Bioavailability/Half-life MEGA Thread

[enoughorangejuice?]

1. For the benzodiazepenes do not waste time plugging because it has no increase in bioavailability. Putting clonazepam among others under the tongue to dissolve and absorb may be a better alternative to swallowing.

2. Oxycodone works well when insufflated and it has more to do with how fast dopamine is released when snorting than the overall bioavailability. Filters in various oxy products play a big role as well. Plugging is a waste of time and Oxycontin should just be chewed.

3. For methylphenidate the nasal bioavailability is near 70%. This is often disputed because drug companies that design the drug and its analogues for children do not want to list a bioavailability for a dopamine re-uptake inhibitor that is stronger than cocaine aside from serotonin re-uptake.

4. To increase availability looking into enzymes is crucial for absorption. CYP-450 is of course crucial for many benzodiazepenes and opiates/opioids.

1. i've plugged xanax and valium and it makes them kick in MUCH quicker. within 2 minutes as opposed to 6-10 minutes when taken orally. i notice 10mg plugged valium is SLIGHTLY stronger than 10mg oral valium. IMEs that is.

2. plugging oxycodone IR , even oxycontin (brand name works best) is MUCH MUCH MUCH better than snorting oxy. much more is absorbed and you get higher and the duration lasts longer and you get much more of a rush plugging oxy than sniffing it IMEs. i just snorted 30mg roxicodone (ethex) and didn't get high. yesterday i plugged 10mg and felt waves of euphoria, etc. I'd bet that oxycodone has a higher rectal BA than oral or insuffilated.

3. ritalin/focalin is stronger than cocaine? per mg is what you mean? please post a link with a source that supports that statement.

4. For benzos the CYP3A4 is one the one you should focus on to extend duration of benzo highs and slow down the metabolization of them. Grapefruit juice and even star fruit (carambola) work on the CYP3A4 enzyme both of which potentiate benzos/opioids.

 

[bingey]

^
most sources give the rectal adminstration ba of morphine as equal to the oral but i think it's a lot higher more like 50% althought that's a totally subjective figure , i think their results has something to do with the fact that it's tested with morphine suppositories that contain a lot of wax and the like and wouldnt be as easily absorbed as morphine in water also i dont think they bother with making sure there is nothing in the end of the intestines like we druggies do

 

[acexnx316]

So the reason for snorting (benzo's for instance) is obviously to get a better rush/the drug to kick in quicker...

Now my question..

Can Clonazepam, Alprazolam, Lorazepam and/or Diazepam be snorted? And if so, I would assume it kicks in quicker and harder; if not, can they be plugged successfully with a quicker onset/rush compared to oral? And how long it takes to actually kick in is why I am asking, since most anything swallowed has to go through stomach, liver first pass/second pass, etc., etc. and there's no rush like there would be comparing to swallowing Oxycodone (No rush) or IV'ing (Or even plugging/snorting comparing to swallowing) Oxycodone crazy good rush.

I also have the Clonotril brand Clonazepam which is basically a lozenge designed to be used sublingually, but I would still be able to snort it yes? Only thing is, is there would be a TON of powder. Also, would these lozenges be effective by ROA (Route of Administration) of plugging?

And if I didn't already ask above, I do plug my Suboxone dose once or twice a day/every other day mixed with Diphenhydramine to potentiate the Buprenorphine, should I stick with swallowing/sublingual administration of my benzo's? Or is there a higher bioavailability and quicker onset/rush if I added it to the cocktail with my Suboxone and plug everything all at once? My last question is, are ALL benzos better to plug than swallow/sublingual ROA if I am looking for more of a quicker onset/rush and is there a difference at all in bioavailability of benzos between say, oral/sublingual ROA and plugging?

Any input and feedback/criticism is GREATLY appreciated and I thank you ALL in advance for your replies!

Take care and BE SAFE!

ONE.

 

[enoughorangejuice?]

whats the bioavailability of temazepam insuffilated, plugged, etc?

 

[johanneschimpo]

^ I doubt exact numbers exist for those two routes, since the pharm company probably wouldn't do research on those methods, since its meant for oral use only.

I did find that temazepam orally has 96% bioavailability, which is HUGE.




[Also, for ritalin/focalin being stronger than cocaine on a milligram per milligram basis... wouldn't your personal experience verify that? Of course, neither of us have had 100% pure cocaine, but it seems that ritalin is more potent per mg. 10mg ritalin = energy, amped up. 10mg cocaine = very little (can't tell you exactly because I've never done such a small amount)]

 

[enoughorangejuice?]

^do you think nasal temazepam is anywhere above 75% BA? is it worth it to sniff a temazepam? i have the 30mg capsules, and they remind me a lot of sonata (which only works if i sniff them). taken on a stomach with any food in it and it doesnt work (same with ambien, gotta sniff for them to work).

so i guess plugging isn't an option if oral is 96%... i wonder what nasal is...

 

[johanneschimpo]

^ Does it matter what nasal is? Its certainly not above 96%. Why do you want it up your nose so much? Its just going to be a waste.
If you're that into the concept, swallow the temazepam then snort a line of sugar or some BS and try to convince yourself that you snorted the pill.

 

[enoughorangejuice?]

^ rush, placebo affect rush.

have you eaten & sniffed ambien/sonata? theres a reason people sniff them.. the rush is intense...

 

[johanneschimpo]

^ The only things I'll put up my nose are powder heroin, cocaine, or ketamine and I haven't done any of them for well over a year. (some K right now would be soooo nice )
I don't enjoy the 'sensation' of inhaling shit up my nose. (Keep in mind thats just my feelings, I speak only for myself.)

 

[Mr Blonde]

^ No one likes the sensation, everyone just likes looking cool while they do it.

 

[bingey]

^ rush, placebo affect rush.

have you eaten & sniffed ambien/sonata? theres a reason people sniff them.. the rush is intense...

ambien/sonata is water soluble temazepam isn't , now there might be some absorption but i just dont see a rush happening

 

[jayslapmc]

my thoughts from personal experience

just my 2cents, from my own personal experiences, any contrary scientific journal articles with primary studies, ild love to read.

Ritalin...
snorted - quick high almost immediate onset, but very jittery and often causes me tremors. duration is about 2~3 hours

Plugging - water +syringe method - slow onset compared to snorting, but when it hits it HITS and i dont realise its impact until remedial tasks become not so remedial. Never noticed any jitters. duration approx 3~4 hours

oral - mild effects, honestly i only done it a couple times, compared to the plug or snort method, i have never looked back. i have never noticed any recreational value, mind you to get the same effects as snort or plug method, personally i think you need to have a quite substantially increased dose in comparison.

i do understand the whole placebo effect that may have contributing factors to my own personal experiences. but really i think that primary experiences are much more valuable then docked studies. i think that what this post misses most is the fact that each drug affects different people differently, as each and everyone is an individual. what works for some might not work for others, a good example of this is SSRI and SNRI's.

critical feedback welcome!

 

[Mr Blonde]

I disagree that primary experiences are 'much more important' then actual studies, seeing as apparently the placebo effect is alive and well in our resident benzo snorters. Besides, this thread is for actual numbers on bio-availability, not much we enjoyed a substance or a particular ROA.

 

[jayslapmc]

I disagree that primary experiences are 'much more important' then actual studies, seeing as apparently the placebo effect is alive and well in our resident benzo snorters. Besides, this thread is for actual numbers on bio-availability, not much we enjoyed a substance or a particular ROA.

True that, 100% snorting benzos is a waste due to metabolism of the compound. However i would just like to throw out there where do these bio availability statistics come from? who conducted these studies? perhaps the manufacturer of the drug?... being 100% serious i have no idea how these statistics came about, but i can imagine that there would be a valid source or published scientific journal stating these facts.... i guess long story short i would love to read these journals/reports by the author (not an authorship).

but i would just like to come to some common grounds... am i mistaken by saying that different drugs effect different people uniquely?

feel free to delete/move this post and discuss in pm if my posts are not suited for the manner that this thread is designed.

its a problem i have with myself for the need to justify everything

 

[Mr Blonde]

i guess long story short i would love to read these journals/reports by the author (not an authorship).

Uh, I really gotta go to bed but for starters check out PubMed, there are a lot of free full texts on there you can check out and it's a very useful source.

but i would just like to come to some common grounds... am i mistaken by saying that different drugs effect different people uniquely?

No, you are very much right in saying that. This thread is about bio-availability, right? I believe it's more useful to have statistics on the BA rather then how a user 'feels' a certain ROA affects them, due to the possibility of placebo effect giving distorted data. I can't give any examples right now but I have seen a few threads on here where people report great effects from using substances in a very wasteful way. Uh, one thing I can think of is smoking cocaine HCl.

feel free to delete/move this post and discuss in pm if my posts are not suited for the manner that this thread is designed.

its a problem i have with myself for the need to justify everything

No, that is perfectly OK and I understand completely. I have to go sleep now, have a good one.

 

[jayslapmc]

thanks for the pubmed referal, just having a quick flick through now. Kinda hard to find information about ROA especially for up the clacker in general. mind you i do appreciate the fact that there are many direct and indirect independent variables to consider in determining BA... thats alot of reading for me to do!

 

[FrostyMcFailure]

Why would so many people snort OCs, if the bioavailability its almost have that of oral, i think all those junkies would notice.

hhmmmm, you seeem pretty confident that every oxy addicts wearing their thinking cap.

 

[lost~triber]

im on 300 mgs day of ms contin and ionly absorb 20-30% WTF!!!

 

[enoughorangejuice?]

if temazepam isn't water soluable what if i mixed it with 1/2cc of vodka + 1/2cc of water and then plugged that...? would i get a rush?

 

[ScuvaJunt]

Report on Suboxone Insufllation Bioavlability

Saw some people looking for this, Hope this helps. you have to read it till the end to see the human statistic.


Karsten Lindhardt, Morten Bagger, Kasper Huus Andreasen and Erik BechgaardCorresponding Author Contact Information, E-mail The Corresponding Author
Department of Pharmaceutics, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark

Received 4 October 2000;
revised 18 January 2001;
accepted 24 January 2001
Available online 30 March 2001.

Purchase the full-text article



References and further reading may be available for this article. To view references and further reading you must purchase this article.

Abstract

The purpose of the present study of buprenorphine is to add information about the correlation between various animal models and nasal bioavailabilities in man. PEG 300 was added to one formulation to study whether the addition of the co-solvent results in the same absorption pattern as seen for sheep. The bioavailability of intranasal buprenorphine 0.6 mg in PEG 300 and 5% dextrose was assessed in a cross-over study in six rabbits. The mean bioavailabilities, Tmax and Cmax were 46% (S.D. ±13) and 53% (S.D. ±17), 8 and 12 min, 28 and 27 ng/ml for 30% PEG 300 and 5% dextrose, respectively. No significant differences were found between the nasal buprenorphine formulations. The bioavailabilities in rabbit and sheep, respectively, were ≈2.5 and four times higher than for man. The absorption rate was faster for rabbit and sheep than for man. It appears that rabbit and sheep bioavailability differ from humans, especially with respect to rate. PEG 300 do not increase the bioavailability of buprenorphine.