EXTENSIONS AND COMMENTARY : This is a two-carbon homologue of psilocin, and as this latter chemical is orally active, it is not surprising that this is, as well. One direct comparison between the two materials, on widely separated days and at very high levels, indicated that 20 milligrams of 4-HO-MIPT was fully equivalent to 50 milligrams of psilocin in one report. And yet another report with 30 milligrams of the acetate ester, things were considerably more modest. At these higher levels, the onset was noted well within the first half hour.
Here, as with the 4-HO-DMT (psilocin) and the 4-HO-DET entries, some care must be made with the use of the term "acetate" or "phosphate." As these materials are both bases (tertiary amines) and acids (hydroxy indoles), they are in effect internal salts. For stability, they are usually converted into salts (at the amine end) or esters (at the phenolic end), or both. In this context, the term "acetate" can mean either modification, a salt or an ester involving acetic acid. And, of course, a phosphate can be either a salt or an ester. I will try to append the additional term "salt" or "ester" whenever this ambiguity is possible. In all of these studies, the acetate is the ester, and some of these are free bases, some are the hydrochloride salts and some are the fumarate salts.