JohnBoy2000
Bluelighter
- Joined
- May 11, 2016
- Messages
- 2,473
Stahls book brings up more than once that, in agents where there is a dual mechanism of action, the normally requisite 90% occupancy of NE receptors required for efficacy, may be significantly reduced - due to the dual mechanisms of action.
Venlafaxine is waaay more selective for 5HT.
Desvenlafaxine?
I'm not sure.
Duloxetine - this interests me - as the binding profile is stronger for 5HT but, clinical observations suggest the effects on each transmitter is roughly equal.
Milnaciprane - not approved for depression but - one of the few agents that has dual action, but more selective for NE.
Any opinions on that?
Bupropion - remains an anomaly in my mind, but supposedly having DA actions as well as NE, perhaps meets the requisite for dual action, thus, less required NE receptor occupancy.
When I tried it before though, I experienced the immediate "buproprion honeymoon", then it faded - which would be consistent with cathinone tolerance.
And to hell with anything with mACh actions.
Cardiac implications of those are just too hard for me.
Opinions on them or alternate suggestions?
Duloxetine in particular - anyone tried it?
Venlafaxine is waaay more selective for 5HT.
Desvenlafaxine?
I'm not sure.
Duloxetine - this interests me - as the binding profile is stronger for 5HT but, clinical observations suggest the effects on each transmitter is roughly equal.
Milnaciprane - not approved for depression but - one of the few agents that has dual action, but more selective for NE.
Any opinions on that?
Bupropion - remains an anomaly in my mind, but supposedly having DA actions as well as NE, perhaps meets the requisite for dual action, thus, less required NE receptor occupancy.
When I tried it before though, I experienced the immediate "buproprion honeymoon", then it faded - which would be consistent with cathinone tolerance.
And to hell with anything with mACh actions.
Cardiac implications of those are just too hard for me.
Opinions on them or alternate suggestions?
Duloxetine in particular - anyone tried it?