• N&PD Moderators: Skorpio | thegreenhand

3-halo-4-(1,1-difluoromethoxy)-5-methoxyphenethylamine/cathinone/TMA homologs?

Difluoromescaline is known to be active in the rodent head-twitch assay and is significantly more potent than mescaline, I don't have the paper on this machine and cannot access the one that does have it currently, IIRC its somewhere in the region of being equipotent to 3C-P. It'll likely as not be tried, as would 4-difluoromethoxy-TMA should either the 3-brominated amphetamine prove a non-starter with regards to in-vivo activity or should any more of the aldehyde prove possible to obtain. Although the latter, would be difficult.

I think you are thinking of human assays. Trachsel is the one who made difluoromescaline and tested it and he doesn't run head twitch; he never cited any head twitch data in his comprehensive 2012 review. Can you find the paper you are referring to?
 
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