5HTP and MDMA / Ecstasy / MDA

[zdarlight420]

Hi -- Recently SWIM started taking 5HTP as a supplement, about 100mg to 200mg a day. SWIM would like to know is it safe to take 5HTP and MDMA at the same time / on the same days? SWIM has heard a few different things, such as taking 5HTP before MDMA can 'ruin' the experience. SWIM is also concerned that taking them at the same time might risk serotonin syndrome? If SWIM would like to continue taking 5HTP and MDMA, should SWIM not take 5HTP on the days SWIM takes MDMA? So stop taking 5HTP in the morning, take MDMA at night, take 5HTP the next day? Or would it be better to skip taking 5HTP up to one or two days before taking MDMA? Does anybody else have any experience with taking 5HTP and MDMA / XTC / MDA? Thank-you for the advice.

 

[terarc]

5-HTP and MDMA is potentially a risk for serotonin syndrome but I'm not sure how likely that is. It's advised to avoid 5-HTP 12 hours before and after dosing MDxx.

What is more certain though is that although 5-HTP may increase serotonin in the brain, it is actually downregulating your serotonin receptors... This means when you do take MDMA, the serotonin it releases is not gonna be felt by your receptors as much, you are effectively increasing your tolerance to MDMA in a way. As far as what is understood about it would suggest anyway, and plenty of anecdotal reports.

5-HTP is best used in the 3-5 days after MDMA use, 100mg before bed, as a simple 'safety net' to make sure you are getting more serotonin up there for your brain to replenish. There are likely more factors involved in MDMA induced depression / anxiety or neurotoxicity than serotonin depletion alone. It is no replacement for using tested MDMA, infrequently and responsibly, with a proper vitamin/antioxidant pre/post-load regimen.

It's also worth noting that it's unknown how well 5-HTP makes it to the brain, and 400mg of EGCG (green tea extract) taken with the 5-HTP might be needed to aid its ability to get there.

Unfortunately a lot of the science around serotonin/5-HTP/MDMA etc is not very solid...

 

[(((zen)))]

yeah man, i assure you it works after the MDMA. never used before the drop though. i take my first capsule of 5htp before i go to sleep right after the trip. definitely wake up better than non-5htp asissted hangover keep taking for like a couple of days... maybe a week. replenish the serotonin very quickly, you feel totally normal without a midweek blues whatsoever. perfect stuff