysergic acid with the amino alcohol propanolamine, I obtained a compound that was identical to the natural ergot alkaloid ergobasine. With that, the first synthesis—that is, artificial production—of an ergot alkaloid was accomplished. This was not only of scientific interest, as confirmation of the chemical structure of ergobasine, but also of practical significance, because ergobasine, the specifically uterotonic, hemostatic principle, is present in ergot only in very trifling quantities. With this synthesis, the other alkaloids existing abundantly in ergot could now be converted to ergobasine, which was valuable in obstetrics.

After this first success in the ergot field, my investigations went forward on two fronts. First, I attempted to improve the pharmacological properties of ergobasine by variations of its amino alcohol radical. My colleague Dr. J. Peyer and I developed a process for the economical production of propanolamine and other amino alcohols. Indeed, by substitution of the propanolamine contained in ergobasine with the amino alcohol butanolamine, an active principle was obtained that even surpassed the natural alkaloid in its therapeutic properties. This improved ergobasine has found worldwide application as a dependable uterotonic, hemostatic remedy under the trade name Methergine, and is today the leading medicament for this indication in obstetrics.

I further employed my synthetic procedure to produce new lysergic acid compounds for which uterotonic activity was not prominent, but from which, on the basis of their chemical structure, other types of interesting pharmacological properties could be expected. In 1938, I produced the twenty-fifth substance in this series of lysergic acid derivatives: lysergic acid diethylamide, abbreviated LSD-25 (Lyserg-säure-diäthylamid) for laboratory usage.

I had planned the synthesis of this compound with the intention of obtaining a circulatory and respiratory stimulant (an analeptic). Such stimulating properties could be expected for lysergic acid diethylamide, because it shows similarity in chemical structure to the analeptic already known at that time, namely nicotinic acid diethylamide (Coramine). During the testing of LSD-25 in the pharmacological department of Sandoz, whose director at the time was Professor Ernst Rothlin, a strong effect on the uterus was established. It amounted to some 70 percent of the activity of ergobasine. The research report also noted, in passing, that the experimental animals became restless during the narcosis. The new substance, however, aroused no special interest in our pharmacologists and physicians; testing was therefore discontinued.

For the next five years, nothing more was heard of the substance LSD-25. Meanwhile, my work in the ergot field advanced further in other areas. Through the purification of ergotoxine, the starting material for lysergic acid, I obtained, as already mentioned, the impression that this alkaloidal preparation was not homogeneous, but was rather a mixture of different substances. This doubt as to the homogeneity of ergotoxine was reinforced when in its hydrogenation two distinctly different hydrogenation products were obtained, whereas the homogeneous alkaloid ergotamine under the same condition yielded only a single hydrogenation product (hydrogenation = introduction of hydrogen). Extended, systematic analytical investigations of the supposed ergotoxine mixture led ultimately to the separation of this alkaloidal preparation into three homogeneous components. One of the three chemically homogeneous ergotoxine alkaloids proved to be identical with an alkaloid isolated shortly before in the production department, which A. Stoll and E. Burckhardt had named ergocristine. The other two alkaloids were both new. The first I named ergocornine; and for the second, the last to be isolated, which had long remained hidden in the mother liquor, I chose the name ergokryptine (kryptos = hidden). Later it was found that ergokryptine occurs in two isomeric forms, which were differentiated as alfa- and beta-ergokryptine.

The solution of the ergotoxine problem was not merely scientifically interesting, but also had great practical significance. A valuable remedy arose from it. The three hydrogenated ergotoxine alkaloids that I produced in the course of these investigations, dihydroergocristine, dihydroergokryptine, and dihydroergocornine, displayed medicinally useful properties during testing by Professor Rothlin in the pharmacological department. From these three substances, the pharmaceutical preparation Hydergine was developed, a medicament for improvement of peripheral circulation and cerebral function in the control of geriatric disorders. Hydergine has proven to be an effective remedy in geriatrics for these indications. Today it is Sandoz's most important pharmaceutical product.

Dihydroergotamine, which I likewise produced in the course of these investigations, has also found application in therapeutics as a circulation- and blood-pressure-stabilizing medicament, under the trade name Dihydergot.

While today research on important projects is almost exclusively carried out as teamwork, the investigations on ergot alkaloids described above were conducted by myself alone. Even the further chemical steps in the evolution of commercial preparations remained in my hands—that is, the preparation of larger specimens for the clinical trials, and finally the perfection of the first procedures for mass production of Methergine, Hydergine, and Dihydergot. This even included the analytical controls for the development of the first galenical forms of these three preparations: the ampoules, liquid solutions, and tablets. My aides at that time included a laboratory assistant, a laboratory helper, and later in addition a second laboratory assistant and a chemical technician.

Discovery of the Psychic Effects of LSD

The solution of the ergotoxine problem had led to fruitful results, described here only briefly, and had opened up further avenues of research. And yet I could not forget the relatively uninteresting LSD-25. A peculiar presentiment—the feeling that this substance could possess properties other than those established in the first investigations—induced me, five years after the first synthesis, to produce LSD-25 once again so that a sample could be given to the pharmacological department for further tests. This was quite unusual; experimental substances, as a rule, were definitely stricken from the research program if once found to be lacking in pharmacological interest.

Nevertheless, in the spring of 1943, I repeated the synthesis of LSD-25. As in the first synthesis, this involved the production of only a few centigrams of the compound.

In the final step of the synthesis, during the purification and crystallization of lysergic acid diethylamide in the form of a tartrate (tartaric acid salt), I was interrupted in my work by unusual sensations. The following description of this incident comes from the report that I sent at the time to Professor Stoll:

Last Friday, April 16,1943, I was forced to interrupt my work in the laboratory in the middle of the afternoon and proceed home, being affected by a remarkable restlessness, combined with a slight dizziness. At home I lay down and sank into a not unpleasant intoxicated-like condition, characterized by an extremely stimulated imagination. In a dreamlike state, with eyes closed (I found the daylight to be unpleasantly glaring), I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors. After some two hours this condition faded away.

This was, altogether, a remarkable experience—both in its sudden onset and its extraordinary course. It seemed to have resulted from some external toxic influence; I surmised a connection with the substance I had been working with at the time, lysergic acid diethylamide tartrate. But this led to another question: how had I managed to absorb this material? Because of the known toxicity of ergot substances, I always maintained meticulously neat work habits. Possibly a bit of the LSD solution had contacted my fingertips during crystallization, and a trace of the substance was absorbed through the skin. If LSD-25 had indeed been the cause of this bizarre experience, then it must be a substance of extraordinary potency. There seemed to be only one way of getting to the bottom of this. I decided on a self-experiment.

Exercising extreme caution, I began the planned series of experiments with the smallest quantity that could be expected to produce some effect, considering the activity of the ergot alkaloids known at the time: namely, 0.25 mg (mg = milligram = one thousandth of a gram) of lysergic acid diethylamide tartrate. Quoted below is the entry for this experiment in my laboratory journal of April 19, 1943.


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Self-Experiments

4/19/43 16:20:
0.5 cc of 1/2 promil aqueous solution of diethylamide tartrate orally = 0.25 mg tartrate. Taken diluted with about 10 cc water. Tasteless.
17:00: Beginning dizziness, feeling of anxiety, visual distortions, symptoms of paralysis, desire to laugh. Home by bicycle.
From 18:00- ca.20:00 most severe crisis.

Here the notes in my laboratory journal cease. I was able to write the last words only with great effort. By now it was already clear to me that LSD had been the cause of the remarkable experience of the previous Friday, for the altered perceptions were of the same type as before, only much more intense. I had to struggle to speak intelligibly. I asked my laboratory assistant, who was informed of the self-experiment, to escort me home. We went by bicycle, no automobile being available because of wartime restrictions on their use. On the way home, my condition began to assume threatening forms.

Everything in my field of vision wavered and was distorted as if seen in a curved mirror. I also had the sensation of being unable to move from the spot. Nevertheless, my assistant later told me that we had traveled very rapidly. Finally, we arrived at home safe and sound, and I was just barely capable of asking my companion to summon our family doctor and request milk from the neighbors.

In spite of my delirious, bewildered condition, I had brief periods of clear and effective thinking—and chose milk as a nonspecific antidote for poisoning.

The dizziness and sensation of fainting became so strong at times that I could no longer hold myself erect, and had to lie down on a sofa. My surroundings had now transformed themselves in more terrifying ways. Everything in the room spun around, and the familiar objects and pieces of furniture assumed grotesque, threatening forms. They were in continuous motion, animated, as if driven by an inner restlessness. The lady next door, whom I scarcely recognized, brought me milk—in the course of the evening I drank more than two liters. She was no longer Mrs. R., but rather a malevolent, insidious witch with a colored mask.

Even worse than these demonic transformations of the outer world, were the alterations that I perceived in myself, in my inner being. Every exertion of my will, every attempt to put an end to the disintegration of the outer world and the dissolution of my ego, seemed to be wasted effort. A demon had invaded me, had taken possession of my body, mind, and soul. I jumped up and screamed, trying to free myself from him, but then sank down again and lay helpless on the sofa. The substance, with which I had wanted to experiment, had vanquished me. It was the demon that scornfully triumphed over my will. I was seized by the dreadful fear of going insane. I was taken to another world, another place, another time. My body seemed to be without sensation, lifeless, strange.

Was I dying? Was this the transition? At times I believed myself to be outside my body, and then perceived clearly, as an outside observer, the complete tragedy of my situation. I had not even taken leave of my family (my wife, with our three children had traveled that day to visit her parents, in Lucerne). Would they ever understand that I had not experimented thoughtlessly, irresponsibly, but rather with the utmost caution, and that such a result was in no way foreseeable? My fear and despair intensified, not only because a young family should lose its father, but also because I dreaded leaving my chemical research work, which meant so much to me, unfinished in the midst of fruitful, promising development. Another reflection took shape, an idea full of bitter irony: if I was now forced to leave this world prematurely, it was because of this Iysergic acid diethylamide that I myself had brought forth into the world.

By the time the doctor arrived, the climax of my despondent condition had already passed. My laboratory assistant informed him about my self-experiment, as I myself was not yet able to formulate a coherent sentence. He shook his head in perplexity, after my attempts to describe the mortal danger that threatened my body. He could detect no abnormal symptoms other than extremely dilated pupils. Pulse, blood pressure, breathing were all normal. He saw no reason to prescribe any medication. Instead he conveyed me to my bed and stood watch over me. Slowly I came back from a weird, unfamiliar world to reassuring everyday reality. The horror softened and gave way to a feeling of good fortune and gratitude, the more normal perceptions and thoughts returned, and I became more confident that the danger of insanity was conclusively past.

Now, little by little I could begin to enjoy the unprecedented colors and plays of shapes that persisted behind my closed eyes. Kaleidoscopic, fantastic images surged in on me, alternating, variegated, opening and then closing themselves in circles and spirals, exploding in colored fountains, rearranging and hybridizing themselves in constant flux. It was particularly remarkable how every acoustic perception, such as the sound of a door handle or a passing automobile, became transformed into optical perceptions. Every sound generated a vividly changing image, with its own consistent form and color.

Late in the evening my wife returned from Lucerne. Someone had informed her by telephone that I was suffering a mysterious breakdown. She had returned home at once, leaving the children behind with her parents. By now, I had recovered myself sufficiently to tell her what had happened.

Exhausted, I then slept, to awake next morning refreshed, with a clear head, though still somewhat tired physically. A sensation of well-being and renewed life flowed through me. Breakfast tasted delicious and gave me extraordinary pleasure. When I later walked out into the garden, in which the sun shone now after a spring rain, everything glistened and sparkled in a fresh light. The world was as if newly created. All my senses vibrated in a condition of highest sensitivity, which persisted for the entire day.

This self-experiment showed that LSD-25 behaved as a psychoactive substance with extraordinary properties and potency. There was to my knowledge no other known substance that evoked such profound psychic effects in such extremely low doses, that caused such dramatic changes in human consciousness and our experience of the inner and outer world.

What seemed even more significant was that I could remember the experience of LSD inebriation in every detail. This could only mean that the conscious recording function was not interrupted, even in the climax of the LSD experience, despite the profound breakdown of the normal world view. For the entire duration of the experiment, I had even been aware of participating in an experiment, but despite this recognition of my condition, I could not, with every exertion of my will, shake off the LSD world. Everything was experienced as completely real, as alarming reality; alarming, because the picture of the other, familiar everyday reality was still fully preserved in the memory for comparison. Another surprising aspect of LSD was its ability to produce such a far-reaching, powerful state of inebriation without leaving a hangover. Quite the contrary, on the day after the LSD experiment I felt myself to be, as already described, in excellent physical and mental condition.

I was aware that LSD, a new active compound with such properties, would have to be of use in pharmacology, in neurology, and especially in psychiatry, and that it would attract the interest of concerned specialists. But at that time I had no inkling that the new substance would also come to be used beyond medical science, as an inebriant in the drug scene. Since my self-experiment had revealed LSD in its terrifying, demonic aspect, the last thing I could have expected was that this substance could ever find application as anything approaching a pleasure drug. I failed, moreover, to recognize the meaningful connection between LSD inebriation and spontaneous visionary experience until much later, after further experiments, which were carried out with far lower doses and under different conditions.

The next day I wrote to Professor Stoll the above-mentioned report about my extraordinary experience with LSD-25 and sent a copy to the director of the pharmacological department, Professor Rothlin.

As expected, the first reaction was incredulous astonishment. Instantly a telephone call came from the management; Professor Stoll asked: "Are you certain you made no mistake in the weighing? Is the stated dose really correct?" Professor Rothlin also called, asking the same question. I was certain of this point, for I had executed the weighing and dosage with my own hands. Yet their doubts were justified to some extent, for until then no known substance had displayed even the slightest psychic effect in fraction-of-a-milligram doses. An active compound of such potency seemed almost unbelievable.

Professor Rothlin himself and two of his colleagues were the first to repeat my experiment, with only one-third of the dose I had utilized. But even at that level, the effects were still extremely impressive, and quite fantastic. All doubts about the statements in my report were eliminated.

 
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An interview with Albert Hofmann

by David Jay Brown, M.A [2008]

This is a brief interview that I did with Albert Hofmann, shortly after his 100th birthday.

What originally inspired your interest in chemistry?

My interest in chemistry was inspired by a fundamental philosophical question: Is the material world a manifestation of the spiritual world? I hoped to find deep, sound answers from the solid laws of chemistry to answer this question, and to apply these answers to the external problems and open questions of the spiritual dimensions of life.

When you first discovered LSD did you have an intuitive sense that this drug would have the enormous impact on the world that it has?

I was convinced from the very beginning of the fundamental impact.

What motivated or inspired you to go back and synthesize LSD a second time in 1943?

I synthesized LSD a second time for a deeper pharmacological investigation.

How has your own use of LSD effected your philosophy of life?

LSD showed me the inseparable interaction between the material and the spiritual world.

What sort of association do you see between LSD and creativity?

Since LSD opens up what Aldous Huxley called “the Doors of Perception,” it enhances the fields of creative activity.

Do you think that LSD has effected human evolution?

I do not know if it has effected human evolution, but I hope so.

What are your thoughts on why LSD is almost universally prohibited by governments around the world?

LSD belongs to a class of psychoactive substances that provide the user with a new concept of life, and this new way of looking at life is op-posite to the officially accepted view.

What role do you see LSD playing in the future?

In the future, I hope that LSD provides to the individual a new world view which is in harmony with nature and its laws.

What do you think happens to consciousness after death?

I think that each individual’s consciousness becomes part of the universal mind.

What is your perspective on the concept of God and spirituality?

God is the name of the universal creative spirit.

What sort of relationship do you see between science and mysticism?

Science is objective knowledge and mysticism is personal spiritual experience.

Are you hopeful about the future, and how do you envision the future evolution of the human species?

I am hopeful about the future evolution of the human species, because I have the impression that more and more human individuals are becoming conscious – that the creative spirit, which we call “God,” speaks to us through his creation – through the endlessness of the starry sky, through the beauty and wonder of the living individuals of the plant, the animal, and the human kingdoms.

We human beings are able to understand this message because we possess the divine gift of consciousness. This connects us to the universal mind and gives us divine creativity. Any means that helps to expand our individual consciousness – by opening up and sharpening our inner and outer eyes, in order to understand the divine universal message – will help humanity to survive. An understanding of the divine message – in its universal language – would bring an end to the war between the religions of the world.

 
"So far in this book I have mainly described my scientific work and matters relating to my professional activity. But this work, by its very nature, had repercussions on my own life and personality, not least because it brought me into contact with interesting and important contemporaries. I have already mentioned some of them—Timothy Leary, Rudolf Gelpke, Gordon Wasson. Now, in the pages that follow, I would like to emerge from the natural scientist's reserve, in order to portray encounters which were personally meaningful to me and which helped me solve questions posed by the substances I had discovered."

A.H.


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Radiance from Ernst Jünger

Radiance is the perfect term to express the influence that Ernst Jünger's literary work and personality have had on me. In the light of his perspective, which stereoscopically comprises the surfaces and depths of things, the world I knew took on a new, translucent splendor. That happened a long time before the discovery of LSD and before I came into personal contact with this author in connection with hallucinogenic drugs.

My enchantment with Ernst Jünger began with his book Das Abenteuerliche Herz [The adventurous heart]. Again and again in the last forty years I have taken up this book. Here more than ever, in themes that weigh more lightly and lie closer to me than war and a new type of human being (subjects of Jünger's earlier books), the beauty and magic of Jünger's prose was opened to me-descriptions of flowers, of dreams, of solitary walks; thoughts about chance, the future, colors, and about other themes that have direct relation to our personal lives. Everywhere in his prose the miracle of creation became evident, in the precise description of the surfaces and, in translucence, of the depths; and the uniqueness and the imperishable in every human being was touched upon. No other writer has thus opened my eyes.

Drugs were also mentioned in Das Abenteuerliche Herz. Many years passed, however, before I myself began to be especially interested in this subject, after the discovery of the psychic effects of LSD.

My first correspondence with Ernst Jünger had nothing to do with the context of drugs; rather I once wrote to him on his birthday, as a thankful reader.

---

Bottmingen, 29 March 1947

Dear Mr. Jünger,

As one richly endowed by you for years, I wished to send a jar of honey to you for your birthday. But I did not have this pleasure, because my export license has been refused in Bern.

The gift was intended less as a greeting from a country in which milk and honey still flow, than as a reminiscence of the enchanting sentences in your book Auf den Marmorklippen (On the Marble Cliffs), where you speak of the "golden bees."

The book mentioned here had appeared in 1939, just shortly before the outbreak of World War II. Auf den Marmorklippen is not only a masterpiece of German prose, but also a work of great significance because in this book the characteristics of tyrants and the horror of war and nocturnal bombardment are described prophetically, in poetic vision.

In the course of our correspondence, Ernst Jünger also inquired about my LSD studies, of which he had learned through a friend. Thereupon I sent him the pertinent publications, which he acknowledged with the following comments:

Kirchhorst, 3/3/1948

. . . together with both enclosures concerning your new phantasticum. It seems indeed that you have entered a field that contains so many tempting mysteries.

Your consignment came together with the Confessions of an English Opium Eater, that has just been published in a new translation. The translator writes me that his reading of Das Abenteuerliche Herz stimulated him to do his work.

As far as I am concerned, my practical studies in this field are far behind me. These are experiments in which one sooner or later embarks on truly dangerous paths, and may be considered lucky to escape with only a black eye.

What interested me above all was the relationship of these substances to productivity. It has been my experience, however, that creative achievement requires an alert consciousness, and that it diminishes under the spell of drugs. On the other hand, conceptualization is important, and one gains insights under the influence of drugs that indeed are not possible otherwise. I consider the beautiful essay that Maupassant has written about ether to be such an insight. Moreover, I had the impression that in fever one also discovers new landscapes, new archipelagos, and a new music, that becomes completely distinct when the "customs station" ["An der Zollstation" [At the custom station], the title heading of a section in Das Abenteuerliche Herz (2d ed.) that concerns the transition from life to death.] appears. For geographic description, on the other hand, one must be fully conscious. What productivity means to the artist, healing means to the physician. Accordingly, it also may suffice for him that he sometimes enters the regions through the tapestries that our senses have woven. Moreover, I seem to perceive in our time less of a taste for the phantastica than for the energetica—amphetamine, which has even been furnished to fliers and other soldiers by the armies, belongs to this group. Tea is in my opinion a phantasticum, coffee an energeticum—tea therefore possesses a disproportionately higher artistic rank. I notice that coffee disrupts the delicate lattice of light and shadows, the fruitful doubts that emerge during the writing of a sentence. One exceeds his inhibitions. With tea, on the other hand, the thoughts climb genuinely upward.

So far as my "studies" are concerned, I had a manuscript on that topic, but have since burned it. My excursions terminated with hashish, that led to very pleasant, but also to manic states, to oriental tyranny....

Soon afterward, in a letter from Ernst Jünger I learned that he had inserted a discourse about drugs in the novel Heliopolis, on which he was then working. He wrote to me about the drug researcher who figures in the novel:

Among the trips in the geographical and metaphysical worlds, which I am attempting to describe there, are those of a purely sedentary man, who explores the archipelagos beyond the navigable seas, for which he uses drugs as a vehicle. I give extracts from his log book. Certainly, I cannot allow this Columbus of the inner globe to end well-he dies of a poisoning. Avis au lecteur.

The book that appeared the following year bore the subtitle Ruckblick auf eine Stadt [Retrospective on a city], a retrospective on a city of the future, in which technical apparatus and the weapons of the present time were developed still further in magic, and in which power struggles between a demonic technocracy and a conservative force took place. In the figure of Antonio Peri, Jünger depicted the mentioned drug researcher, who resided in the ancient city of Heliopolis.

He captured dreams, just like others appear to chase after butterflies with nets. He did not travel to the islands on Sundays and holidays and did not frequent the taverns on Pagos beach. He locked himself up in his studio for trips into the dreamy regions. He said that all countries and unknown islands were woven into the tapestry. The drugs served him as keys to entry into the chambers and caves of this world. In the course of the years he had gained great knowledge, and he kept a log book of his excursions. A small library adjoined this studio, consisting partly of herbals and medicinal reports, partly of works by poets and magicians. Antonio tended to read there while the effect of the drug itself developed. . . . He went on voyages of discovery in the universe of his brain....

In the center of this library, which was pillaged by mercenaries of the provincial governor during the arrest of Antonio Peri, stood The great inspirers of the nineteenth century: De Quincey, E.T.A. Hoffmann, Poe, and Baudelaire. Yet there were also books from the ancient past: herbals, necromancy texts, and demonology of the middle-aged world. They included the names Albertus Magnus, Raimundus Lullus, and Agrippa of Nettesheym.... Moreover, there was the great folio De Praestigiis Daemonum by Wierus, and the very unique compilations of Medicus Weckerus, published in Basel in 1582....

In another part of his collection, Antonio Peri seemed to have cast his attention principally "on ancient pharmacology books, formularies and pharmacopoeias, and to have hunted for reprints of journals and annals. Among others was found a heavy old volume by the Heidelberg psychologists on the extract of mescal buttons, and a paper on the phantastica of ergot by Hofmann-Bottmingen...."

In the same year in which Heliopolis came out, I made the personal acquaintance of the author. I went to meet Ernst Jünger in Ravensburg, for a Swiss sojourn. On a wonderful fall journey in southern Switzerland, together with mutual friends, I experienced the radiant power of his personality.

Two years later, at the beginning of February 1951, came the great adventure, an LSD trip with Ernst Jünger. Since, up until that moment, there were only reports of LSD experiments in connection with psychiatric inquiries, this experiment especially interested me, because this was an opportunity to observe the effects of LSD on the artistic person, in a nonmedical milieu. That was still somewhat before Aldous Huxley, from the same perspective, began to experiment with mescaline, about which he then reported in his two books The Doors of Perception and Heaven and Hell.

In order to have medical aid on hand if necessary, I invited my friend, the physician and pharmacologist Professor Heribert Konzett, to participate. The trip took place at 10:00 in the morning, in the living room of our house in Bottmingen. Since the reaction of such a highly sensitive man as Ernst Jünger was not foreseeable, a low dose was chosen for this first experiment as a precaution, only 0.05 mg. The experiment then, did not lead into great depths.

The beginning phase was characterized by the intensification of aesthetic experience. Red-violet roses were of unknown luminosity and radiated in portentous brightness. The concerto for flute and harp by Mozart was perceived in its celestial beauty as heavenly music. In mutual astonishment we contemplated the haze of smoke that ascended with the ease of thought from a Japanese incense stick. As the inebriation became deeper and the conversation ended, we came to fantastic reveries while we lay in our easy chairs with closed eyes. Ernst Jünger enjoyed the color display of oriental images: I was on a trip among Berber tribes in North Africa, saw colored caravans and lush oases. Heribert Konzett, whose features seemed to me to be transfigured, Buddha-like, experienced a breath of timelessness, liberation from the past and the future, blessedness through being completely here and now.

The return from the altered state of consciousness was associated with strong sensitivity to cold. Like freezing travelers, we enveloped ourselves in covers for the landing. The return to everyday reality was celebrated with a good dinner, in which Burgundy flowed copiously.

This trip was characterized by the mutuality and parallelism of our experiences, which were perceived as profoundly joyful. All three of us had drawn near the gate to an experience of mystical being; however, it did not open. The dose we had chosen was too low. In misunderstanding this reason, Ernst Jünger, who had earlier been thrust into deeper realms by a high dose of mescaline, remarked: "Compared with the tiger mescaline, your LSD, is, after all, only a house cat." After later experiments with higher doses of LSD, he revised this estimation.

Jünger has assimilated the mentioned spectacle of the incense stick into literature, in his story Besuch auf Gotenhotm [Visit to Godenholm], in which deeper experiences of drug inebriation also play a part: Schwarzenberg burned an incense stick, as he sometimes did, to clear the air. A blue plume ascended from the tip of the stick. Moltner looked at it first with astonishment, then with delight, as if a new power of the eyes had come to him. It revealed itself in the play of this fragrant smoke, which ascended from the slender stick and then branched out into a delicate crown. It was as if his imagination had created it-a pallid web of sea lilies in the depths, that scarcely trembled from the beat of the surf. Time was active in this creation-it had circled it, whirled about it, wreathed it, as if imaginary coins rapidly piled up one on top of another. The abundance of space revealed itself in the fiber work, the nerves, which stretched and unfolded in the height, in a vast number of filaments.

Now a breath of air affected the vision, and softly twisted it about the shaft like a dancer. Moltner uttered a shout of surprise. The beams and lattices of the wondrous flower wheeled around in new planes, in new fields. Myriads of molecules observed the harmony. Here the laws no longer acted under the veil of appearance; matter was so delicate and weightless that it clearly reflected them. How simple and cogent everything was. The numbers, masses and weights stood out from matter. They cast off the raiments. No goddess could inform the initiates more boldly and freely. The pyramids with their weight did not reach up to this revelation. That was Pythagorean luster. No spectacle had ever affected him with such a magic spell.

This deepened experience in the aesthetic sphere, as it is described here in the example of contemplation of a haze of blue smoke, is typical of the beginning phase of LSD inebriation, before deeper alterations of conscious begin.

I visited Ernst Jünger occasionally in the following years, in Wilfingen, Germany, where he had moved from Ravensburg; or we met in Switzerland, at my place in Bottmingen, or in Bundnerland in southeastern Switzerland. Through the shared LSD experience our relations had deepened. Drugs and problems connected with them constituted a major subject of our conversation and correspondence, without our having made further practical experiments in the meantime.

We exchanged literature about drugs. Ernst Jünger thus let me have for my drug library the rare, valuable monograph of Dr. Ernst Freiherrn von Bibra, Die Narkotischen Genussmittel und der Mensch [Narcotic pleasure drugs and man] printed in Nuremburg in 1855. This book is a pioneering, standard work of drug literature, a source of the first order, above all as relates to the history of drugs. What von Bibra embraces under the designation "Narkotischen Genussmittel" are not only substances like opium and thorn apple, but also coffee, tobacco, kat, which do not fall under the present conception of narcotics, any more than do drugs such as coca, fly agaric, and hashish, which he also described.

Noteworthy, and today still as topical as at the time, are the general opinions about drugs that von Bibra contrived more than a century ago: The individual who has taken too much hashish, and then runs frantically about in the streets and attacks everyone who confronts him, sinks into insignificance beside the numbers of those who after mealtime pass calm and happy hours with a moderate dose; and the number of those who are able to overcome the heaviest exertions through coca, yes, who were possibly rescued from death by starvation through coca, by far exceed the few coqueros who have undermined their health by immoderate use. In the same manner, only a misplaced hypocrisy can condemn the vinous cup of old father Noah, because individual drunkards do not know how to observe limit and moderation.

From time to time I advised Ernst Jünger about actual and entertaining events in the field of inebriating drugs, as in my letter of September 1955: . . . Last week the first 200 grams of a new drug arrived, whose investigation I wish to take up. It involves the seeds of a mimosa (Piptadenia peregrina Benth,) that is used as a stimulating intoxicant by the Indians of the Orinoco. The seeds are ground, fermented, and then mixed with the powder of burned snail shells. This powder is sniffed by the Indians with the help of a hollow, forked bird bone, as already reported by Alexander von Humboldt in Reise nach den Aequinoctiat-Gegenden des Neuen Kontinents [Voyage to the equinoctial regions of the new continent] (Book 8, Chapter 24). The warlike tribe, the Otomaco, especially use this drug, called niopo, yupa, nopo or cojoba, to an extensive degree, even today. It is reported in the monograph by P. J. Gumilla, S. J. (El Orinoco Ilustrado, 1741): "The Otomacos sniffed the powder before they went to battle with the Caribes, for in earlier times there existed savage wars between these tribes.... This drug robs them completely of reason, and they frantically seize their weapons. And if the women were not so adept at holding them back and binding them fast, they would daily cause horrible devastation. It is a terrible vice.... Other benign and docile tribes that also sniff the yupa, do not get into such a fury as the Otomacos, who through self-injury with this agent made themselves completely cruel before combat, and marched into battle with savage fury."

I am curious how niopo would act on people like us. Should a niopo session one day come to pass, then we should on no account send our wives away, as on that early spring reverie [The LSD trip of February 1951 is meant here.], that they may bind us fast if necessary....

Chemical analysis of this drug led to isolation of active principles that, like the ergot alkaloids and psilocybin, belong to the group of indole alkaloids, but which were already described in the technical literature, and were therefore not investigated further in the Sandoz laboratories. [Translator's note: The active principles of niopo are DMT (N,N-dimethyltryptamine) and its congeners. DMT was first prepared in 1931 by Manske.] The fantastic effects described above appeared to occur only with the particular manner of use as snuff powder, and also seemed to be related, in all probability, to the psychic structure of the Indian tribes concerned.

---

Ambivalence of Drug Use

Fundamental questions of drug problems were dealt with in the following correspondence. :

Bottmingen, 16 December 1961

Dear Mr. Jünger,

On the one hand, I would have the great desire, besides the natural-scientific, chemical-pharmacological investigation of hallucinogenic substances, also to research their use as magic drugs in other regions.... On the other hand, I must admit that the fundamental question very much occupies me, whether the use of these types of drugs, namely of substances that so deeply effect our minds, could not indeed represent a forbidden transgression of limits. As long as any means or methods are used, which provide only an additional, newer aspect of reality, surely there is nothing to object to in such means; on the contrary, the experience and the knowledge of further facets of the reality only makes this reality ever more real to us. The question exists, however, whether the deeply affecting drugs under discussion here will in fact only open an additional window for our senses and perceptions, or whether the spectator himself, the core of his being, undergoes alterations. The latter would signify that something is altered that in my opinion should always remain intact. My concern is addressed to the question, whether the innermost core of our being is actually unimpeachable, and cannot become damaged by whatever happens in its material, physical-chemical, biological and psychic shells-or whether matter in the form of these drugs displays a potency that has the ability to attack the spiritual center of the personality, the self. The latter would have to be explained by the fact that the effect of magic drugs happens at the borderline where mind and matter merge-that these magic substances are themselves cracks in the infinite realm of matter, in which the depth of matter, its relationship with the mind, becomes particularly obvious. This could be expressed by a modification of the familiar words of Goethe:

"Were the eye not sunny,
It could never behold the sun;
If the power of the mind were not in matter,
How could matter disturb the mind."

This would correspond to cracks which the radioactive substances constitute in the periodic system of the elements, where the transition of matter into energy becomes manifest. Indeed, one must ask whether the production of atomic energy likewise represents a transgression of forbidden limits.

A further disquieting thought, which follows from the possibility of influencing the highest intellectual functions by traces of a substance, concerns free will.

The highly active psychotropic substances like LSD and psilocybin possess in their chemical structure a very close relationship with substances inherent in the body, which are found in the central nervous system and play an important role in the regulation of its functions. It is therefore conceivable that through some disturbance in the metabolism of the normal neurotransmitters, a compound like LSD or psilocybin is formed, which can determine and alter the character of the individual, his world view and his behavior. A trace of a substance, whose production or nonproduction we cannot control with our wills, has the power to shape our destiny. Such biochemical considerations could have led to the sentence that Gottfried Benn quoted in his essay "Provoziertes Leben" [Provoked life]: "God is a substance, a drug!"

On the other hand, it is well known that substances like adrenaline, for example, are formed or set free in our organism by thoughts and emotions, which for their part determine the functions of the nervous system. One may therefore suppose that our material organism is susceptible to and shaped by our mind, in the same way that our intellectual essence is shaped by our biochemistry. Which came first can indeed no better be determined than the question, whether the chicken came before the egg.

In spite of my uncertainty with regard to the fundamental dangers that could lie in the use of hallucinogenic substances, I have continued investigations on the active principles of the Mexican magic morning glories, of which I wrote you briefly once before. In the seeds of this morning glory, that were called ololiuhqui by the ancient Aztecs, we found as active principles lysergic acid derivatives chemically very closely related to LSD. That was an almost unbelievable finding. I have all along had a particular love for the morning glories. They were the first flowers that I grew myself in my little child's garden. Their blue and red cups belong to the first memories of my childhood.

I recently read in a book by D. T. Suzuki, Zen and Japanese Culture, that the morning glory plays a great role in Japan, among the flower lovers, in literature, and in graphic arts. Its fleeting splendor has given the Japanese imagination rich stimulus. Among others, Suzuki quotes a three- line poem of the poetess Chiyo (1702-75), who one morning went to fetch water from a neighbor's house, because . . . "My trough is captivated by a morning glory blossom, So I ask after water."

The morning glory thus shows both possible ways of influencing the mind-body-essence of man: in Mexico it exerts its effects in a chemical way as a magic drug, while in Japan it acts from the spiritual side, through the beauty of its flower cups.

---

Wilflingen, 17 December 1961

Dear Mr. Hofmann,

I give you my thanks for your detailed letter of 16 December. I have reflected on your central question, and may probably become occupied with it on the occasion of the revision of An der Zeitmauer [At the wall of time]. There I intimated that, in the field of physics as well as in the field of biology, we are beginning to develop procedures that are no longer to be understood as advances in the established sense, but that rather intervene in evolution and lead forth in the development of the species. Certainly I turn the glove inside out, for I suppose that it is a new world age, which begins to act evolutionarily on the prototypes. Our science with its theories and discoveries is therefore not the cause, rather one of the consequences of evolution, among others. Animals, plants, the atmosphere and the surfaces of planets will be concerned simultaneously. We do not progress from point to point, rather we cross over a line.

The risk that you indicated is well to be considered. However, it exists in every aspect of our existence. The common denominator appears now here, now there.

In mentioning radioactivity, you use the word crack. Cracks are not merely points of discovery, but also points of destruction. Compared to the effects of radiation, those of the magical drugs are more genuine and much less rough. In classical manner they lead us beyond the humane. Gurdjieff has already seen that to some extent. Wine has already changed much, has brought new gods and a new humanity with it. But wine is to the new substances as classical physics is to modern physics. These things should only be tried in small circles. I cannot agree with the thoughts of Huxley, that possibilities for transcendence could here be given to the masses. Indeed, this does not involve comforting fictions, but rather realities, if we take the matter earnestly. And few contacts will suffice here for the setting of courses and guidance. It also transcends theology and belongs in the chapter of theogony, as it necessarily entails entry into a new house, in the astrological sense. At first, one can be satisfied with this insight, and should above all be cautious with the designations.

Heartfelt thanks also for the beautiful picture of the blue morning glory. It appears to be the same that I cultivate year after year in my garden. I did not know that it possesses specific powers; however, that is probably the case with every plant. We do not know the key to most. Besides this, there must be a central viewpoint from which not only the chemistry, the structure, the color, but rather all attributes become significant....

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An Experiment with Psilocybin

Such theoretical discussions about the magic drugs were supplemented by practical experiments. One such experiment, which served as a comparison between LSD and psilocybin, took place in the spring of 1962. The proper occasion for it presented itself at the home of the Jüngers, in the former head forester's house of Stauffenberg's Castle in Wilflingen. My friends, the pharmacologist Professor Heribert Konzett and the Islamic scholar Dr. Rudolf Gelpke, also took part in this mushroom symposium.

The old chronicles described how the Aztecs drank chocolatl before they ate teonanácatl. Thus Mrs. Liselotte Jünger likewise served us hot chocolate, to set the mood. Then she abandoned the four men to their fate.

We had gathered in a fashionable living room, with a dark wooden ceiling, white tile stove, period furniture, old French engravings on the walls, a gorgeous bouquet of tulips on the table. Ernst Jünger wore a long, broad, dark blue striped kaftan-like garment that he had brought from Egypt; Heribert Konzett was resplendent in a brightly embroidered mandarin gown; Rudolf Gelpke and I had put on housecoats. The everyday reality should be laid aside, along with everyday clothing.

Shortly before sundown we took the drug, not the mushrooms, but rather their active principle, 20 mg psilocybin each. That corresponded to some two-thirds of the very strong dose that was taken by the curandera Maria Sabina in the form of Psilocybe mushrooms.

After an hour I still noticed no effect, while my companions were already very deeply into the trip. I had come with the hope that in the mushroom inebriation I could manage to allow certain images from euphoric moments of my childhood, which remained in my memory as blissful experiences, to come alive: a meadow covered with chrysanthemums lightly stirred by the early summer wind; the rosebush in the evening light after a rain storm; the blue irises hanging over the vineyard wall. Instead of these bright images from my childhood home, strange scenery emerged, when the mushroom factor finally began to act. Half stupefied, I sank deeper, passed through totally deserted cities with a Mexican type of exotic, yet dead splendor. Terrified, I tried to detain myself on the surface, to concentrate alertly on the outer world, on the surroundings. For a time I succeeded. I then observed Ernst Jünger, colossal in the room, pacing back and forth, a powerful, mighty magician. Heribert Konzett in the silky lustrous housecoat seemed to be a dangerous, Chinese clown. Even Rudolf Gelpke appeared sinister to me; long, thin, mysterious.

With the increasing depth of inebriation, everything became yet stranger. I even felt strange to myself. Weird, cold, foolish, deserted, in a dull light, were the places I
traversed when I closed my eyes. Emptied of all meaning, the environment also seemed ghostlike to me whenever I opened my eyes and tried to cling to the outer world. The total emptiness threatened to drag me down into absolute nothingness. I remember how I seized Rudolf Gelpke's arm as he passed by my chair, and held myself to him, in order not to sink into dark nothingness. Fear of death seized me, and illimitable longing to return to the living creation, to the reality of the world of men. After timeless fear I slowly returned to the room . I saw and heard the great magician lecturing uninterruptedly with a clear, loud voice, about Schopenhauer, Kant, Hegel, and speaking about the old Gäa, the beloved little mother. Heribert Konzett and Rudolf Gelpke were already completely on the earth again, while I could only regain my footing with great effort.

For me this entry into the mushroom world had been a test, a confrontation with a dead world and with the void. The experiment had developed differently from what I had expected. Nevertheless, the encounter with the void can also be appraised as a gain. Then the existence of the creation appears so much more wondrous.

Midnight had passed, as we sat together at the table that the mistress of the house had set in the upper story. We celebrated the return with an exquisite repast and with Mozart's music. The conversation, during which we exchanged our experiences, lasted almost until morning.

Ernst Jünger has described how he had experienced this trip, in his book Annähenngen—Drogen und Rausch [Approaches-drugs and inebriation] (published by Ernst Klett Verlag, Stuttgart, 1970), in the section "Ein Pilz-Symposium" [A mushroom symposium]. The following is an extract from the work:

As usual, a half hour or a little more passed in silence. Then came the first signs: the flowers on the table began to flare up and sent out flashes. It was time for leaving work; outside the streets were being cleaned, like on every weekend. The brush strokes invaded the silence painfully. This shuffling and brushing, now and again also a scraping, pounding, rumbling, and hammering, has random causes and is also symptomatic, like one of the signs that announces an illness. Again and again it also plays a role in the history of magic practices.

By this time the mushroom began to act; the spring bouquet glowed darker. That was no natural light. The shadows stirred in the corners, as if they sought form. I became uneasy, even chilled, despite the heat that emanated from the tiles. I stretched myself on the sofa, drew the covers over my head.

Everything became skin and was touched, even the retina-there the contact was light. This light was multicolored; it arranged itself in strings, which gently swung back and forth; in strings of glass beads of oriental doorways. They formed doors, like those one passes through in a dream, curtains of lust and danger. The wind stirred them like a garment. They also fell down from the belts of dancers, opened and closed themselves with the swing of the hips, and from the beads a rippling of the most delicate sounds fluttered to the heightened senses. The chime of the silver rings on the ankles and wrists is already too loud. It smells of sweat, blood, tobacco, chopped horse hairs, cheap rose essence. Who knows what is going on in the stables?

It must be an immense palace, Mauritanian, not a good place. At this ballroom flights of adjoining rooms lead into the lower stratum. And everywhere the curtains with their glitter, their sparkling, radioactive glow. Moreover, the rippling of glassy instruments with their beckoning, their wooing solicitation: "Will you go with me, beautiful boy?" Now it ceased, now it repeated, more importunate, more intrusive, almost already assured of agreement.

Now came forms-historical collages, the vox humana, the call of the cuckoo. Was it the whore of Santa Lucia, who stuck her breasts out of the window? Then the play was ruined. Salome danced; the amber necklace emitted sparks and made the nipples erect. What would one not do for one's Johannes? [Translator's note: "Johannes" here is slang for penis, as in English "Dick" or "Peter."] -damned, that was a disgusting obscenity, which did not come from me, but was whispered through the curtain.

The snakes were dirty, scarcely alive, they wallowed sluggishly over the floor mats. They were garnished with brilliant shards. Others looked up from the floor with red and green eyes. It glistened and whispered, hissed and sparkled like diminutive sickles at the sacred harvest. Then it quieted, and came anew, more faintly, more forward. They had me in their hand. "There we immediately understood ourselves."

Madam came through the curtain: she was busy, passed by me without noticing me. I saw the boots with the red heels. Garters constricted the thick thighs in the middle, the flesh bulged out there. The enormous breasts, the dark delta of the Amazon, parrots, piranhas, semiprecious stones everywhere.

Now she went into the kitchen-or are there still cellars here? The sparkling and whispering, the hissing and twinkling could no longer be differentiated; it seemed to become concentrated, now proudly rejoicing, full of hope.

It became hot and intolerable; I threw the covers off. The room was faintly illuminated; the pharmacologist stood at the window in the white mandarin frock, which had served me shortly before in Rottweil at the carnival. The orientalist sat beside the tile stove; he moaned as if he had a nightmare. I understood; it had been a first round, and it would soon start again. The time was not yet up. I had already seen the beloved little mother under other circumstances. But even excrement is earth, belongs like gold to transformed matter. One must come to terms with it, without getting too close.

These were the earthy mushrooms. More light was hidden in the dark grain that burst from the ear, more yet in the green juice of the succulents on the glowing slopes of Mexico. . . . [Translator's note: Jünger is referring to LSD, a derivative of ergot, and mescaline, derived from the Mexican peyotl cactus.]

The trip had run awry—possibly I should address the mushrooms once more. Yet indeed the whispering returned, the flashing and sparkling—the bait pulled the fish close behind itself. Once the motif is given, then it engraves itself, like on a roller each new beginning, each new revolution repeats the melody. The game did not get beyond this kind of dreariness.

I don't know how often this was repeated, and prefer not to dwell upon it. Also, there are things which one would rather keep to oneself. In any case, midnight was past....

We went upstairs; the table was set. The senses were still heightened and the Doors of Perception were opened. The light undulated from the red wine in the carafe; a froth surged at the brim. We listened to a flute concerto. It had not turned out better for the others: How beautiful, to be back among men." Thus Albert Hofmann.

The orientalist on the other hand had been in Samarkand, where Timur rests in a coffin of nephrite. He had followed the victorious march through cities, whose dowry on entry was a cauldron filled with eyes. There he had long stood before one of the skull pyramids that terrible Timur had erected, and in the multitude of severed heads had perceived even his own. It was encrusted with stones. A light dawned on the pharmacologist when he heard this: Now I know why you were
sitting in the armchair without your head-I was astonished; I knew I wasn't dreaming.

I wonder whether I should not strike out this detail since it borders on the area of ghost stories.

The mushroom substance had carried all four of us off, not into luminous heights, rather into deeper regions. It seems that the psilocybin inebriation is more darkly colored in the majority of cases than the inebriation produced by LSD. The influence of these two active substances is sure to differ from one individual to another. Personally, for me, there was more light in the LSD experiments than in the experiments with the earthy mushroom, just as Ernst Jünger remarks in the preceding report.

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Another LSD Session

The next and last thrust into the inner universe together with Ernst Jünger, this time again using LSD, led us very far from everyday consciousness. We came close to the ultimate door. Of course this door, according to Ernst Jünger, will in fact only open for us in the great transition from life into the hereafter.

This last joint experiment occurred in February 1970, again at the head forester's house in Wilflingen. In this case there were only the two of us. Ernst Jünger took 0.15 mg LSD, I took 0.10 mg. Ernst Jünger has published without commentary the log book, the notes he made during the experiment, in Approaches, in the section "Nochmals LSD" [LSD once again]. They are scanty and tell the reader little, just like my own records.

The experiment lasted from morning just after breakfast until darkness fell. At the beginning of the trip, we again listened to the concerto for flute and harp by Mozart, which always made me especially happy, but this time, strange to say, seemed to me like the turning of porcelain figures. Then the intoxication led quickly into wordless depths. When I wanted to describe the perplexing alterations of consciousness to Ernst Jünger, no more than two or three words came out, for they sounded so false, so unable to express the experience; they seemed to originate from an infinitely distant world that had become strange; I abandoned the attempt, laughing hopelessly. Obviously, Ernst Jünger had the same experience, yet we did not need speech; a glance sufficed for the deepest understanding. I could, however, put some scraps of sentences on paper, such as at the beginning: "Our boat tosses violently." Later, upon regarding expensively bound books in the library: "Like red-gold pushed from within to without-exuding golden luster." Outside it began to snow. Masked children marched past and carts with carnival revelers passed by in the streets. With a glance through the window into the garden, in which snow patches lay, many-colored masks appeared over the high walls bordering it, embedded in an infinitely joyful shade of blue: "A Breughel garden—I live with and in the objects." Later: "At present—no connection with the everyday world." Toward the end, deep, comforting insight expressed: "Hitherto confirmed on my path." This time LSD had led to a blessed approach.

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90



Meeting with Aldous Huxley

In the mid-1950s, two books by Aldous Huxley appeared, The Doors of Perception and Heaven and Hell, dealing with inebriated states produced by hallucinogenic drugs. The alterations of sensory perceptions and consciousness, which the author experienced in a self-experiment with mescaline, are skillfully described in these books. The mescaline experiment was a visionary experience for Huxley. He saw objects in a new light; they disclosed their inherent, deep, timeless existence, which remains hidden from everyday sight.

These two books contained fundamental observations on the essence of visionary experience and about the significance of this manner of comprehending the world—in cultural history, in the creation of myths, in the origin of religions, and in the creative process out of which works of art arise. Huxley saw the value of hallucinogenic drugs in that they give people who lack the gift of spontaneous visionary perception belonging to mystics, saints, and great artists, the potential to experience this extraordinary state of consciousness, and thereby to attain insight into the spiritual world of these great creators. Hallucinogens could lead to a deepened understanding of religious and mystical content, and to a new and fresh experience of the great works of art. For Huxley these drugs were keys capable of opening new doors of perception; chemical keys, in addition to other proven but laborious " door openers" to the visionary world like meditation, isolation, and fasting, or like certain yoga practices.

At the time I already knew the earlier work of this great writer and thinker, books that meant much to me, like Point Counter Point, Brave New World, After Many a Summer, Eyeless in Gaza, and a few others. In The Doors of Perception and Heaven and Hell, Huxley's newly-published works, I found a meaningful exposition of the experience induced by hallucinogenic drugs, and I thereby gained a deepened insight into my own LSD experiments.

I was therefore delighted when I received a telephone call from Aldous Huxley in the laboratory one morning in August 1961. He was passing through Zurich with his wife. He invited me and my wife to lunch in the Hotel Sonnenberg.

A gentleman with a yellow freesia in his buttonhole, a tall and noble appearance, who exuded kindness—this is the image I retained from this first meeting with Aldous Huxley. The table conversation revolved mainly around the problem of magic drugs. Both Huxley and his wife, Laura Archera Huxley, had also experimented with LSD and psilocybin. Huxley would have preferred not to designate these two substances and mescaline as "drugs," because in English usage, as also by the way with Droge in German, that word has a pejorative connotation, and because it was important to differentiate the hallucinogens from the other drugs, even linguistically. He believed in the great importance of agents producing visionary experience in the modern phase of human evolution.

He considered experiments under laboratory conditions to be insignificant, since in the extraordinarily intensified susceptibility and sensitivity to external impressions, the surroundings are of decisive importance. He recommended to my wife, when we spoke of her native place in the mountains, that she take LSD in an alpine meadow and then look into the blue cup of a gentian flower, to behold the wonder of creation.

As we parted, Aldous Huxley gave me, as a remembrance of this meeting, a tape recording of his lecture "Visionary Experience," which he had delivered the week before at an international congress on applied psychology in Copenhagen. In this lecture, Aldous Huxley spoke about the meaning and essence of visionary experience and compared this type of world view to the verbal and intellectual comprehension of reality as its essential complement.

In the following year, the newest and last book by Aldous Huxley appeared, the novel Island. This story, set on the utopian island Pala, is an attempt to blend the achievements of natural science and technical civilization with the wisdom of Eastern thought, to achieve a new culture in which rationalism and mysticism are fruitfully united. The moksha medicine, a magical drug prepared from a mushroom, plays a significant role in the life of the population of Pala (moksha is Sanskrit for "release," "liberation"). The drug could be used only in critical periods of life. The young men on Pala received it in initiation rites, it is dispensed to the protagonist of the novel during a life crisis, in the scope of a psychotherapeutic dialogue with a spiritual friend, and it helps the dying to relinquish the mortal body, in the transition to another existence.

In our conversation in Zurich, I had already learned from Aldous Huxley that he would again treat the problem of psychedelic drugs in his forthcoming novel. Now he sent me a copy of Island, inscribed "To Dr. Albert Hofmann, the original discoverer of the moksha medicine, from Aldous Huxley."

The hopes that Aldous Huxley placed in psychedelic drugs as a means of evoking visionary experience, and the uses of these substances in everyday life, are subjects of a letter of 29 February 1962, in which he wrote me: . . . I have good hopes that this and similar work will result in the development of a real Natural History of visionary experience, in all its variations, determined by differences of physique, temperament and profession, and at the same time of a technique of Applied Mysticism—a technique for helping individuals to get the most out of their transcendental experience and to make use of the insights from the "Other World" in the affairs of "This World." Meister Eckhart wrote that "what is taken in by contemplation must be given out in love." Essentially this is what must be developed—the art of giving out in love and intelligence what is taken in from vision and the experience of self-transcendence and solidarity with the Universe....

Aldous Huxley and I were together often at the annual convention of the World Academy of Arts and Sciences (WAAS) in Stockholm during late summer 1963. His suggestions and contributions to discussions at the sessions of the academy, through their form and importance, had a great influence on the proceedings.

WAAS had been established in order to allow the most competent specialists to consider world problems in a forum free of ideological and religious restrictions and from an international viewpoint encompassing the whole world. The results: proposals, and thoughts in the form of appropriate publications, were to be placed at the disposal of the responsible governments and executive organizations.

The 1963 meeting of WAAS had dealt with the population explosion and the raw material reserves and food resources of the earth. The corresponding studies and proposals were collected in Volume II of WAAS under the title The Population Crisis and the Use of World Resources. A decade before birth control, environmental protection, and the energy crisis became catchwords, these world problems were examined there from the most serious point of view, and proposals for their solution were made to governments and responsible organizations. The catastrophic events since that time in the aforementioned fields makes evident the tragic discrepancy between recognition, desire, and feasibility.

Aldous Huxley made the proposal, as a continuation and complement of the theme "World Resources" at the Stockholm convention, to address the problem "Human Resources," the exploration and application of capabilities hidden in humans yet unused. A human race with more highly developed spiritual capacities, with expanded consciousness of the depth and the incomprehensible wonder of being, would also have greater understanding of and better consideration for the biological and material foundations of life on this earth. Above all, for Western people with their hypertrophied rationality, the development and expansion of a direct, emotional experience of reality, unobstructed by words and concepts, would be of evolutionary significance. Huxley considered psychedelic drugs to be one means to achieve education in this direction. The psychiatrist Dr. Humphry Osmond, likewise participating in the congress, who had created the term psychedelic (mind-expanding), assisted him with a report about significant possibilities of the use of hallucinogens.

The convention in Stockholm in 1963 was my last meeting with Aldous Huxley. His physical appearance was already marked by a severe illness; his intellectual personage, however, still bore the undiminished signs of a comprehensive knowledge of the heights and depths of the inner and outer world of man, which he had displayed with so much genius, love, goodness, and humor in his literary work.

Aldous Huxley died on 22 November of the same year, on the same day President Kennedy was assassinated. From Laura Huxley I obtained a copy of her letter to Julian and Juliette Huxley, in which she reported to her brother- and sister-in-law about her husband's last day. The doctors had prepared her for a dramatic end, because the terminal phase of cancer of the throat, from which Aldous Huxley suffered, is usually accompanied by convulsions and choking fits. He died serenely and peacefully, however.

In the morning, when he was already so weak that he could no longer speak, he had written on a sheet of paper: "LSD—try it—intramuscular—100 mmg." Mrs. Huxley understood what was meant by this, and ignoring the misgivings of the attending physician, she gave him, with her own hand, the desired injection-she let him have the moksha medicine.

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Walter.Vogt_.DeutscheFotothek.png



Correspondence with the Poet-Physician Walter Vogt

My friendship with the physician, psychiatrist, and writer Walter Vogt, M.D., is also among the personal contacts that I owe to LSD. As the following extract from our correspondence shows, it was less the medicinal aspects of LSD, important to the physician, than the consciousness-altering effects on the depth of the psyche, of interest to the writer, that constituted the theme of our correspondence.

Muri/Bern, 22 November 1970

Dear Mr. Hofmann,

Last night I dreamed that I was invited to tea in a cafe by a friendly family in Rome. This family also knew the pope, and so the pope sat at—the same table to tea with us. He was all in white and also wore a white miter. He sat there so handsome and was silent.

And today I suddenly had the idea of sending you my Vogel auf dem Tisch [Bird on the table—as a visiting card if you so wish—a book that remained a little apocryphal, which upon reflection I do not regret, although the Italian translator is firmly convinced that is my best. (Ah yes, the pope is also an Italian. So it goes. ...)

Possibly this little work will interest you. It was written in 1966 by an author who at that time still had not had any shred of experience with psychedelic substances and who read the reports about medicinal experiments with these drugs devoid of understanding. However, little has changed since, except that now the misgiving comes from the other side.

I suppose that your discovery has caused a hiatus (not directly a Saul-to-Paul conversion as Roland Fischer says...) in my work (also a large word) - and indeed, that which I have written since has become rather realistic or at least less expressive. In any case I could not have brought off the cool realism of my TV piece "Spiele der Macht" [Games of power] without it. The different drafts attest it, in case they are still lying around somewhere.

Should you have interest and time for a meeting, it would delight me very much to visit you sometime for a conversation.

W. V.

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Burg, i.L. 28 November 1970

Dear Mr. Vogt,

If the bird that alighted on my table was able to find its way to me, this is one more debt I owe to the magical effect of LSD. I could soon write a book about all of the results that derive from that experiment in 1943....

A. H.

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Muri/Bern, 13 March 1971

Dear Mr. Hofmann,

Enclosed is a critique of Jünger's Annahenngen [Approaches], from the daily paper, that will presumably interest you....

It seems to me that to hallucinate—to dream—to write, stands at all times in contrast to everyday consciousness, and their functions are complementary. Here I can naturally speak only for myself. This could be different with others—it is also truly difficult to speak with others about such things, because people often speak altogether different languages....

However, since you are now gathering autographs, and do me the honor of incorporating some of my letters in your collection, I enclose for you the manuscript of my "testament"—in which your discovery plays a role as "the only joyous invention of the twentieth century...."

W. V. dr. walter vogts most recent testament 1969

I wish to have no special funeral
only expensive and obscene orchids
innumerable little birds with gay names
no naked dancers
but
psychedelic garments
loudspeaker in every corner and
nothing but the latest beatles record [Abbey Road]
one hundred thousand million times
and
do what you like ["Blind Faith"]
on an endless tape
nothing more
than a popular Christ with a halo of genuine gold
and a beloved mourning congregation
that pumped themselves full with LSD
till they go to heaven [From Abbey Road, side two]
one two three four five six seven
possibly we will encounter one another there

most cordially dedicated
to Dr. Albert Hofmann
Beginning of Spring 1971

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urg i.L., 29 March 1971

Dear Mr. Vogt,

You have again presented me with a lovely letter and a very valuable autograph, the testament 1969....

Very remarkable dreams in recent times induce me to test a connection between the composition (chemical) of the evening meal and the quality of dreams. Yes, LSD is also something that one eats....

A. H.

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Muri/Bern, 5 September 1971

Dear Mr. Hofmann,

Over the weekend at Murtensee [On that Sunday, I (A. H.) hovered over the Murtensee in the balloon of my friend E. I., who had taken me along as passenger.] I often thought of you—a most radiant autumn day. Yesterday, Saturday, thanks to one tablet of aspirin (on account of a headache or mild flu), I experienced a very comical flashback, like with mescaline (of which I have had only a little, exactly once)....

I have read a delightful essay by Wasson about mushrooms; he divides mankind into mycophobes and mycophiles.... Lovely fly agarics must now be growing in the forest near you. Sometime shouldn't we sample some?

W. V.

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Muri/Bern, 7 September 1971

Dear Mr. Hofmann,

Now I feel I must write briefly to tell you what I have done outside in the sun, on the dock under your balloon: I finally wrote some notes about our visit in Villars-sur-Ollons (with Dr. Leary), then a hippie-bark went by on the lake, self-made like from a Fellini film, which I sketched, and over and above it I drew your balloon.

W. V.

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Burg i.L., 15 April 1972

Dear Mr. Vogt,

Your television play "Spiele der Macht" [Games of power] has impressed me extraordinarily.

I congratulate you on this magnificent piece, which allows mental cruelty to become conscious, and therefore also acts in its way as "consciousness- expanding", and can thereby prove itself therapeutic in a higher sense, like ancient tragedy.

A. H.

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Burg i.L., 19 May 1973

Dear Mr. Vogt,

Now I have already read your lay sermon three times, the description and interpretation of your Sinai Trip. [Walter Vogt: Mein Sinai Trip. Eine Laienpredigt [My Sinai trip: A lay sermon] (Verlag der Arche, Zurich, 1972). This publication contains the text of a lay sermon that Walter Vogt gave on 14 November 1971 on the invitation of Parson Christoph Mohl, in the Protestant church of Vaduz (Lichtenstein), in the course of a series of sermons by writers, and in addition contains an afterword by the author and by the inviting parson. It involves the description and interpretation of an ecstatic-religious experience evoked by LSD, that the author is able to "place in a distant, if you will superficial, analogy to the great Sinai Trip of Moses." It is not only the "patriarchal atmosphere" that is to be traced out of these descriptions, that constitutes this analogy; there are deeper references, which are more to be read between the lines of this text.] Was it really an LSD trip?... It was a courageous deed, to choose such a notorious event as a drug experience as the theme of a sermon, even a lay sermon. But the questions raised by hallucinogenic drugs do actually belong in the church—in a prominent place in the church, for they are sacred drugs (peyotl, teonanacatl, ololiuhqui, with which LSD is mostly closely related by chemical structure and activity).

I can fully agree with what you say in your introduction about the modern ecclesiastical religiosity: the three sanctioned states of consciousness (the waking condition of uninterrupted work and performance of duty, alcoholic intoxication, and sleep), the distinction between two phases of psychedelic inebriation (the first phase, the peak of the trip, in which the cosmic relationship is experienced, or the submersion into one's own body, in which everything that is, is within; and the second phase, characterized as the phase of enhanced comprehension of symbols), and the allusion to the candor that hallucinogens bring about in consciousness states. These are all observations that are of fundamental importance in the judgment of hallucinogenic inebriation.

The most worthwhile spiritual benefit from LSD experiments was the experience of the inextricable intertwining of the physical and spiritual. "Christ in matter" (Teilhard de Chardin). Did the insight first come to you also through your drug experiences, that we must descend "into the flesh, which we are," in order to get new prophesies?

A criticism of your sermon: you allow the "deepest experience that there is"—"The kingdom of heaven is within you"—to be uttered by Timothy Leary. This sentence, quoted without the indication of its true source, could be interpreted as ignorance of one, or rather the principal truth of Christian belief.

One of your statements deserves universal recognition: "There is no non-ecstatic religious experience."...

Next Monday evening I shall be interviewed on Swiss television (about LSD and the Mexican magic drugs, on the program "At First Hand"). I am curious about the sort of questions that will be asked...

A. H.

---

Muri/Bern, 24 May 1973

Dear Mr. Hofmann,

Of course it was LSD—only I did not want to write about it explicitly, I really do not know just why myself.... The great emphasis I placed on the good Leary, who now seems to me to be somewhat flipped out, as the prime witness, can indeed only be explained by the special context of the talk or sermon.

I must admit that the perception that we must descend "into the flesh, which we are" actually first came to me with LSD. I still ruminate on it, possibly it even came "too late" for me in fact, although more and more I advocate your opinion that LSD should be taboo for youth (taboo, not forbidden, that is the difference...).

The sentence that you like, "there is no nonecstatic religious experience," was apparently not liked so much by others—for example, by my (almost only) literary friend and minister-lyric poet Kurt Marti.... But in any case, we are practically never of the same opinion about anything, and notwithstanding, we constitute when we occasionally communicate by phone and arrange little activities together, the smallest minimafia of Switzerland.

W. V.

---

Burg i.L., 13 April 1974

Dear Mr. Vogt,

Full of suspense, we watched your TV play "Pilate before the Silent Christ" yesterday evening.

... as a representation of the fundamental man-God relationship: man, who comes to God with his most difficult questions, which finally he must answer himself, because God is silent. He does not answer them with words. The answers are contained in the book of his creation (to which the questioning man himself belongs). True natural science deciphering of this text.

A. H.

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Muri/Bern, 11 May 1974

Dear Mr. Hofmann,

I have composed a "poem" in half twilight, that I dare to send to you. At first I wanted to send it to Leary, but this would make no sense.

Leary in jail
Gelpke is dead
Treatment in the asylum
is this your psychedelic
revolution?
Had we taken seriously something
with which one only ought to play
or
vice-versa...

W. V.

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The Road to Eleusis: An Interview with Albert Hofmann​


Enchant | FAENA aleph

Albert Hofmann is interviewed by eminent thinkers in a Spanish T.V. show in 1989.​


Following the celebration of the honoris causa at the University of Bilbao given to the illustrious Ernst Junger, a group of thinkers had the opportunity to interview Albert Hoffman, who at the time was considered one of the hundred greatest living geniuses alive.

Since his doctoral thesis, Hofmann had showed signs of an exceptional talent for his discovery of the chemical structure of chitin, the material that claws, shells and the wings of some insects are made of. Later, the scientist gained great reputation by discovering new painkillers and tranquilizers for the pharmacology department of Sandoz laboratories, which he joined in 1929.

It was precisely there that Hofmann discovered the substance his name would forever be linked to: LSD. As a fruit of his study on the properties of ergot, a fungus prone to parasitizing wheat, Hofmann synthetized lysergic acid diethylamide, an experimental substance that would be left out of his study until five years later when a hunch led the Swiss chemist to experiment with it once again.

In the aforementioned interview, Hofmann centers on the relation of this substance with the Eleusinian Mysteries of Ancient Greece, a theme divulged in his book The Road to Eleusis, written in collaboration with Robert Gordon Wasson and Carl A.P Ruck. Hofmann’s thesis claims that, together with different initiation rituals, an enlightening potion that must have been very similar to the composition of LSD was also administered at the time.

The Eleusinian Mysteries, esoteric religious rituals parallel and complementary to the state religion, were devoted to the Greek goddess Demeter ––the deity associated with the cycles of grain and agriculture. In these Mysteries, which prevailed in Greece for over a thousand years, a series of individuals were initiated in the secret knowledge of creation.

Among the reasons that led Hofmann to this hypothesis is that in the vicinity of Eleusis there grows, in the midst of the wildest grass, a peculiar kind of ergot. Eleusinian priests would just have to pick it, grind it and make the initiated ingest it to provoke an enlightening experience.

The fact that the Mysteries were devoted to the goddess Demeter, the goddess of agriculture and fertility, is, according to Hofmann, more proof of the relationship between the substance and the mystic ritual.

To Hofmann, the most important thing was to prove that the ingestion of these substances was always linked to the sacred, and that their use had to be subjected to the demands of the ritual and the observance of a high priest. By abolishing the habitual division between the self and the other, between the subject and his surroundings, and facilitating the access to a non-dualist reality, the experience with psychedelic substances, in his view, was almost identical to the enlightening experience of religions. But he also warned that, without the correct treatment, without the correct preparation that was granted in mystic environments, the experience with these substances could be fatal ––they can prompt several types of psychic trauma.

Today, in absence of a religion like that of Eleusis, only psychiatrists would be qualified to replace the priest on the path to an enlightening experience.

Hofmann departs with his fellows, proving his profound knowledge and his humanist wisdom. He tells us of his experience and describes his relationship with another myth of his time: Aldous Huxley.

When asked if at his age he continues to experiment with LSD, Hofmann answers he does not.
What it could have given me, it has given me already. Now I limit myself to living in accordance with those teachings.

Evidently, for Albert Hofmann, the doors of perception were already wide open.

 
Albert-Hofmann-1976.jpg



Interview with Albert Hofmann

The late chemist Albert Hofmann discussed his psychedelic research on LSD in the July, 1976 issue of High Times.

Swiss scientist Albert Hofmann was born January 11, 1906 and died April 29, 2008. In an exclusive interview published in the July, 1976 edition of High Times, Hofmann looked back at his illustrious career.



At the height of World War II, four months after the first artificially created nuclear reaction was released in a pile of uranium ore in Chicago, an accidentally absorbed trace of a seminatural rye fungus product quietly exploded in the brain of a 37-year-old Swiss chemist working at the Sandoz research laboratories in Basel. He reported to his supervisor: “I was forced to stop my work in the laboratory in the middle of the afternoon and to go home, as I was seized by a peculiar restlessness associated with a sensation of mild dizziness … a kind of drunkenness which was not unpleasant and which was characterized by extreme activity of imagination … there surged upon me an uninterrupted stream of fantastic images of extraordinary plasticity and vividness and accompanied by an intense, kaleidoscopelike play of colors….”

Three days later, on April 19, 1943, Dr. Albert Hofmann undertook a self-experiment that both confirmed the results of his earlier psychoactive experience and revealed a fascinating new discovery: Here was the first known substance that produced psychic effects from dosages so tiny they were measurable only in micrograms! Dr. Hofmann had discovered LSD-25.

Lysergic acid diethylamide (LSD) was enthusiastically investigated by the European psychiatric profession as a possible key to the chemical nature of mental illness. Its effects were believed to mimic the psychotic state. As soon as LSD was introduced to American psychiatry in 1950, interest spread rapidly among the United States military and domestic security interests. By the middle 1950s, LSD was being researched as a creativity enhancer and learning stimulant; rumors of its ecstatic, mystic and psychic qualities began to leak out through the writings of Aldous Huxley, Robert Graves and other literary luminaries.

A large-scale, non-medical experiment involving LSD and other psychedelic drugs at Harvard in the early Sixties precipitated a fierce controversy over the limits of academic freedom and focused national attention on the drug now known as “acid.” Midway through the turbulent decade, one million people had tried black-market LSD, engendering a neurological revolution the fallout of which has not yet been assessed. In 1966, Congress outlawed LSD.

Dr. Hofmann now lives in comfortable retirement on a hill overlooking the Swiss-French border. He granted High Times this exclusive interview to discuss not only the implications of his discovery of LSD, but also his less publicized chemical investigations into the active agents of several sacred Mexican plants.

Considering his life’s work, Dr. Hofmann seems a likely candidate for the Nobel Prize in chemistry. Not only have his discoveries broadened our knowledge of psychoactive chemicals and triggered the imaginations of thousands of scientists, historians and other researchers, but they have had a direct and revolutionary impact on humanity’s ability to understand and help itself.



Preliminary Note

I was at first not in agreement with the idea of publishing this interview here. I was surprised and shocked at the existence of such a magazine, whose text and advertising tended to treat the subject of illegal drugs with a casual and non-responsible attitude. Also, the manner in which High Times treats marijuana policy, which urgently needs a solution, does not correspond to my approach. Nevertheless, I came to the decision that my statement’s appearing in a magazine directed to readers who use currently illegal drugs might be of special value and could help to diminish the abuse or misuse of the psychedelic drugs. Michael Horowitz convinced me that an accurate description of the discovery of LSD and the Mexican magic plants, about which so many misleading versions exist, and my opinion on the various aspects of the drug problem, among other topics, would be useful to a large audience of interested persons in the United States. The aims of this interview are to provide information about what these kinds of drugs can and cannot do, and what their potential dangers are.

—Albert Hoffman, March 24, 1976




High Times: What work did you do prior to your discovery of LSD?

Hofmann: In the early years of my career in the pharmaceutical research laboratory of Sandoz in Basel, I was occupied mainly with investigations on the cardiac components, the glycosides, of squill, or Scilla maritima. These investigations resulted in the elucidation of the chemical constitution of the common nucleus of these agents, which provide valuable medicaments that are often used in the treatment of cardiac failure.

From 19351 worked on the alkaloids of ergot, resulting in the development of ergonovine, the first synthetic preparation of natural ergot alkaloids; Methergine, used in obstetrics to stop hemorrhage; Hydergine for geriatric complaints.

In 1943 the results of this first period of my research in the ergot field were published in a professional journal, Helvetica Chimica Acta. As a result of my first eight years of ergot research, I synthesized a large number of ergot derivatives: amides of lysergic acid, lysergic acid being the characteristic nucleus of natural ergot alkaloids. Among these amides of lysergic acid there was also the diethylamide of lysergic acid.

High Times: Did you have LSD in your laboratory as early as 1938?

Hofmann: Yes. At that time a number of pharmacological experiments were carried out in Sandoz’s department of pharmacology. Marked excitation was observed in some of the animals. But these effects did not seem interesting enough to my colleagues in the department.

Work on LSD fell into abeyance for a number of years. As I had a strange feeling that it would be valuable to carry out more profound studies with this compound, I prepared a fresh quantity of LSD in the spring of 1943. In the course of this work, an accidental observation led me to carry out a planned self-experiment with this compound, which then resulted in the discovery of the extraordinary psychic effects of LSD.

High Times: What sort of drug were you trying to make when you synthesized LSD?

Hofmann: When I synthesized lysergic acid diethylamide, laboratory code name LSD-25 or simply LSD, I had planned the preparation of an analeptic compound, which means a circulatory and respiratory stimulant. Lysergic acid diethylamide is related in chemical structure to nicotinic acid diethylamide, known to be an effective analeptic.

High Times: Was the discovery of LSD an accident?

Hofmann: I would say that LSD was the outcome of a complex process that had its beginning in a definite concept and was followed by an appropriate synthesis—that is, the synthesis of lysergic acid diethylamide—during the course of which a chance observation served to trigger a planned self-experiment, which then led to the discovery of the psychic effects of this compound.

High Times: Does “LSD-25” mean that the preparation of LSD with the characteristic psychoactive effects was the twenty-fifth one you made?

Hofmann: No, the number 25 behind LSD means that lysergic acid diethylamide was the twenty-fifth compound I had prepared in the series of lysergic acid amides.

High Times: In the published report of your first LSD experience on April 16, 1943, at 3:00 P.M. in Basel, you write of a “laboratory intoxication.” Did you swallow something or breathe a vapor, or did some drops of solution fall upon you ?

Hofmann: No, I did not swallow anything, and I was used to working under very clean conditions, because these substances in general are toxic. You have to work very, very cleanly. Probably a trace of the solution of lysergic acid diethylamide I was crystallizing from methyl alcohol was absorbed through the skin of my fingers.

High Times: How big a dose did you take that first time, and what were the nature and intensity of that experience?

Hofmann: I don’t know—an immeasurable trace. The first experience was a very weak one, consisting of rather small changes. It had a pleasant, fairy tale-magic theater quality. Three days later, on April 19, 1943, I made my first planned experiment with 0.25 milligrams, or 250 micrograms.

High Times: Did you swallow it?

Hofmann: Yes, I prepared a solution of 5 milligrams and took a fraction corresponding to 250 micrograms, or 25 millionths of a gram. I didn’t expect this dose to work at all, and planned to take more and more to get the effects. There was no other substance known at the time which had any effect with so small a dose.

High Times: Did your colleagues know that you were making this experiment?

Hofmann: Only my assistant.

High Times: Were you familiar with the work done on mescaline by Klüver, Beringer and Rouhier in the late 1920s before you yourself experimented with mind-altering substances?

Hofmann: No—I became interested in their work only after the discovery of LSD. They are pioneers in the field of psychoactive plants.

Mescaline, studied for the first time by Lewin in 1888, was the first hallucinogen available as a chemically pure compound; LSD was the second. Karl Beringer’s investigations were published in the classic monograph Der Meskalinrausch in 1928, but in the years following, interest in the hallucinogenic research faded.

Not until my discovery of LSD, which is about 5,000 to 10,000 times more active than mescaline, did this line of research receive a new impetus.

High Times: How long were you able to keep writing lab notes that afternoon?

Hofmann: Not very. As the effects intensified I realized that I did not know what was going to happen, if I’d ever come back. I thought I was dying or going crazy. I thought of my wife and two young children who would never know or understand why I could have done this. My first planned self-experiment with LSD was a “bum trip,” as one would say nowadays.

High Times: Why was it four years from your discovery of the psychic effects of LSD until your report was published? Was your information suppressed?

Hofmann: There was no suppression of that knowledge. After confirmation of the action of this extraordinary compound by volunteers of the Sandoz staff, Professor Arthur Stoll, who was then head of the Sandoz pharmaceutical department, asked me if I would permit his son, Werner A. Stoll—who was starting his career at the psychiatric hospital of the University of Zurich—to submit this new agent to a fundamental psychiatric study on normal volunteers and on psychiatric patients. This investigation took a rather long time, because Dr. Stoll, like myself and most young Swiss people in that period of war, often had to interrupt his work to serve in the army. This excellent and comprehensive study was not published until 1947.

High Times: Did government agents aware of LSD approach you during World War ll?

Hofmann: Before Werner Stoll’s psychiatric report appeared in 1947, there was no general knowledge of LSD. In military circles in the 1950s, however, there was open discussion of LSD as an “incapacitating drug,” and thus “a weapon without death.” At that time the U.S. Army sent a representative to Sandoz to speak to me about the procedure for producing large quantities of LSD.

Of course, the plan to use it as an “incapacitating agent” was not practicable because there was no way of uniformly distributing doses—some would get a lot and some would get none. Discussions of the military uses of LSD were no secret at that time, although some journalists speak as if they were.

High Times: Arthur Stoll’s name appears with yours on the chemical paper where the synthesis of LSD is first described. What was his connection with this investigation?

Hofmann: Stoll’s name appears on all papers coming out of the research laboratories at Sandoz as part of his function of head of the department, but he had no direct connection with the discovery of LSD. He was one of the pioneers in ergot research, having isolated in 1918 the first chemically pure alkaloid from ergot—ergotamine—which proved to be a useful medicament in the treatment of migraine. But then research on ergot was discontinued at Sandoz until I started it again in 1935.

High Times: Who was the second person to take LSD?

Hofmann: Professor Ernst Rothlin, head of the Sandoz pharmacological department at the time. Rothlin was dubious about LSD; he claimed he had a strong will and could suppress the effects of drugs. But after he took 60 micrograms—one quarter of the dose I had taken earlier—he was convinced. I had to laugh as he described his fantastic visions.

High Times: Have you taken LSD outside of the laboratory?

Hofmann: Around 1949 to 1951, I arranged some LSD sessions at home in the friendly and private company of two good friends of mine: the pharmacologist Professor Heribert-Konzett, and the writer Ernst Jünger. Jünger is the author of, among other works, Approaching Revelation: Drugs and Narcotics [Annäherungen; Drogen und Rausch. Stuttgart: Klett, 1970].

I did this in order to investigate the influence of the surroundings, of the outer and inner conditions on the LSD experience. These experiments showed me the enormous impact of—to use modern terms—set and setting on the content and character of the experience.

I also learned that planning has its limitations. In spite of good mood at the beginning of a session—positive expectations, beautiful surroundings and sympathetic company—I once fell into a terrible depression. This unpredictability of effects is the major danger of LSD.

High Times: How long and how often did you continue to take LSD?

Hofmann: My ten to 15 experiments with LSD were distributed over 27 years. The last one was in 1970. Since then I have taken no more LSD, because I believe that all an LSD experience can give me has already been given. Maybe later in my life I will have the need to take it once or several times more.

High Times: What was the largest single dose of LSD that you took ?

Hofmann: 250 micrograms.

High Times: Would you recommend the use of LSD?

Hofmann: I suppose that your question refers to the non-medical use of LSD. If such use were at present legal, which is not the case, then I would suggest the following guidelines: The experience is handled best by a ripe, stabilized person with a meaningful reason for taking LSD.

With regard to its psychic effects and its chemical constitution, LSD belongs to that group of Mexican drugs, peyotl, teonanacatl and ololiuqui, that became sacred drugs because of their uncanny way of affecting the core of the mind. The Indians’ religious awe of the psychedelic drug may be replaced in our society by respect and reverence, based on scientifically established knowledge of its unique psychic effects.

This respectful attitude toward LSD must be supplemented by appropriate external conditions—by choosing an inspiring milieu and selected company for the session, and having medical assistance available just in case it is needed.

High Times: Are the effects of ergotism similar to those of LSD?

Hofmann: There are two forms of ergotism: ergotismus gangrenosus and ergotismus convulsivus. The former is characterized by symptoms of gangrene, but without accompanying psychic effects. In the latter form, contractions and convulsions of the muscles often culminate in a state comparable to epilepsy—a condition sometimes accompanied by hallucinations, and thus related to the effects of LSD. This can be explained by the fact that the alkaloids of ergot have the same basic nucleus as LSD; that is, they are derivatives of lysergic acid.

High Times: Is the term psychedelic, coined by Dr. Humphry Osmond, agreeable to you?

Hofmann: I think it is a good term. It corresponds better to the effects of these drugs than hallucinogenic or psychotomimetic. Another suitable designation would have been phantastica, coined by Louis Lewin in the 1920s, but it was not accepted in English-speaking countries.

High Times: You have described your psychoactive drug investigations as a “magic circle.” What do you mean?

Hofmann: My investigations of lysergic acid amides brought me to LSD. LSD brought the sacred Mexican mushrooms to my attention, which led to the synthesis of psilocybin, which in turn brought about a visit from Gordon Wasson and the subsequent investigations with ololiuqui. There I again encountered lysergic acid amides, closing the magic circle 17 years later.

High Times: Can you describe the events leading up to that?

Hofmann: After having studied the mushroom ceremony in Mexico during 1954 and 1955, Gordon Wasson and his wife invited the mycologist Roger Heim to accompany them on a further expedition in 1956 in order to identify the sacred mushroom.

He discovered that most of them were a new species belonging to the genus Psilocybe mexicana of the family of Strophariaceae. He was able to cultivate some of them artificially in his Paris laboratory, but after unsuccessful attempts to isolated the active principle, he sent the sacred mushrooms to the Sandoz laboratory in hopes that our experience with LSD would enable us to solve this problem. In a sense, LSD brought the sacred mushrooms to my laboratory.

We first tested the mushroom extract on animals, but the results were negative. It was uncertain whether the mushrooms cultivated and dried in Paris were still active at all, so in order to settle this fundamental point I decided to test them on myself. I ate 32 dried specimens of Psilocybe mexicana.

High Times: Isn’t that a large dose?

Hofmann: No. The mushrooms were very tiny, weighing only 2.4 grams—a medium dose by Indian standards.

High Times: What was it like?

Hofmann: Everything assumed a Mexican character. Whether my eyes were closed or open, I saw only Mexican motifs and colors. When the doctor supervising the experiment bent over to check my blood pressure, he was transformed into an Aztec priest, and I would not have been astonished had he drawn an obsidian knife.

It was a strong experience and lasted about six hours. The mushrooms were active; the negative results of the test with animals had been due to the comparatively low sensitivity of animals to substances with psychic effects.

High Times: Did you then proceed with the synthesis?

Hofmann: After this reliable test with human beings, meaning that my coworkers and I ingested the fractions to be tested, I extracted the active principles from the mushrooms, purified and finally crystallized them.

I named the main active principle of Psilocybe mexicana psilocybin and the accompanying alkaloid, usually present only in small amounts, psilocin. My co-workers and I were then able to elucidate the chemical structure of psilocybin and psilocin, and after that we succeeded in synthesizing these compounds.

The synthetic production of psilocybin is now much more economic than obtaining it from the mushroom. Thus teonanacatl was demystified —the two substances whose magic effects made the Mexican Indians believe for thousands of years that a god resided in a mushroom can now be prepared in a retort.

High Times: In one of his recorded lectures, Aldous Huxley described the delight of Wasson’s famous curandera, Maria Sabina of Huautla, upon ingesting psilocybin. She realized that she could now perform magic all year round, and not just during the mushroom season following the rains.

Hofmann: That was my psilocybin. When Wasson and I visited Maria Sabina there were no sacred mushrooms because it was so late in the season, so we provided her with pills containing synthetic psilocybin.

After taking a rather strong dose in the course of a nocturnal session, she said there was no difference between the pills and the mushrooms. “The spirit of the mushroom is in the pill,” she said—final proof that our synthetic preparation was identical in every respect with the natural product.

High Times: What prompted your investigations of ololiuqui, another of the Mexican sacred plants?

Hofmann: When Wasson came to Sandoz to view the synthetic psilocybin crystals in my laboratory, he was delighted that the results of our chemical investigation had confirmed his ethnomycological studies of the sacred mushroom. We became friends and made plans to further investigate Mexican sacred plants.

The next problem we decided to tackle was the riddle of ololiuqui, which is the Aztec name for the seeds of certain morning-glories. With Wasson’s help, I was able to obtain ololiuqui seeds collected by Zapotec Indians.

The chemical analysis of the ololiuqui seeds gave a quite surprising result. The active principle that we isolated proved to be lysergic acid amide and other ergot alkaloids.

High Times: So ololiuqui is chemically related to LSD ?

Hofmann: Yes. The main ololiuqui alkaloid is lysergic acid amide, which differs from LSD —from lysergic acid diethylamide—only by two ethyl radicals. I did not expect to find lysergic acid derivatives—which were known until then only as products of lower fungi of the ergot type—also in higher plants, in morning-glory species of the phanerogamic family of the Convolvulaceae.

My results were so surprising that the first paper I delivered on the subject in Melbourne in 1960 was received by my colleagues with skepticism. They would not believe me. “Oh, you have so much lysergic acid compounds in your laboratory, you may have contaminated your ololiuqui extracts with them,” they said.

High Times: What was the purpose of your journey to Mexico?

Hofmann: It was an expedition that Wasson organized in the autumn of 1962 to search for another, unidentified magic Mexican plant, namely the so-called hojas de la Pastora. We traveled by horseback on Indian trails through the Sierra Mazateca, finally arriving in time to assist in a nocturnal ceremony in the hut of a curandera who used the juice of the leaves of hojas de la Pastora.

Afterwards we were able to get some specimens of the plant. It was a new species of the mint family that was later identified botanically at Harvard University and named Salvia divinorum. Back in my laboratory at Sandoz, I had no success in extracting the active principle, which in Salvia divinorum is very unstable.

High Times: Are the psychoactive effects of Salvia divinorum similar to those of Psilocyhe mexicana and LSD?

Hofmann: Yes, but less pronounced.

High Times: What writers do you find to be the most successful in conveying the psychedelic experience in literature?

Hofmann: I find the best descriptions in Aldous Huxley’s books. After that I would say Timothy Leary and Alan Watts; in France, Henri Michaux.

In German literature. Rudolf Gelpke deserves to be named in this respect, but I don’t believe his works are available in English. “Von Fahrten in den Weltraum der Seele” [“Travels in the Cosmos of the Soul”], published in the journal Antaios in 1962, is especially fine.

I should also mention the new monograph by Dr. Stan Grof, Realms of the Human Unconscious [New York: Viking, 1975], containing excellent descriptions of LSD sessions in the framework of psychiatric studies.

High Times: Did Herman Hesse or Carl Jung ever show an interest in your discovery?

Hofmann: I never met Hesse, but his books—especially The Glass Bead Game and Steppenwolf— have deeply interested me in connection with LSD research. It is possible that Hesse experimented with mescaline in the 1920s as some have supposed —I have no way of knowing. Outside of one brief meeting with Jung at an international congress of psychiatrists, I had no contact with him.

High Times: Did you ever meet Aldous Huxley?

Hofmann: Twice. I met him for lunch in Zurich in 1961, and again in 1963 when we were both in Stockholm attending the WAAS [World Academy of Art and Science] Conference, where the topics of overpopulation, depletion of natural resources and ecology in general were discussed. I was deeply impressed by Huxley: he radiated life, intelligence, kindness and openness —and he was of course extremely articulate.

High Times: What do you think of The Tibetan Book of the Dead as a guide to the psychedelic experience, as suggested by Huxley and the Harvard researchers, among others?

Hofmann: The general ideas and instructions on how to prepare and run a psychedelic session given there are the outcome of long experiences in this field and seem very valuable. What disturbs me is the use of the foreign Tibetan symbolism. I prefer that we remain within our own cultural framework—that we use symbols found in the writings of Western mystics such as Silesius, Eckhart, Boehme and Swedenborg.

High Times: What was your impression of Dr. Timothy Leary’s work with psychedelics?

Hofmann: I formed my first impression of Dr. Leary in 1963. At that time he was involved, together with his colleague Dr. Richard Alpert, at Harvard University in a project investigating the use of LSD and psilocybin in the rehabilitation of convicts. Dr. Leary sent me an order for 100 grams of LSD and 25 kilograms of psilocybin. Before the sales department of Sandoz could carry out the demand for this extraordinarily large quantity of psychedelic compounds we asked Dr. Leary to provide us with the necessary import license from the U.S. health authorities. He failed to provide it. The unrealistic manner with which he handled this transaction left the impression of a person unconcerned with the regulations of society.

I got a glimpse of another facet of his character when he invited me later the same year to participate in a meeting on drug research at Zihuatanejo, Mexico. He emphasized that radio, television and journalists of the most important mass media would be present, which revealed a very publicity-conscious personality.

High Times: You met with Leary later, didn’t you?

Hofmann: A decade later when Dr. Leary had escaped from prison and was living in exile in Switzerland. I was eager to meet him personally, having read so much in the press about him during the intervening period. On the third of September, 1971, the father and prophet of LSD met in Lausanne.

I was surprised to meet not a professorial type of scientist, nor a fanatic, but a slender, smiling, boyish man, representing rather a tennis champion than a Harvard professor.

During the course of our conversation. Dr. Leary gave me the impression of an idealistic person who believes in the transforming influence of psychedelic drugs on mankind, is conscious of the complexity of the drug problem and yet was careless of all the difficulties involved in the promotion of his ideas.

High Times: Apart from his personal style, what did you think of Dr. Leary’s ideas at the time of the Swiss meeting?

Hofmann: We were in agreement concerning the enormous importance of making a fundamental distinction between drugs. We agreed that the use of addiction-producing drugs, especially heroin with its disastrous somatic and psychic effects, should be avoided by any means possible. We agreed also in the evaluation of the potentially beneficial effects of psychedelic drugs. We disagreed as to the extent that psychedelics should be used and by whom.

Whereas Dr. Leary advocated the use of LSD under appropriate conditions by very young people, by teenagers, I insisted that a ripe, stable personality be a prior condition. Ripe because the drug can release only what is already in the mind. It brings in nothing new—it is like a key that can open a door to our subconscious. Stabilized because it needs spiritual strength for handling and integrating an overwhelming psychedelic experience into the existing Weltbild.

High Times: Does LSD possess aphrodisiac qualities?

Hofmann: Only in the sense that LSD adds new dimensions to all experiences, including of course the sexual.

High Times: Have you benefitted financially from your discovery of LSD?

Hofmann: No.

High Times: Sandoz is one of the largest pharmaceutical firms in the world. How did it deal with the manufacture and distribution of so controversial a substance as LSD?

Hofmann: It was clear from the very beginning that LSD, in spite of its extraordinary qualities, would not become a pharmaceutical preparation of commercial value. Notwithstanding this, Sandoz put enormous effort into the scientific investigation of the substance, showing the eminent role LSD could play as an excellent tool in brain research and in psychiatry.

Sandoz therefore made LSD available to qualified experimental and clinical investigators all over the world to promote such research with technical help and in many instances with financial support. Sandoz played a noble role in the scientific development of LSD.

High Times: Did Sandoz stop producing LSD because it was finding its way onto the black market?

Hofmann: At the onset of the LSD hysteria in 1965, Sandoz completely stopped the distribution of LSD for research purposes in order to avoid all possibility and to counteract false rumors that its LSD could find its way onto the black market.

Another reason was to force health authorities of different countries to provide adequate rules and regulations regarding the distribution of LSD. After this was accomplished, they again supplied LSD in America to the FDA [Food and Drug Administration] for distribution, but only to licensed investigators.

High Times: In the United States there has been a recent major investigation of improper LSD experiments carried out by the CIA, Army, Navy and other governmental agencies. Did they get their LSD from Sandoz just as Timothy Leary’s psychedelic research project at Harvard got theirs?

Hofmann: Sandoz supplied the U.S. Food and Drug Administration, who then distributed it in America. Probably that is how the CIA and others got it.

High Times: Have you ever been approached by Soviet agents in need of Sandoz LSD or of your expertise?

Hofmann: This has not happened. I have learned from Swedish scientists in Stockholm that the Russians have studied LSD’s uses in military and parapsychological investigations, and that they were searching for an antidote. But the pharmaceutical firm of Spofa in Prague probably provided the LSD.

High Times: Are you familiar with the underground chemist, Stanley Owsley, who in the 1960s produced the most widely distributed black-market LSD?

Hofmann: I have heard his name mentioned in this context, but know nothing else about him.

High Times: What has been the purity of the black-market LSD that you’ve tested?

Hofmann: Some contained the “labeled” amount, some less. It’s difficult to make a stable preparation under less than perfect laboratory conditions. You must eliminate every trace of oxygen. Oxidation destroys LSD, as does light.

High Times: Are you familiar with an LSD-like substance called ALD-52 that figured prominently in an acid trial two years ago?

Hofmann: Yes. ALD-52 is Acetyl-LSD, a modification of LSD that proved to be as active, because acetyl is removed in the body and you have the effects of LSD. It has only been used experimentally. We sent it to the Drug Rehabilitation Center in Lexington, Kentucky, for testing some years ago.

High Times: What do you know about ketamine?

Hofmann: Ketamine is a totally synthetic psychedelic, unlike LSD, which is a seminatural product.

High Times: What is now known about the neurological effects of LSD and other psychedelics?

Hofmann: We know LSD concentrates in the hypothalamus, the same region of the brain where serotonin is found. This is the brain’s emotional center. But there still exists a big gap between the pharmacology of and the mechanisms underlying consciousness.

The problem is that the thought-function that you investigate is the same instrument you use for investigation.

High Times: For many people LSD provides what they describe as a religious experience. What are your feelings on this?

Hofmann: People for whom LSD provides a religious experience expect to have such an experience when they take it. Expectation —which is identical to autosuggestion—determines to a high degree what will happen in the session, because one of the most important features of the LSD state is its extreme suggestibility.

Another reason for the incidence of religious experiences is the fact that the very core of the human mind is connected with God. This deepest root of our consciousness, which in the normal state is hidden by superficial rational activities of the mind, may become revealed by the action of the psychedelic drug.

High Times: Is LSD an evolutionary agent?

Hofmann: Possibly. In the LSD state we may become conscious, in the words of Teilhard de Chardin, of the “entire complex of interhuman and intercosmic relations with an immediacy, an intimacy and a realism” that otherwise happens only in spontaneous ecstatic states and to a very few blessed people.

Agreement exists among spiritual leaders that the continuation of the present development, characterized by increasing industrialization and overpopulation, will result in the exhaustion of natural resources and destroy the ecological basis for mankind’s existence on this planet. This trend to self-annihilation is reinforced by international politics based on “power trips” and the preparation of weapons of apocalyptic potential.

This development can be stopped only by a change in the materialistic attitude that has caused this development. This change can result only from insight into the deepest spiritual roots of life and existence, from comprehensive use of all forces of our intelligence and all resources of our knowledge.

This intellectual approach, supplemented by visionary experience, could produce an alteration of the consciousness of truth and reality that could be of evolutionary significance. LSD selectively and wisely used could be one means of supplementing intellectual with visionary insight and helping the prepared mind become conscious of a deeper reality.

High Times: Did your LSD experiences change your personal life and tastes?

Hofmann: It increased my sensitivity to classical music—especially Mozart. My life habits did not change.

High Times: Has your wife also experimented with psychedelics?

Hofmann: Yes. Once in Mexico in the session with Salvia divinorum when I had some gastric trouble and could not ingest the juice, she took my place. She also took some of the psilocybin pills during the historic session when Maria Sabina confirmed their potency.

High Times: What general medical uses might LSD be marketed for in the future?

Hofmann: Very small doses, perhaps 25 micrograms, could be useful as a euphoriant or antidepressant.

High Times: Which of your works are available in English?

Hofmann: Several years ago Dr. Richard Evans Schultes of Harvard and I coauthored a book called The Botany and Chemistry of Hallucinogens. It is intended primarily to provide specialized students with basic knowledge of the botany and chemistry of hallucinogenic plants. I am currently writing my memoirs, but these will first be published in German.

High Times: What have you been doing since your retirement from Sandoz?

Hofmann: I retired in 1971 after 42 years with Sandoz. Since then I have been writing and lecturing on psychoactive drugs. Here at home I work in the orchard and run in the woods for exercise. It’s wonderful to be able to spend a great deal of time in unspoiled nature after decades of work in laboratories.

High Times: In his book Gravity’s Rainbow, the American author Thomas Pynchon has described a stained-glass window in your office at the otherwise dull Sandoz labs. Is this true?

Hofmann: That is true. It is now here in my house. Actually, it’s a modern glass in the old style depicting Asclepius and his mentor, the centaur Chiron.

High Times: Are the Swiss proud of your discovery of LSD and the synthesis of psilocybin and ololiuqui, or has the controversy surrounding these drugs dispelled that?

Hofmann: My discoveries have proved very controversial. Some consider these drugs to be diabolique, and a few clergymen asked me to confess mea culpa in public, but in professional circles my work has been appreciated. I’ve been honored by the National Polytechnic Institute here in Switzerland; by honorary degrees in natural science and in pharmacy from the Swedish Royal Pharmaceutical Institute, and in the United States by an honorary membership in the American Society of Pharmacognosy.

High Times: What made you decide to become a chemist?

Hofmann: I was interested in knowing what our world is made of. Chemistry is the science of the constituents of the world, so at age 19 I made the decision to become a chemist for both mystical-philosophical reasons and for reasons of curiosity.

High Times: Has LSD affected your philosophical outlook?

Hofmann: From my LSD experiments, including the very first terrifying one, I have received knowledge of not only one. but of an infinite number of realities. Depending upon the condition of our senses and psychic receptors we experience a different reality.

I realized that the depth and richness of the inner and outer universe are immeasurable and inexhaustible, but that we have to return from these strange worlds to our homeland and live here in the reality that is provided by our normal, healthy senses. It’s like astronauts returning from outer space flights: they must readjust to this planet.

In some of my psychedelic experiences I had a feeling of ecstatic love and unity with all creatures in the universe. To have had such an experience of absolute beatitude means an enrichment of our life.

High Times: How would you like the future ages to remember you and your discovery?

Hofmann: Perhaps the image of a chemist riding along on a bicycle on the very first LSD trip will change to the Old Man of the Mountain.

 
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A Conversation with Albert Hofmann

On November 26, 1996, Charles Grob, M.D. visited with Albert Hofmann in Rheinfelden, outside of Basel, Switzerland, where Dr. Hofmann was recovering from knee surgery. Following are excerpts from their conversation.

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CG: Dr. Hofmann, thank you for speaking with me. I would like to tape record our discussion, with the understanding that you will be provided a transcript for review and approval before publication. I would first like to ask how old are you currently, and how is your health?

AH: I am 90 years old, and I am feeling very fit. I had knee surgery last month, but am now doing very well. The rehabilitation hospital has provided excellent physical therapies for my knee, and I am almost ready to go home to Rittematte. I am in very good condition, and swim in the indoor pool every day. I will miss the swimming, but I am looking forward to going home soon.

CG: I would like to speak with you about your views on psychedelic drugs. To start with, do you believe it is possible to re- establish psychedelic research as a respectable scientific field?

AH: I think there are many good signs. After years of silence, there have recently been some investigations in Switzerland and Germany, and also in the United States. We had a meeting in Heidelberg last year (European College for the Study of Consciousness), and there were many good presentations. In Heidelberg I enjoyed meeting with Rick Doblin (of MAPS) and Professor Nichols (of the Heffter Research Institute), and I think both of their organizations are doing fine work. Their approach appears to be quite different than that of some of their predecessors from several decades ago.

CG: Are you referring to Dr. Leary?

AH: Yes. I was visited by Timothy Leary when he was living in Switzerland many years ago. He was a very intelligent man, and quite charming. I enjoyed our conversations very much. However, he also had a need for too much attention. He enjoyed being provocative, and that shifted the focus from what should have been the essential issue. It is unfortunate, but for many years these drugs became taboo. Hopefully, these same problems from the Sixties will not be repeated.

CG: From the vantage point of where we are now, in the late 1990s, what implications do psychedelic drugs have to the field of psychiatry?

AH: I believe that shortly after LSD was discovered, it was recognized as being of great value to psychoanalysis and psychiatry. It was not considered to be an escape. It was a very important discovery at that time, and for fifteen years it could be used legally in psychiatric treatment and for scientific study in humans. During this time, Delysid, the name I gave to LSD, was used safely, and was the subject of thousands of publications in the professional literature. Actually, just last week, I had visitors from the Albert Hofmann Foundation, to whom I gave all of the original documentation, which had been stored at the Sandoz Laboratories. This early work was very well documented, and shows how well research with LSD went until it became part of the drug scene in the 1960s. So, from originally being part of the therapeutic pharmacopeia, LSD became a drug of the street and inevitably it was made illegal. Because of this reputation, it became unavailable to the medical field, and so the research, which had been very open, was stopped. Now it appears that this research may start again. The importance of such investigations appears to be recognized by the health authorities, and so it is my hope that finally the prohibition is coming to an end, and the medical field can return to the explorations which were forced to stop thirty years ago.

CG: What recommendations would you give to researchers now who want to work with these substances?

AH: When LSD was distributed legally by Sandoz, there was a little brochure which was given together with the Delysid, which explained how LSD could be used. As an aid to psychoanalysis and psychotherapy, and also as a means for psychiatrists themselves to experience these extraordinary states of mind. It was specifically stated on the package insert that the psychiatrist who was interested in using Delysid should first test it on himself.

CG: So, you would say that it is very important that the researcher, the psychiatrist, know first hand the psychedelic experience?

AH: Absolutely, absolutely. Before it can be used in clinical work, it must most definitely be taken by the psychiatrist. From the very first reports and guidelines written for LSD, this was clearly stated. And this remains of utmost importance today.

CG: Are there lessons we can learn from the past insofar as what went wrong with the research, why it was stopped, that we should be attentive to, so mistakes are not repeated?

AH: Yes, if it would be possible to stop their improper use, their misuse, then I think it would be possible to dispense them for medical use. But as long as they continue to be misused, and as long as people fail to truly understand psychedelics and continue to use them as pleasure drugs and fail to appreciate the very deep, deep, psychic experiences they may induce, then their medical use will be held back. Their use on the streets has been a problem for more than thirty years. On the streets the drugs are misunderstood, and accidents occur. This makes it very difficult for the health authorities to change their policies and allow medical use. And although it should be possible to convince the health authorities that in responsible hands psychedelics could be used safely in the medical field, their use on the streets continues to make it very hard for the health authorities to agree.

CG: It appears that young people are once again becoming interested in psychedelics and MDMA. We also have this new phenomenon of the rave, where young people take substances like MDMA and dance all night. What is your view on why these young people seek out such experiences? How can we respond to what they are doing?

AH: This is a very, very deep problem of our time in that we no longer have a religious basis in our lives. Even with religion, with the churches, they are no longer convincing with their dogma. And people need a deep spiritual foundation for their lives. In older times it was religion, with their dogmas, which people believed in, but today those dogmas no longer work. We cannot believe things which we know are not possible, that are not real. We must go on the basis of what we know, that everybody can experience. On this basis, you must find the entrance to the spiritual world. Because many young people are looking for meaningful experiences, they are looking for this thing which is the opposite of the material world. Not all young people are looking for money and power. Some are looking for a happiness and satisfaction which is of the spiritual world, not the materialistic world. They are looking, but there are no sanctioned paths. And, of course, one of the ways young people are using is with psychedelic drugs.

CG: What would you say to young people?

AH: What I would say would most certainly be: Open your eyes! The doors of perception must be opened. That means these young people must learn by their own experience, to see the world as it was before human beings were on this planet. That is the real problem today, that people live in towns and cities, where everything is dead. This material world, made by humans, is a dead world, and will disappear and die. I would tell the young people to go out into the countryside, go to the meadow, go to the garden, go to the woods. This is a world of nature to which we belong, absolutely. It is the circle of life, of which we are an integral part. Open your eyes, and see the browns and greens of the earth, and the light which is the essence of nature. The young need to become aware of this circle of life, and realize that it is possible to experience the beauty and deep meaning which is at the core of our relation to nature.

CG: When did you first acquire this visionary appreciation of nature?

AH: When I was a young boy, I had many opportunities to walk through the countryside. I had profound and visionary encounters with nature, and this was long before I conducted my initial experiments with LSD. Indeed, my first experiences with LSD were very reminiscent of these early mystical encounters I had had as a child in nature. So, you see that it is even possible to have these experiences without drugs. But many people are blocked, without an inborn faculty to realize beauty, and it is these people who may need a psychedelic in order to have a visionary experience of nature.

CG: How do we reconcile this visionary experience with religion and with scientific truth?

AH: It is important to have the experience directly. Aldous Huxley taught us not to simply believe the words, but to have the experience ourselves. This is why the different forms of religion are no longer adequate. They are simply words, words, words, without the direct experience of what it is the words represent. We are now at a phase of human development where we have accumulated an enormous amount of knowledge through scientific research in the material world. This is very important knowledge, but it must be integrated. What science has brought to light is true, absolutely true. But this is only one part, only one side of our existence, that of the material world. We have a body, and matter gets older and changes, so therefore as far as our having a body, we must die. But the spiritual world, of course, is eternal, but only insofar as it exists in the moment. It is important that we realize this enormous difference between these two sides of our lives. The material world is the world of our body, but the material world is also where man has made all of these scientific and technological discoveries. We must see, then, that science and technology are based on natural laws. But we must also accept that the material world is only the manifestation of the spiritual world. And if we attempt to manifest something, we will have to make use of the material world. For you and I to speak with one another, we must have tongues, we must have air and so forth. All of this is of the material world. If we were to read about spiritual things, it is only words. We must have the experience directly. And the experience occurs only by opening the mind, and opening all of our senses. Those doors of perception must be cleansed. And if the experience does not come spontaneously, on its own, then we may make use of what Huxley calls a gratuitous grace. This may take the form of psychedelic drugs, or perhaps without drugs through a discipline like yoga. But what is of greatest importance, is that we have personal experience. Not words, not beliefs, but experience.

CG: Projecting into the future, do you envision that there may be an accepted role within Euro-American culture for psychedelics?

AH: Absolutely! I am convinced that the importance of psychedelics will be recognized. The pathway for this is through psychiatry, but not the psychoanalytic psychiatry of Freud and not the limited scope of modern biological psychiatry. Rather, it will occur through the new field of transpersonal psychiatry. This transpersonal view takes into account both the material world, including our body, as well as the spiritual world. It recognizes that we are simultaneously part of the material and the spiritual worlds. What fits with the concept of transpersonal psychiatry is that we open our doors of perception. What transpersonal psychiatry tries to give us is a recipe for gaining entrance into the spiritual world. This fits exactly with the results of psychedelics. It stimulates your senses. It opens your perception for your own experience. How this phenomenon affects our existence in the material world can be understood through scientific research, and how we can integrate this knowledge with our spiritual selves can be achieved through the transpersonal path.

CG: Dr. Hofmann, you have lived through two World Wars and a Cold War. When you look ahead into the future of mankind, are you hopeful or not?

AH: I am hopeful for the long distant future, but for the near future I am terribly, terribly pessimistic. I believe that what is occurring in the material world is a reflection of the spiritual state of mankind. I fear that many terrible things will occur around the world, because mankind is in spiritual crisis. But I hope that over time mankind will learn, finally learn, and that there will be hope. I just re-read the twelve lectures Aldous Huxley gave in San Francisco in 1959, called The Human Situation. I think that everything that we are concerned about today, about the ego, consciousness, the survival of mankind, it can all be read in this book. I would like to recommend it. Everything we are now trying to say, the ideas we are formulating, has been discussed by Huxley.

CG: What can we learn from the so-called primitive cultures who used psychedelic substances as part of their religious practices?

AH: I think the most important thing is that they use it in a religious framework and we don't. We must learn from them, we must identify the right structures, we must find new uses. I could imagine that it may be possible to create meditation centers for psychedelic use in natural surroundings, where teachers could have experiences and train to become adepts. I perceive this as being possible, but first psychedelics will have to become available to medicine and psychiatry. And then it should be made available for such spiritual centers. Basically, all that we need to know we can learn from how the primitive people use psychedelics as sacraments, in a religious framework. We need such centers, but we also need the psychiatrists. These psychiatrists must become the Shamans of our times. Then I think we will be ready to move towards this kind of psychopharmacopeia.

CG: Back in the Sixties many people became frightened of LSD and other psychedelics, including many psychiatrists. Why was that?

AH: They did not use it the right way, and they did not have the right conditions. So, they were not adequately prepared for it. It is such a delicate and deep experience, if used the right way. But remember, the more powerful the instrument, the more the chance of damage occurring if it is not used properly. And back at that time, there were unfortunately many occasions where psychedelics were not treated with proper respect, and used in the wrong way, and consequently caused injury. That is the great tragedy, that these valuable medicines were not always respected and not always understood. So, the psychedelics came to be feared, and were taken out of the hands of responsible investigators and psychiatrists. It was a great loss for medicine and psychiatry, and for mankind. Hopefully, it is not too late to learn from these mistakes, and to demonstrate the proper and respectful way psychedelics should be used.

 
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Basel: The Birthplace of Psychedelic Science*

by Norman Miller | BBC | 13 Jul 2020

This Swiss city is where Albert Hofmann accidentally discovered the hallucinogenic properties of LSD, which transformed popular culture as well as psychology and brain science.

Talk of famous bike rides and you may think of Lycra-clad athletes racing in the Tour de France. But people worldwide also celebrate a much shorter bicycle journey made one April evening in 1943 by a suited 37-year-old man, clattering unsteadily home from work through the ancient streets of the Swiss city of Basel. This two-wheeled journey, you see, heralded the birth of psychedelia.

On the bicycle was pharmaceutical researcher Albert Hofmann, and he had just dosed himself with a new substance known at his lab as Lysergic Acid Diethylamide-25. But to everyone who followed, it was simply LSD.

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Basel was founded about 2,000 years ago on the banks of the Rhine.

Hofmann described his trippy trip home with an exactness of scientific observation that contrasts with the psychological wildness of the experience. “Kaleidoscopic, fantastic images surged in on me, alternating, variegated, opening and then closing themselves in circles and spirals, exploding in coloured fountains, rearranging and hybridizing themselves in constant flux,” he wrote in his book LSD – My Problem Child. “Every acoustic perception, such as the sound of a door handle or a passing automobile, became transformed into optical perceptions. Every sound generated a vividly changing image, with its own consistent form and colour.”

A very particular town

An ancient Swiss city isn't perhaps the obvious place to kick-start psychedelia. Switzerland, after all, is a nation stereotyped for pride in discreet banking and punctual trains. Orson Welles' character Harry Lime delivers a famous quip on its reputation in the classic 1949 film The Third Man: “In Switzerland they had brotherly love, they had 500 years of democracy and peace – and what did that produce? The cuckoo clock.”

Its medieval and Renaissance architecture gives Basel the outward appearance of other lovely middle European towns, but it has a distinctive DNA. Founded 2,000 years ago on the Rhine at the point present-day Switzerland meets both the French and German borders, the river was a watery information highway linking Basel to other European centres of learning. This may explain why Switzerland’s oldest university was founded here in 1460, augmented two centuries later by the world's oldest public art gallery – now the Kunstmuseum. During the Reformation, the arrival of silk dyers made Basel a place keen to work with chemicals.

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The original minutes of Albert Hofmann’s LSD experiment were exhibited at the Kunstmuseum Basel in 2018.

Basel today boasts more museums per person than any other city in Europe. “Basel has always been as a city where education, research and culture are part of the local fabric,” said Josef Helfenstein, director of the Kunstmuseum. “Sharing a border with Germany and France gives the city its special, more relaxed and open-minded spirit,” added Isidora Rudolph, head of Basel's tourism office. “There’s a certain ‘coolness’ and relaxed groove. Bank director and student alike, everybody loves to jump into the Rhine in summer, and then enjoy the unique savoir vivre [appreciation of life] that makes Basel so different.”

LSD's mundane origins

Strangely for such a mind-altering compound, LSD's discovery came during research by pharmaceutical firm Sandoz (now part of Novartis) to find plant-derived circulatory and respiratory stimulants. Hofmann's job was to isolate, purify and synthesise potentially interesting compounds from ergot, a rye fungus. Several of these involved lysergic acid, including one Hofmann discovered in 1938 – the one filed away as LSD-25.

And LSD's story might have ended right there as animal tests produced none of the effects Sandoz was looking for, just a strange restlessness in the animal subjects. “The new substance aroused no special interest in our pharmacologists and physicians,” Hofmann wrote. “Testing was therefore discontinued.”

It was five years before a nagging curiosity drove Hofmann to look again at LSD-25, spurred by strange childhood experiences that instilled a sense of mysticism. He described them in the foreword to his book LSD – My Problem Child.

“One enchantment...I experienced in childhood, has remained remarkably vivid in my memory ever since. It happened on a May morning...on a forest path on Martinsberg above Baden, Switzerland. As I strolled through the freshly greened woods filled with bird song and lit up by the morning sun, all at once everything appeared in an uncommonly clear light.... It shone with the most beautiful radiance, speaking to the heart, as though it wanted to encompass me in its majesty. I was filled with an indescribable sensation of joy, oneness, and blissful security.”

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Albert Hofmann synthesised LSD in 1938, while was working as a research chemist at Sandoz.

Hofmann continued: “While still a child, I experienced several more of these deeply euphoric moments on my rambles through forest and meadow. It was these experiences that shaped the main outlines of my world view and convinced me of the existence of a miraculous, powerful, unfathomable reality that was hidden from everyday sight.”

These thoughts clearly remained even after he donned a lab coat, as on the afternoon of 16 April 1943, Hofmann re-synthesized LSD-25 – a decision he explained in his 1996 lecture at the Worlds of Consciousness Conference in Germany as “no more than a hunch! I liked the chemical structure of the substance.” It was during the purification process that Hofmann believed he accidentally got some of the substance into his system.

Hit by a strange restlessness and dizziness, he stopped work for the day and went home to have the world's first acid trip. “I lay down and sank into a not unpleasant intoxicated-like condition, characterised by an extremely stimulated imagination,” he wrote. “In a dreamlike state... I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colours.”

When his Sandoz colleagues could offer no explanation, Hofmann decided to take a deliberate dose of LSD-25 three days later to experience its effects more consciously – unaware at the time that what he thought was a small dose (250 micrograms) was actually rather a lot.

LSD goes global

Once Europe emerged from World War Two, Sandoz marketed their new compound to researchers worldwide under the brand name Delysid. And for more than two decades, LSD was revealed as something of a wonder drug to treat anxiety, depression and psychological trauma. Between 1943 and 1970, Oxford University Press estimated it generated almost 10,000 scientific publications, earning the tag of the most intensively researched pharmacological substance ever.

In 1950s Cold War America, meanwhile, the CIA experimented with LSD as a brain-scrambling weapon in a project codenamed MK-ULTRA. They funded studies at universities like Columbia and Stanford, before deciding LSD's effects were simply too unpredictable for counter intelligence. At which point, creatives took up Hofmann's magical substance and put it at the heart of 1960s “acid” counterculture, at a time when it was legal and relatively easy to obtain.

LSD opened new doors of perception for diverse folk – from author Aldous Huxley and counterculture guru Timothy Leary to music legends like The Beatles, Jimi Hendrix and Bob Dylan. The Animals' 1967 song A Girl Called Sandoz openly sang its praises in lines like: “Well I met a girl called Sandoz, and she taught me many, many things.” On screen, LSD's influences infused films as different as Easy Rider and The Beatles' animation Yellow Submarine.

But the wheels came off the LSD bicycle when, in a political and moral panic over the drug's popularity with Vietnam War draft dodgers and “un-American” counterculture – epitomised by Timothy Leary's call for young people to “turn on, tune in, and drop out” – both the US and UK made recreational use of the substance illegal in the late 1960s, before hardening restrictions to include any government-sanctioned research through laws like 1970’s Controlled Substances Act in the US and Britain's 1973 Misuse of Drugs Act. But research into psychedelics was kept alive by a scattering of scientists worldwide, providing the seed for a surge of renewed interest as the new millennium dawned.

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Bicycle Day on 19 April commemorates Albert Hofmann intentionally taking LSD for the first time.

Bicycle Day

During LSD’s 1960s and ‘70s heyday, micro doses often bore stylised illustrations of Hofmann on his Basel bicycle, but it wasn't until 1985 that Illinois college professor Thomas B Roberts suggested people worldwide inspired by LSD – both scientifically or creatively – actively celebrate Albert's 1943 two-wheel ride home each April.

Typically, diverse celebrations mark Bicycle Day in Basel itself, combining trippy music, art events and science conferences showcasing the latest research into psychedelic compounds, plus bike rides inspired by Hofmann's transformative two-wheeled trip in 1943. Sandra Lang, a PhD researcher into the sociology of science, has run a guided Bicycle Day tour in Basel regularly in recent years, adding a colourful history of relevant chemistry information en route.

“I have reconstructed the route Albert Hoffmann took in 1943,” she said. “We usually start at the main gate of Novartis Campus – from the rear gate you can have a look inside the campus and see the lab building where the LSD self-experiment started off – at Lichtstrasse 35. Then you ride along Luzernerring, Wasgenring, Holeestrasse down to Bottmingen, where Albert Hofmann used to live.”

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American psychologist and author Timothy Leary was a leading advocate for the use of LSD.

Sadly, the actual house on Oberwilerstrasse where Hofmann experienced his world-changing LSD trips has been torn down, but the city renamed a nearby lane Albert-Hofmann-Rain in his honour in 2006.

Lang recommends riding the approximately 8.5km route on a weekend, when car traffic – almost non-existent during Hofmann's time due to wartime restrictions – is far less. As a perfect complement, delve further into Basel's chemical history at the city's Pharmaceutical Museum.

A new light on LSD

The 21st Century has seen a return to scientific research into LSD, with its therapeutic potential seen to outweigh ill-informed anti-drug laws. A driving force behind this renewal is Amanda Feilding, an English aristocrat (Countess of Wemyss and March) who is recognised today as a global leader in drug policy reform and co-ordinating research into psychedelics.

In 1996, Feilding founded the Beckley Foundation – initially, the Foundation for Further Consciousness – in Oxford, and it has since jump-started research not just into LSD, but also psilocybin (found in magic mushrooms), MDMA (ecstasy) and 5MeO-DMT (found in secretions from the Bufo alvarius toad of northern Mexico and some southern US states).

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Amanda Feilding began experimenting with LSD in the mid-1960s and is now working to change drug policy.

The Beckley Foundation teamed with London's Imperial College to initiate the first-ever brain imaging study with LSD, published in 2016. “The first images of the human brain on LSD revealed that it can help in ‘resetting’ the brain to overcome maladaptive pathways,” said Feilding.

In the US, meanwhile, research summed up by MAPS (Multidisciplinary Association for Psychedelic Studies) found LSD and other psychedelics can help problems as different as severe depression, searing cluster headaches and terror of dying among terminally-ill patients.

Fittingly, Switzerland is a leader in modern LSD research, including at Basel's University Hospital, where Matthias Liechti's research into psychedelics is revealing LSD’s ability to calm terrifying emotions associated with PTSD.

Humans have always taken substances that transform their feelings or impressions of the world, and some have serious negative effects. Medical News Today summed up some of the risks related to LSD in a 2017 article: “The danger lies in the unpredictability of the ‘trip’. The potency of the drug is unreliable, and individuals react differently to it. The user’s mindset, surroundings, stress level, expectations, thoughts and mood at the time the drug is taken, strongly influence the effects of the drug.”

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In 2018, the Swiss National Library in Bern hosted an exhibition entitled "LSD, the 75 Years of a Problem Child."

For some – particularly people with underlying issues of psychosis, anxiety or depression – LSD can act as a terrifying intensifier of those feelings. Even Hofmann experienced some scary moments, including perceiving a kindly female neighbour who knocked on his door during one of his famous “trips” as a malevolent witch figure.

But increasing research is suggesting the huge positive potential of LSD taken in an appropriate setting is significantly stronger than the risk of “bad trips” and long-term harm that may afflict some – just as the number of people who happily consume alcohol as a treasured pleasure far outweighs the number for whom it triggers violence, depression and terrible addiction.

And in a world where pain and terror are all too common, LSD’s transformational powers seem timely.

“LSD is such a subtle and misunderstood compound,” said Feilding. “As humans enter an era of general crisis, with epidemic levels of mental health problems, an ever-worsening ecological and socio-political state of affairs and a deepening spiritual vacuum, it is vital that we can better adapt our thoughts and behaviour.”

Time perhaps to open our minds to new ways.

 
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Albert Hofmann Quotes


Go to the meadows, go to the garden, go to the woods. Open your eyes!

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This possibility to change reality, which exists in everyone, represents the real freedom of every human individual. He has an enormous possibility to change his world view.

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I share the belief of many of my contemporaries that the spiritual crisis pervading all spheres of Western industrial society can be remedied only by a change in our world view. We shall have to shift from the materialistic, dualistic belief that people and their environment are separate, toward a new consciousness of an all-encompassing reality, which embraces the experiencing ego, a reality in which people feel their oneness with animate nature and all of creation.

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Evolution of mankind is paralleled by the increase and expansion of consciousness.

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LSD is just a tool to turn us into what we are supposed to be.

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Through my LSD experience and my new picture of reality, I became aware of the wonder of creation, the magnificence of nature and of the animal and plant kingdom. I became very sensitive to what will happen to all this and all of us.

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God only speaks to those who understand the language.

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I suddenly became strangely inebriated. The external world became changed as in a dream. Objects appeared to gain in relief; they assumed unusual dimensions; and colors became more glowing. Even self-perception and the sense of time were changed. When the eyes were closed, colored pictures flashed past in a quickly changing kaleidoscope. After a few hours, the not unpleasant inebriation, which had been experienced whilst I was fully conscious, disappeared. What had caused this condition?

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I believe that if people would learn to use LSD's vision-inducing capability more wisely, under suitable conditions, in medical practice and in conjunction with meditation, then in the future this problem child could become a wonderchild.

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LSD wanted to tell me something. It gave me an inner joy, an open mindedness, a gratefulness, open eyes and an internal sensitivity for the miracles of creation.

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What one commonly takes as 'the reality,' including the reality of one's own individual person, by no means signifies something fixed, but rather something that is ambiguous - that there is not only one, but that there are many realities, each comprising also a different consciousness of the ego.

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When you study natural science and the miracles of creation, if you don't turn into a mystic, you are not a natural scientist.

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Consciousness is God's gift to mankind.

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By observing natural scientific discoveries through a perception deepened by meditation, we can develop a new awareness of reality. This awareness could become the bedrock of a spirituality that is not based on the dogmas of a given religion, but on insights into a higher and deeper meaning. I am referring to the ability to recognize, to read, and to understand the firsthand revelations.

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I go back to where I came from, to where I was before I was born, that’s all.

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I was completely astonished by the beauty of nature. Our eyes see just a small fraction of the light in the world. It is a trick to make a colored world, which does not exist outside of human beings.

--

It's very, very dangerous to lose contact with living nature.

--

Our very essence is Absolute Consciousness; without an I. Without the consciousness of every individual, nothing really exists.

--

I think that in human evolution it has never been as necessary to have this substance LSD.

--

In a dreamlike state, with eyes closed (I found the daylight too unpleasantly glaring), I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors.

--

I know LSD; I don't need to take it anymore. Maybe when I die, like Aldous Huxley.

--

The characteristic property of hallucinogens, to suspend the boundaries between the experiencing self and the outer world in an ecstatic, emotional experience, makes it posible with their help, and after suitable internal and external perparation, to evoke a mystical experience according to plan, so to speak. I see the true importance of LSD in the possibility of providing material aid to meditation aimed at the mystical experience of a deeper, comprehensive reality. Such a use accords entirely with the essence and working character of LSD as a sacred drug.

--

Reality became for me a problem after my experience with LSD. Before, I had believed there was only one reality, the reality of everyday life. Just one true reality and the rest was imagination and was not real. But under the influence of LSD, I entered into realities which were as real and even more real than the one of everyday. And I thought about the nature of reality and I got some deeper insights.

--

After some time, with my eyes closed, I began to enjoy this wonderful play of colors and forms, which it really was a pleasure to observe. Then I went to sleep and the next day I was fine. I felt quite fresh, like a newborn.

--

We need a new concept of reality and a new set of values for things to change in a positive direction. LSD could help to generate such a new concept.

--

The productive sender is the outer world, the external reality including our own body. The receiver is our deep self, the conscious ego, which then transforms the outer stimuli into a psychological experience.

--

The truth will finally come out, and the truth is: If LSD is used in the right way, it is a very important and very useful agent.

--

We can study various psychic functions and also the more primitive sensory functions, such as seeing, hearing, and so on, which constitute our image of our everyday world. They have a material side and the psychic side. And that is a gap which you cannot explain.

--

People who use LSD today know how to use it. Therefore, I hope that the health authorities will get the insight that LSD, if it is used properly, is not a dangerous drug. We actually should not refer to it as drug; this word has a very bad connotation. We should use another name.

--

LSD is really just a small chemical modification of a very old sacred drug of Mexico. LSD belongs, therefore, by its chemical structure and by its activity, in the group of the magic plants of Mesoamerica. It does not occur in nature as such, but it represents just a small chemical variation of natural material.

--

We can study material processes and various processes at the energetic level, that is what we can do as natural scientists. And then there comes something quite different, the psychic experience, which remains a mystery.

--

It is true that my discovery of LSD was a chance discovery, but it was the outcome of planned experiments and these experiments took place in the framework of systematic pharmaceutical, chemical research. It could better be described as serendipity.

--

I became very sensitive to what will happen to all this and all of us.

--

LSD was my "wonder child", we had a positive reaction from everywhere in the world. Around two thousand publications about it appeared in scientific journals and everything was fine. Then, at the beginning of the 1960s, here in the United States, LSD became a drug of abuse. In a short time, this wave of popular use swept the country and it became "drug number one". It was then used without caution and people were not prepared and informed about its deep effects. Instead of a "wonder child", LSD suddenly became my "problem child".

--

LSD is no longer playing a bad role in the drug scene and psychiatrists are again trying to submit their proposals for research with this substance to the health authorities. I hope that LSD will again become available in the normal way, for the medical profession. Then it could play the role it really should, a beneficial role.

--

LSD should be treated as a sacred drug and receive corresponding preparation—preparation of quite a different kind than other psychotropic agents. It is one kind of thing if you have a pain-relieving substance or some euphoriant and (another to) have an agent that engages the very essence of human beings, their consciousness.

--

It is true that my discovery of LSD was a chance discovery, but it was the outcome of planned experiments and these experiments took place in the framework of systematic pharmaceutical, chemical research. It could better be described as serendipity. That means that you look for something, you have a certain plan, and then you find something else, different, that may nevertheless be useful.



 
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Hofmann's Potion - Albert Hofmann LSD Documentary​




By the mid-1950s, LSD-research was being published in medical and academic journals all over the world. It showed potential benefits in the treatment of alcoholism, drug addiction, and other mental illnesses. This film explores those potential benefits, and the researchers who explored them.​
 

The Philosopher's Stone - LSD documentary Part 1/2​




A unique documentary of the international symposium "LSD - Problem Child and Wonder Drug' (January 2006 in Basel, Switzerland) on the occasion of Dr. Albert Hofmanns's 100th birthday. This 5 hour documentary includes lectures presented by Albert Hofmann, Ralph Metzner, Alex Grey, Martin A. Lee and many more. These lectures describe and discuss the complex aspects of LSD.​
 

Albert Hofmann at age 100​

Closing speech in Basel, Switzerland​


 
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Albert Hofmann ponders his 'problem child'*

by Craig S. Smith | New York Times | 7 Jan 2006

Albert Hofmann, the father of LSD, walks slowly across the small corner office of his modernist home on a grassy Alpine hilltop here, hoping to show a visitor the vista that sweeps before him on clear days. But outside there is only a white blanket of fog hanging just beyond the crest of the hill.

Mr. Hofmann will turn 100 on Wednesday, a milestone to be marked by a symposium in nearby Basel on the chemical compound that he discovered and that famously unlocked the Blakean doors of perception, altering consciousnesses around the world. As the years accumulate behind him, Mr. Hofmann's conversation turns ever more insistently around one theme: man's oneness with nature and the dangers of an increasing inattention to that fact.

"It's very, very dangerous to lose contact with living nature," he said, listing to the right in a green armchair that looked out over frost-dusted fields and snow-laced trees. A glass pitcher held a bouquet of roses on the coffee table before him. "In the big cities, there are people who have never seen living nature, all things are products of humans," he said. "The bigger the town, the less they see and understand nature." And, yes, he said, LSD, which he calls his 'problem child, "could help reconnect people to the universe."

Rounding a century, Mr. Hofmann is physically reduced but mentally clear. He is prone to digressions, ambling with pleasure through memories of his boyhood, but his bright eyes flash with the recollection of a mystical experience he had on a forest path more than 90 years ago in the hills above Baden, Switzerland. The experience left him longing for a similar glimpse of what he calls "a miraculous, powerful, unfathomable reality."

"I was completely astonished by the beauty of nature,"
he said, laying a slightly gnarled finger alongside his nose, his longish white hair swept back from his temples and the crown of his head. He said "any natural scientist who was not a mystic is not a real natural scientist. Outside is pure energy and colorless substance," he said. "All of the rest happens through the mechanism of our senses. Our eyes see just a small fraction of the light in the world. It is a trick to make a colored world, which does not exist outside of human beings."

He became particularly fascinated by the mechanisms through which plants turn sunlight into the building blocks for our own bodies. "Everything comes from the sun via the plant kingdom," he said.

Mr. Hofmann studied chemistry and took a job with the Swiss pharmaceutical company Sandoz Laboratories, because it had started a program to identify and synthesize the active compounds of medically important plants. He soon began work on the poisonous ergot fungus that grows in grains of rye. Midwives had used it for centuries to precipitate childbirths, but chemists had never succeeded in isolating the chemical that produced the pharmacological effect. Finally, chemists in the United States identified the active component as lysergic acid, and Mr. Hofmann began combining other molecules with the unstable chemical in search of pharmacologically useful compounds.

His work on ergot produced several important drugs, including a compound still in use to prevent hemorrhaging after childbirth. But it was the 25th compound that he synthesized, lysergic acid diethylamide, that was to have the greatest impact. When he first created it in 1938, the drug yielded no significant pharmacological results.

But when his work on ergot was completed, he decided to go back to LSD-25, hoping that improved tests could detect the stimulating effect on the body's circulatory system that he had expected from it. It was as he was synthesizing the drug on a Friday afternoon in April 1943 that he first experienced the altered state of consciousness for which it became famous. "Immediately, I recognized it as the same experience I had had as a child," he said. "I didn't know what caused it, but I knew that it was important."

When he returned to his lab the next Monday, he tried to identify the source of his experience, believing first that it had come from the fumes of a chloroform-like solvent he had been using. Inhaling the fumes produced no effect, though, and he realized he must have somehow ingested a trace of LSD.
"LSD spoke to me," Mr. Hofmann said with an amused, animated smile. "He came to me and said, 'You must find me.' He told me, 'Don't give me to the pharmacologist, he won't find anything.' "

HE experimented with the drug, taking a dose so small that even the most active toxin known at that time would have had little or no effect. The result with LSD, however, was a powerful experience, during which he rode his bicycle home, accompanied by an assistant. That day, April 19, later became memorialized by LSD enthusiasts as "bicycle day."

Mr. Hofmann participated in tests in a Sandoz laboratory, but found the experience frightening and realized that the drug should be used only under carefully controlled circumstances. In 1951, he wrote to the German novelist Ernst Junger, who had experimented with mescaline, and proposed that they take LSD together. They each took 0.05 milligrams of pure LSD at Mr. Hofmann's home accompanied by roses, music by Mozart and burning Japanese incense. "That was the first planned psychedelic test," Mr. Hofmann said.

He took the drug dozens of times after that, he said, and once experienced what he called a "horror trip" when he was tired and Mr. Junger gave him amphetamines first. But his psychedelic days are long behind him.

"I know LSD; I don't need to take it anymore," Mr. Hofmann said. "Maybe when I die, like Aldous Huxley," who asked his wife for an injection of LSD to help him through the final painful throes of his fatal throat cancer.

But Mr. Hofmann calls LSD "medicine for the soul" and is frustrated by the worldwide prohibition that has pushed it underground. "It was used very successfully for 10 years in psychoanalysis," he said, adding that the drug was hijacked by the youth movement of the 1960's and then demonized by the establishment that the movement opposed.

"It should be a controlled substance with the same status as morphine," he said.

Mr. Hofmann lives with his wife in the house they built 38 years ago. He raised four children and watched one son struggle with alcoholism before dying at 53. He has eight grandchildren and six great-grandchildren. As far as he knows, no one in his family besides his wife has tried LSD.

Mr. Hofmann rose, slightly stooped and now barely reaching five feet, and walked through his house with his arm-support cane. When asked if the drug had deepened his understanding of death, he appeared mildly startled and said no. "I go back to where I came from, to where I was before I was born, that's all," he said.

*From the article here :
 
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What is Bicycle Day – the world’s biggest psychedelic holiday?

by Natan Ponieman | Healing Maps | 15 Mar 2022

Bicycle Day is an annual “holiday” on April 19 that psychedelic enthusiasts celebrate. However, Bicycle Day is more than just that, as it represents a major event in psychedelic history.

April 19 is the day that the effects of LSD (lysergic acid diethylamide) were discovered by Swiss chemist Albert Hofmann. It was on that date in 1943 that Hofmann experienced LSD for the first time in human history. After taking the psychedelic, he went for a bike ride, testing the drug’s effects on himself.

Unfortunately, Hofmann’s experience that afternoon was not as pleasant as some might imagine. But this did not prevent the scientist from continuing his research into LSD’s therapeutic properties.

In the decades to follow, Hoffman’s research remains influential on culture, politics and science.

What is Bicycle Day?

So, what is Bicycle Day? Arguably, the world’s biggest psychedelic holiday, a professor from Northern Illinois University, Thomas Roberts, began celebrating it in 1985. It takes its name from the legendary experiment of 1943, in which Albert Hoffmann took a bike ride after ingesting a large dose of LSD and discovering its hallucinogenic effects.

Since then, Bicycle Day has spread around the world, becoming a celebration recognizing a pivotal point in the history of psychedelic experimentation. Indeed, a new era in chemistry, medicine, culture, arts and philosophy started after that day in which Hofmann made a guinea pig of himself for his own research.

Bicycle Day represents the opening of a doorway to a richer understanding of human consciousness. In the words of Hofmann, LSD is to be a sacred tool that can help its users attain “a deeper, comprehensive reality.”

This potential rapidly drew attention to psychiatrists and neurophysiologists. In fact, throughout the 1950s and 1960s, many researchers in those fields studied the use of LSD to treat schizophrenia, alcoholism, anxiety, depression and other mental health issues.

Many of these trials, unfortunately, were abandoned because of federal prohibitions led by the infamous War on Drugs in the 1960s and 1970s.

Another impact on psychedelic experimentations with LSD? The hippie movement and the cultural revolution of the 1960s. Many artists, musicians, intellectuals and bohemians in those days took LSD for creative use, which greatly impacted the course of cultural history.

However, Hofmann didn’t imagine the impact of his discovery when he started studying LSD in the late 1930s.

Who is Albert Hofmann?

Albert Hofmann was the first person to synthesize, ingest and study LSD. His research started in 1938, in the pharmaceutical department of Sandoz Laboratories in Basel, Switzerland, while he was studying ergot, a fungus that usually grows on rye, from which he synthesized LSD as a potential stimulant for treating circulatory and respiratory diseases.

At first, he tested the new substance on sedated animals, but he didn’t find interesting results in those experiments. That’s the reason why his research was shelved until five years after, when he decided to continue studying LSD.

On April 16, 1943, Hofmann synthesized a new batch of “the wonder drug LSD.” While working on that process, he started feeling strange. He decided to interrupt his job and go back home.

Upon arrival, as he points in his memoir LSD – My Problem Child, he “sank into a not unpleasant intoxicated-like condition, characterized by an extremely stimulated imagination.” Therefore, he thought that an accidental contact with the substance might have caused the weird experience. He decided to take a dose to experiment on himself.

On April 19, Hofmann voluntarily took 250 micrograms of LSD — which is a strong dose. By comparison, the Global Drug Survey recommends between 100 and 200 micrograms. Hoffman then realized that “altered perceptions were of the same type as before, only much more intense.”

After suffering speech difficulties, he believed he had poisoned himself, asking his assistant to help him get home.

Due to restrictions of Second World War times prohibiting the use of cars, they took a bicycle ride to Hofmann’s house. While pedaling, the impact of the LSD hit Hofmann’s system. The trip became a nightmare. Per his memoir, Hoffman said it felt as if a demon “had taken possession of my body, mind and soul.”

At home, he was able to relax and fall asleep. The morning after, he woke up feeling himself to be “in excellent physical and mental conditions.”

A “sensation of well-being and renewed life” flowed through him. From his own experience, Hoffman claims that research on LSD would be valuable to pharmacology and medicine. And from his infamous bike ride, Bicycle Day was born.

Thus, Hofmann continued his experiments on LSD, and this set the stage for the psychedelic revolution that would take place more than a decade later.

 
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LSD as a Spiritual Aid

by Thomas B. Roberts | Inner Traditions | 7 Jun 2012

Albert Hofmann, Ph.D., Dr.Pharm.H.C., Dr.Sc.Nat.H.C., is best known for his serendipitous discovery of LSD and for his chemical work identifying the active principles of the sacred mushroom of Mexico. He was the retired director of research for the Department of Natural Products at Sandoz Pharmaceutical Ltd. in Basel, Switzerland. Dr. Hofmann was a fellow of the World Academy of Science and a member of the Nobel Prize Committee, the International Society of Plant Research, and the American Society of Pharmacognosy. He wrote many scientific papers and several books: The Botany and Chemistry of Hallucinogens and Plants of the Gods with Richard Evans Schultes, The Road to Eleusis with R. G. Wasson and Carl Ruck, LSD: My Problem Child, and Insight/Outlook.

Born January 11, 1906, Albert celebrated his 100th birthday in excellent health with thousands of grateful admirers at the Spirit of Basel — a celebration of his life’s work (www.lsd.info/en/home.html). Albert died two years later, on April 29, 2008, four months after his wife, Anita, had passed away. His archives and legacy are managed by Dieter Hagenbach at www.gaiamedia.org. Following are Dr. Hofmann's comments on the the role LSD played in his spiritual development.

-----

"Before I start with the report on the role LSD has played in my spiritual development, some general remarks on this very special psychopharmacon are appropriate."

"LSD is not a product of planned research. I did not look for it, it came to me. This means to me that a higher authority thought it was necessary now to provide mankind with an additional pharmacological aid for spiritual growth."

"LSD is not just a synthetic substance from the laboratory. After the discovery of lysergic acid amide and lysergic acid hydroxyethylamide (very closely related to lysergic acid diethylamide) as the entheogenic principles of Ololiuqui, an ancient sacred plant of Mexican Indians, LSD had to be regarded as belonging to the group of natural entheogenic drugs of Mesoamerica."

"These two characteristics of LSD legitimate its use in a religious framework."

"Now I come to the report of how LSD was a spiritual aid to me and how it influenced my worldview (Weltanschauung)."

"After my first experiences with LSD, the question arose for me: Which is true, the picture of the world as we perceive it with our everyday consciousness or the overwhelming image under the influence of entheogens?"

"This caused me to analyze what we know about the mechanism of perceiving reality."

"Perception presupposes a subject that perceives and an object that is perceived. In human relations the subject that perceives is the individual human being, more exactly his consciousness, and the object perceived is the outer material world."

"It is of the greatest importance to be aware of the fundamental fact that the outer world consists objectively of nothing more than matter and energy."

"In order to make conspicuous the mechanism of our experiencing reality, I have chosen a metaphor from television. The material world functions as transmitter, emanates optical, acoustical, gustatory, olfactory, and tactile signals that are received by the antennae, by our sensory organs, eyes, ears, tongue, nose, and skin and are conducted from there to the corresponding center in the brain to the receiver. There these energetic and material signals are transformed into the spiritual phenomena of seeing, hearing, tasting, smelling, and touching. One does not know how this transformation of material and energetic impulses into the psychic dimension of perception takes place. It includes the mystery of the connection between the material and the spiritual world."

"The transmitter-receiver metaphor of reality makes evident that the picture of the outer world comes into existence inside, in the consciousness of the individual."

"This fundamental fact signifies that the screen on which the colorful world is perceived is not in the outer but in the inner space of every human being. There are no colors, no sounds, no taste, no odors in the outer world. Everyone carries within himself his own personal image of the world, an image created by his private receiver. There is no common screen outside. This makes us fully aware of the cosmogenic (worldcreating) power invested in every human."

"Before making use of these considerations to explain the ability of LSD and the other entheogens to change the experience of reality, our knowledge about the essence of consciousness must be reviewed."

"Consciousness defies a scientific definition and explanation; for it is what is needed to contemplate what consciousness is. It can only be circumscribed as being the receptive and creative center of the spiritual ego, which has the faculties of perceiving, thinking, and feeling, and which is the seat of memory."

"It is of fundamental importance to be aware of how consciousness originates and develops."

"The newborn human possesses solely the faculty of perceiving — possesses, or more correctly, is this mystic nucleus of life. He owns — to use again the metaphor of television — a blank videocassette, where the incoming stimuli from the outer world are transformed into images and sensations that can then be stored in the memory, providing the groundwork for thinking. Without these signals from outside, no consciousness could develop."

"There is common consent that the evolution of mankind is paralleled by the increase and expansion of consciousness. From the described process of how consciousness originates and develops, it becomes evident that its growth depends on its faculty of perception."

"Therefore every means of improving this faculty should be used."

"The characteristics of entheogens, their faculty to improve sensory perception, makes them inestimable aids in the process of expanding consciousness."

"It was LSD, the most potent entheogen, that, to use Blake’s famous line, cleansed my doors of perception and made me see everything as it is, infinite."

"In my childhood I experienced spontaneously some of those blissful moments when the world appeared suddenly in a new brilliant light, and I had the feeling of being included in its wonder and indescribable beauty. These moments remained in my memory as extraordinary experiences of untold happiness, but only after the discovery of LSD did I grasp their meaning and existential importance."

"As mentioned at the beginning of this short essay, it was my experiences with LSD that caused me to think about the essence of reality. The insights I received, as described, increased my astonishment about the wonder of existence, of which we become conscious in enlightened moments."


 
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Eleusis

Mystery and Myth

Last chapter of Hofmann's book LSD - My Problem Child

The notion of reality as the self juxtaposed to the world, in confrontation with the outer world, began to form itself, as reported in the citation from Benn, in the southern portion of the European continent in Greek antiquity. No doubt people at that time knew the suffering that was connected with such a cleft reality consciousness. The Greek genius tried the cure, by supplementing the multiformed and richly colored, sensual as well as deeply sorrowful Apollonian world view created by the subject/object cleavage, with the Dionysian world of experience, in which this cleavage is abolished in ecstatic inebriation. Nietzsche writes in The Birth of Tragedy:

It is either through the influence of narcotic potions, of which all primitive peoples and races speak in hymns, or through the powerful approach of spring, penetrating with joy all of nature, that those Dionysian stirrings arise, which in their intensification lead the individual to forget himself completely.... Not only does the bond between man and man come to be forged once again by the magic of the Dionysian rite, but alienated, hostile, or subjugated nature again celebrates her reconciliation with her prodigal son, man.

The Mysteries of Eleusis, which were celebrated annually in the fall, over an interval of approximately 2,000 years, from about 1500 B.C. until the fourth century A.D., were intimately connected with the ceremonies and festivals in honor of the god Dionysus. These Mysteries were established by the goddess of agriculture, Demeter, as thanks for the recovery of her daughter Persephone, whom Hades, the god of the underworld, had abducted. A further thank offering was the ear of grain, which was presented by the two goddesses to Triptolemus, the first high priest of Eleusis. They taught him the cultivation of grain, which Triptolemus then disseminated over the whole globe. Persephone, however, was not always allowed to remain with her mother, because she had taken nourishment from Hades, contrary to the order of the highest gods. As punishment she had to return to the underworld for a part of the year. During this time, it was winter on the earth, the plants died and were withdrawn into the ground, to awaken to new life early in the year with Persephone's journey to earth.

The myth of Demeter, Persephone, Hades, and the other gods, which was enacted as a drama, formed, however, only the external framework of events. The climax of the yearly ceremonies, which began with a procession from Athens to Eleusis lasting several days, was the concluding ceremony with the initiation, which took place in the night. The initiates were forbidden by penalty of death to divulge what they had learned, beheld, in the innermost, holiest chamber of the temple, the telesterion (goal). Not one of the multitude that were initiated into the secret of Eleusis has ever done this. Pausanias, Plato, many Roman emperors like Hadrian and Marcus Aurelius, and many other known personages of antiquity were party to this initiation. It must have been an illumination, a visionary glimpse of a deeper reality, an insight into the true basis of the universe. That can be concluded from the statements of initiates about the value, about the importance of the vision. Thus it is reported in a Homeric Hymn: "Blissful is he among men on Earth, who has beheld that! He who has not been initiated into the holy Mysteries, who has had no part therein, remains a corpse in gloomy darkness." Pindar speaks of the Eleusinian benediction with the following words: "Blissful is he, who after having beheld this enters on the way beneath the Earth. He knows the end of life as well as its divinely granted beginning." Cicero, also a famous initiate, likewise put in first position the splendor that fell upon his life from Eleusis, when he said: "Not only have we received the reason there, that we may live in joy, but also, besides, that we may die with better hope."

How could the mythological representation of such an obvious occurrence, which runs its course annually before our eyes—the seed grain that is dropped into the earth, dies there, in order to allow a new plant, new life, to ascend into the light—prove to be such a deep, comforting experience as that attested by the cited reports? It is traditional knowledge that the initiates were furnished with a potion, the kykeon, for the final ceremony. It is also known that barley extract and mint were ingredients of the kykeon. Religious scholars and scholars of mythology, like Karl Kerenyi, from whose book on the Eleusinian Mysteries the preceding statements were taken, and with whom I was associated in relation to the research on this mysterious potion [In the English publication of Kerenyi's book Eleusis a reference is made to this collaboration] are of the opinion that the kykeon was mixed with an hallucinogenic drug. [In The Road to Eleusis by R. Gordon Wasson, Albert Hofmann, and Carl A. P. Ruck the possibility is discussed that the kykeon could have acted through an LSD-like preparation of ergot.] That would make understandable the ecstatic-visionary experience of the DemeterPersephone myth, as a symbol of the cycle of life and death in both a comprehensive and timeless reality.

When the Gothic king Alarich, coming from the north, invaded Greece in 396 A.D. and destroyed the sanctuary of Eleusis, it was not only the end of a religious center, but it also signified the decisive downfall of the ancient world. With the monks that accompanied Alarich, Christianity penetrated into the country that must be regarded as the cradle of European culture.

The cultural-historical meaning of the Eleusinian Mysteries, their influence on European intellectual history, can scarcely be overestimated. Here suffering humankind found a cure for its rational, objective, cleft intellect, in a mystical totality experience, that let it believe in immortality, in an everlasting existence.

This belief had survived in early Christianity, although with other symbols. It is found as a promise, even in particular passages of the Gospels, most clearly in the Gospel according to John, as in Chapter 14: 120. Jesus speaks to his disciples, as he takes leave of them:

And I will pray to the Father, and he shall give you another Comforter, that he may abide with you forever;

Even the Spirit of truth;
whom the world cannot receive, because it seeth him not, neither knoweth him: but ye know him; for he dwelleth with you, and shall be in you.

I will not leave you comfortless: I will come to you. Yet a little while, and the world seeth me no more; but ye see me: because I live, ye shall live also.

At that day ye shalt know that I am in my Father, and ye in me, and I in you.


This promise constitutes the heart of my Christian beliefs and my call to natural-scientific research: we will attain to knowledge of the universe through the spirit of truth, and thereby to understanding of our being one with the deepest, most comprehensive reality, God.

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Ecclesiastical Christianity, determined by the duality of creator and creation, has, however, with its nature-alienated religiosity largely obliterated the Eleusinian-Dionysian legacy of antiquity. In the Christian sphere of belief, only special blessed men have attested to a timeless, comforting reality, experienced in a spontaneous vision, an experience to which in antiquity the elite of innumerable generations had access through the initiation at Eleusis. The unio mystica of Catholic saints and the visions that the representatives of Christian mysticism—Jakob Boehme, Meister Eckhart, Angelus Silesius, Thomas Traherne, William Blake, and others—describe in their writings, are obviously essentially related to the enlightenment that the initiates to the Eleusinian Mysteries experienced.

The fundamental importance of a mystical experience, for the recovery of people in Western industrial societies who are sickened by a one-sided, rational, materialistic world view, is today given primary emphasis, not only by adherents to Eastern religious movements like Zen Buddhism, but also by leading representatives of academic psychiatry. Of the appropriate literature, we will here refer only to the books of Balthasar Staehelin, the Basel psychiatrist working in Zurich. [Haben und Sein (1969), Die Welt als Du (1970), Urvertrauen und zweite Wirklichkeit (1973), and Der flnale Mensch (1976); all published by Theologischer Verlag, Zurich.] They make reference to numerous other authors who deal with the same problem. Today a type of "metamedicine," "metapsychology," and "metapsychiatry" is beginning to call upon the metaphysical element in people, which manifests itself as an experience of a deeper, duality-surmounting reality, and to make this element a basic healing principle in therapeutic practice.

In addition, it is most significant that not only medicine but also wider circles of our society consider the overcoming of the dualistic, cleft world view to be a prerequisite and basis for the recovery and spiritual renewal of occidental civilization and culture. This renewal could lead to the renunciation of the materialistic philosophy of life and the development of a new reality consciousness.

As a path to the perception of a deeper, comprehensive reality, in which the experiencing individual is also sheltered, meditation, in its different forms, occupies a prominent place today. The essential difference between meditation and prayer in the usual sense, which is based upon the duality of creator creation, is that meditation aspires to the abolishment of the I-you-barrier by a fusing of object and subject, of sender and
receiver, of objective reality and self.

Objective reality, the world view produced by the spirit of scientific inquiry, is the myth of our time. It has replaced the ecclesiastical-Christian and mythical-Apollonian world view.

But this ever broadening factual knowledge, which constitutes objective reality, need not be a desecration. On the contrary, if it only advances deep enough, it inevitably leads to the inexplicable, primal ground of the universe: the wonder, the mystery of the divine—in the microcosm of the atom, in the macrocosm of the spiral nebula; in the seeds of plants, in the body and soul of people.

Meditation begins at the limits of objective reality, at the farthest point yet reached by rational knowledge and perception. Meditation thus does not mean rejection of objective reality; on the contrary, it consists of a penetration to deeper dimensions of reality. It is not escape into an imaginary dream world; rather it seeks after the comprehensive truth of objective reality, by simultaneous, stereoscopic contemplation of its surfaces and depths.

It could become of fundamental importance, and be not merely a transient fashion of the present, if more and more people today would make a daily habit of devoting an hour, or at least a few minutes, to meditation. As a result of the meditative penetration and broadening of the natural-scientific world view, a new, deepened reality consciousness would have to evolve, which would increasingly become the property of all humankind. This could become the basis of a new religiosity, which would not be based on belief in the dogmas of various religions, but rather on perception through the "spirit of truth." What is meant here is a perception, a reading and understanding of the text at first hand, "out of the book that God's finger has written" (Paracelsus), out of the creation.

The transformation of the objective world view into a deepened and thereby religious reality consciousness can be accomplished gradually, by continuing practice of meditation. It can also come about, however, as a sudden enlightenment; a visionary experience. It is then particularly profound, blessed, and meaningful. Such a mystical experience may nevertheless "not be induced even by decade-long meditation," as Balthasar Staehelin writes. Also, it does not happen to everyone, although the capacity for mystical experience belongs to the essence of human spirituality.

Nevertheless, at Eleusis, the mystical vision, the healing, comforting experience, could be arranged in the prescribed place at the appointed time, for all of the multitudes who were initiated into the holy Mysteries. This could be accounted for by the fact that an hallucinogenic drug came into use; this, as already mentioned, is something that religious scholars believe.

The characteristic property of hallucinogens, to suspend the boundaries between the experiencing self and the outer world in an ecstatic, emotional experience, makes it possible with their help, and after suitable internal and external preparation, as it was accomplished in a perfect way at Eleusis, to evoke a mystical experience according to plan, so to speak.

Meditation is a preparation for the same goal that was aspired to and was attained in the Eleusinian Mysteries. Accordingly it seems feasible that in the future, with the help of LSD, the mystical vision, crowning meditation, could be made accessible to an increasing number of practitioners of meditation.

I see the true importance of LSD in the possibility of providing material aid to meditation aimed at the mystical experience of a deeper, comprehensive reality. Such a use accords entirely with the essence and working character of LSD as a sacred drug.

 
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Who was Albert Hofmann?*

by Jeff Glorfeld | COSMOS | 28 May 2022

In a 2007 article, Britain’s Daily Telegraph newspaper named Swiss chemist Albert Hofmann and Tim Berners-Lee, the British computer scientist often called the inventor of the internet, as equal first in its list of the “top 100 living geniuses.”

To most people, Hofmann is primarily known as the man who first synthesised the crystalline compound lysergic acid diethylamide, the hallucinogenic drug better known as LSD.

But far more than an avatar of “acid”, as the drug became commonly known, Hofmann was an inspired chemist with many important discoveries to his name.

He was born in Baden, in northern Switzerland, on January 11, 1906. He studied chemistry at Zurich University, he said, because “he wanted to explore the natural world at the level where energy and elements combine to create life”, the New York Times wrote in its obituary for Hofmann, published on April 30, 2008.

He earned his PhD in Zurich in 1929 and then took a job with Sandoz Laboratories in Basel, attracted by a program there that sought to synthesise pharmacological compounds from medicinal plants.

The Telegraph described some of Hofmann’s less flamboyant discoveries, including hydergine, a substance for improving circulation and cerebral function, and dihydergot, a circulation and blood-pressure stabilising medicine.

His interest in synthesising LSD initially derived from the hope that it might also be useful as a circulatory and respiratory stimulant.

In the forward to his best-known book, LSD: My Problem Child, published in 1979, Hofmann described a childhood experience in a forest on a May morning in Switzerland: “I was filled with an indescribable sensation of joy, oneness, and blissful security.”

He continued: “I was often troubled in those days, wondering if I would ever, as an adult, be able to communicate these experiences … Because I wanted to gain insight into the structure and essence of matter, I became a research chemist.”

Off and on for some time he’d been working on a substance he called LSD-25. On April 16, 1943, he experienced an “accidental” dosing of the substance. In the book, Hofmann provided his laboratory journal entry for April 19, 1943, the day he intentionally tested LSD on himself.

4/19/43 16:20: 0.5 cc of 1/2 promil aqueous solution of diethylamide tartrate orally = 0.25 mg tartrate. Taken diluted with about 10 cc water. Tasteless.

17:00: Beginning dizziness, feeling of anxiety, visual distortions, symptoms of paralysis, desire to laugh.

Supplement of 4/21: Home by bicycle. From 18:00- ca.20:00 most severe crisis.


Since 1985, fans of Hofmann’s discovery have celebrated April 19 as “Bicycle Day.”

In a 2006 interview, the New York Times reported, Hofmann said that LSD had not affected his understanding of death. In death, he said, ‘I go back to where I came from, to where I was before I was born, that’s all’.”

Albert died at his home, near Basel, Switzerland on April 29, 2008. He was 102.

*From the article here :
 
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