C6H6
Bluelighter
- Joined
- Jan 29, 2005
- Messages
- 607
fastandbulbous said:why does an alpha-methyl group sticking out seem to increase potency
Because it inhibits metabolism to the inactive compounds (it's why 2,4,5-trimwthoxyamphetamine is active, but 2,4,5-trimethoxyphenethylamine isn't). Means that more of the drug actually makes it to the brain. It appears that the alpha methyl group is acceptable, but increasing it to an ethyl group really hinders receptor binding
I don't think that inhibition of metabolism is all, because then 2C-D would attain the potency of DOM if taken while on MAOIs. This is not the case. 2C-D acts somewhat longer if MAO A & B are inhibited (by moclobemide and selegeline), but potency is not increased.
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