I recently tried a first-time combo of 6-APB/5-APB @ 110mg, 60/50 respectively.
Age: 31, WM
Weight: 185 lbs, <12% bf
Lifestyle: Healthy eater, gym 5-6 x per week.
Positives:
It was mindblowing and quite enjoyable. Rapid release of serotonin and some dopamine, yet didn't have as much cerebral effect as mdma. The experience lasted 8+ hours. No severe comedown, just a peak and gentle descent into baseline territory from about T+ 5 hours. Visual effects were present but not overwhelming. Euphoria was intense, although I never 'lost' my head. Day after was not too bad, but I supplemented with 5-htp, ALA, vit C, and SAM-e.
Negatives:
As a medical student, I will tell you with confidence this stuff can cause nephropyelitis, thermal regulation issues, anhydrosis, and increased blood pressure. BE CAREFUL! My subjective report will focus on the potential primary causes of this tree of symptoms, and then explain in further detail the possible mechanisms of action of these side-effects.
(The 5-ABP/6-ABP combo I took was bought from a reputable distributor and hand weighed on precise digital scales.)
1. Cerebellar function was markedly impaired. I noticed balance and coordination issues, along with relay problems likely caused by hypothalamic interference.
2. Components of the brain stem (pons, medulla, midbrain) were also effected by the drug. Hyperthermia was noted, although neither me or my friend (also a med student) were sweating. The anhydrosis concerned both of us, but what followed was more concerning. I developed some flank pain about T +1.5, and in spite of drinking nearly a liter of water, was only able to urinate once in a 7 hour period. Flank pain increased as the night progressed. Erythema/edema in my extremities began to occur intermittently. As the drug wore off, we both noted excessive body heat with continued anhydrosis. Gradually, urination came back, but I pissed a dark orange several times before returning to normal urinary habits (possible breakdown of kidney tissues).
3.Sympathetic/parasympathetic problems:
Combined erratic regulation of sympathetic and parasympathetic nervous system. Our eyeballs were as wide as saucers, I couldn't urinate (friend was OK in that department), yet we didn't sweat and our heart rates weren't too far out of check. This lends further credibility to the idea our cerebellar and brain stem functions had gone awry. The inability to urinate was likely the cause of the increased BP as my kidneys became backed up with fluid. Edema/erythema followed as the kidneys began to fail. My friend checked me for CVA tenderness, for which I was positive. A long binge/OD on this stuff could possibly lead to stroke/heart attack/kidney failure. Long story short:
WATCH YOUR KIDNEYS and BODY TEMP ON THIS SHIT! STAY COOL, TRY TO URINATE, and DEFINITELY DO NOT DRIVE!
I believe these combinations are capable of producing serious side effects, and we will likely see some deaths/hospitalizations in the future as the chemicals become scheduled and testable. Several such events may have already occurred and misdiagnosed as MDPV intoxication. As a guideline, I would suggest careful and conscious observation of your body when clubbing or dancing excessively on this combo. Stay away from the party pills with unknown dosages/combinations of these two. Try lower dosages initially, if at all. Do NOT take this drug every weekend, month, or even every three months. This might be a 2x a year deal.
PS: Don't underestimate the potency of this combo. Any police officer would take your ass directly to jail if you were caught behind the wheel.