Some folks just are ‘hardheads’ to some extent. One knows of reliable reports of persons who prefer to dose in mid 40’s to mid 50’s with 4-AcO-MIPT. They reportedly have compounds that were lab analyzed and do not trip every weekend or anything like that.
One know of at least one case where an individual who was reportedly on no Rx medications, only dosed about 1X monthly or less, had known accurate material, took 26 mg. and got minimal effects (they said about equivalent to “1 hit” of street acid)… BUT here is the interesting piece… the effects, while mild, lasted a very long time for them. They have reported a similar effect with 4-HO-MIPT & 4-HO-DIPT as well. Namely that it was closer to 1.5 to 2.5X the duration most persons report but milder in level of intensity… People’s rate of absorption, metabolism, body chemistry, etc. can and do really vary.