I’d like this thread to serve as a place to discuss the nuances of MDMA’s pharmacology.
First I was wondering why oral MDMA has more love to it then other ROA’s and found this article.
This shows the metabolites HMMA and others have a significant hormone impact (including oxytocin the love hormone) compared to MDMA alone. These metabolites form more with oral administration.
Next, I’ve always wondered why product that smelled of safrole felt better than not. This may be why?..
It sounds like safrole may be a decent enzyme inhibitor.
Edit in more later.
-GC
First I was wondering why oral MDMA has more love to it then other ROA’s and found this article.
This shows the metabolites HMMA and others have a significant hormone impact (including oxytocin the love hormone) compared to MDMA alone. These metabolites form more with oral administration.
Next, I’ve always wondered why product that smelled of safrole felt better than not. This may be why?..
Inhibition of human cytochrome P450 enzymes by the natural hepatotoxin safrole
The hepatotoxin, safrole is a methylenedioxy phenyl compound, found in sassafras oil and certain other essential oils. Recombinant cytochrome P450 (CY…
www.sciencedirect.com
It sounds like safrole may be a decent enzyme inhibitor.
Edit in more later.
-GC