When I was sixteen and my friend was an idiot, before analogue laws and before most of the research chem sites had been shut down, he ordered some 5-MeO-AMT and mixed it with dextromethorphan hydrobromide multiple days in a row. As I understand, DXM inhibits an enzyme that breaks down serotonin and serotonin-like chemicals. My friend ended up going into a 3-week coma and asked me to ask the people on this forum what went wrong and if my hypothesis about the inhibited enzyme sounds most feasible or not? Thanks everyone, my buddy is ok now, after having to relearn how to walk, talk, shit, piss, everything. It also turns out he suffered from locked-in-syndrome. Crazy, right? I can't imagine being stuck in my body, paralyzed, and treated like I didn't even exist. Heh, turns out he could hear and understand everything that was going on around him once he woke up from his long nap. So, any psychiatrists here to share their opinion on what caused the coma? Besides my own idea, that is...thanks! If it helps, he had anoxic encephalitis.