thinkforyourself
Greenlighter
- Joined
- Oct 15, 2019
- Messages
- 2
My main question here is what is the deal with this substance. My current goal is to cure my HPPD and OCD and find something to ground me in reality aka mindfulness
This substance looks promising for quite a few brain issues, but there has been extensive studies on mice and zero on humans. Well here ya go human guinea pig right here. It mimics BDNF, crosses the BBB, TrKB agonist. Some brain healing and neuro plasticity potential? I believe this substance looks promising enough that I figured I’d write my experience as the ones I’ve found on reddit were pretty lame. Also I don’t know shit about science this stuff just interests me and I’m trying to heal my brain.
day one, 20mg orally, instant energy boost with an almost opiate like surge lasting 1min (placebo?), Energy boost, felt it easier to be mindful more grounded in reality tho not particularly sharp, found myself less nervous in pressure situations. Turned my leg bounce into a foot-tap (psychologists?), started thinking in “I” statements rather than “you’s” (psychologists?) ingested alcohol and the drunk was very pleasant tho less tolerant than usual but in a strange way as if I was getting all the good benefits of alcohol without the negative but worse motor function (turns out this is an inhibitor of some alcohol metabolizing enzyme aldehyde endeogense or somethin, some redditor claims). Can’t sleep
www.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
www.sciencedirect.com
This substance looks promising for quite a few brain issues, but there has been extensive studies on mice and zero on humans. Well here ya go human guinea pig right here. It mimics BDNF, crosses the BBB, TrKB agonist. Some brain healing and neuro plasticity potential? I believe this substance looks promising enough that I figured I’d write my experience as the ones I’ve found on reddit were pretty lame. Also I don’t know shit about science this stuff just interests me and I’m trying to heal my brain.
day one, 20mg orally, instant energy boost with an almost opiate like surge lasting 1min (placebo?), Energy boost, felt it easier to be mindful more grounded in reality tho not particularly sharp, found myself less nervous in pressure situations. Turned my leg bounce into a foot-tap (psychologists?), started thinking in “I” statements rather than “you’s” (psychologists?) ingested alcohol and the drunk was very pleasant tho less tolerant than usual but in a strange way as if I was getting all the good benefits of alcohol without the negative but worse motor function (turns out this is an inhibitor of some alcohol metabolizing enzyme aldehyde endeogense or somethin, some redditor claims). Can’t sleep
7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders
Brain-derived neurotrophic factor (BDNF) regulates a variety of biological processes predominantly via binding to the transmembrane receptor tyrosine kinase TrkB. It is a potential therapeutic target in numerous neurological, mental and metabolic disorders. ...
www.ncbi.nlm.nih.gov
The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease - PubMed
The BDNF mimetic compound 7,8-dihydroxyflavone (7,8-DHF), a potent small molecular TrkB agonist, displays prominent therapeutic efficacy against Alzheimer's disease (AD). However, 7,8-DHF has only modest oral bioavailability and a moderate pharmacokinetic (PK) profile. To alleviate these...
www.ncbi.nlm.nih.gov
