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Misc Little known recreational pharmacuticals

Ignio said:
Potentiating benzo's with Promathezine. What wuld 100 mg diazepam before now requires 3 x 25 Promathezine and 50 mg diazepam.
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I used to do this alot, works wonders. Promethazine is so easy to source and cheap in the UK too
 
Wilson Wilson said:
Yep this was a big thing in Scotland. Nitrazepam ("Moggies") was big too but I don't think many people were shooting it up. I've been able to get ahold of nitrazepam only twice, both times proper boxed UK pharma, and it really does knock you sideways that one does. Very different from the soft comfortable feeling of temazepam. Nitrazepam just smashes ya.

Oh zopiclone is probably a little known one to you Yanks as well since it's another one not scripted in the US. Pretty standard z-drug stuff but feels good with weed.
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Temazepam used to come in liquid gel shaped footballs.ppl used to shoot "footies" but there were heaps of ppl having problems with doing it like needing surgery or hand amputation bcoz the wax in them clogged Ur veins.ppl still injected them knowing this.
Now we only have temazepam pills.
 
devilsgospel said:
I thought we did get zopiclone over here? Or am I thinking of zolpidem?
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You're probably thinking of zolpidem (Ambien).

"In the United States, zopiclone is not commercially available, although its active stereoisomer, eszopiclone is."

en.wikipedia.org

Zopiclone - Wikipedia

en.wikipedia.org en.wikipedia.org

Not sure what the subjective differences are between zopiclone and eszopiclone are though, never tried the latter.
 
Cloxazolam.. now it is only marketed in a few countries, belgium, japan and argentina i guess. Very nice benzo, the best one to me
 
O-DSMT is actually on track to becoming an official pharmaceutical! For those that don’t know, it’s currently a “research chemical”, it’s what Tramadol metabolizes into and causes the opioid effects, so the safety profile is already known.

Of course the pharmaceutical companies saw the potential money in this, and are now working to have O-DSMT an official branded medication. Which I’m glad for, as it will reduce some of the odd side effects of regular Tramadol, but I’m also sad because it’s extremely affordable and a GREAT tool for tapering off opioids, or just sustaining a habit if you desire.

Will find and edit in more info!
 
Helpmeescapethis said:
Of course the pharmaceutical companies saw the potential money in this, and are now working to have O-DSMT an official branded medication. Which I’m glad for, as it will reduce some of the odd side effects of regular Tramadol, but I’m also sad because it’s extremely affordable and a GREAT tool for tapering off opioids, or just sustaining a habit if you desire.
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If a pharmaceutical company patents the use of O-DSMT for a particular indication, that won't affect the fact that the composition-of-matter patent has long expired, so laboratory chemical vendors, for example, would still be allowed to sell it.
 
S.J.B. said:
If a pharmaceutical company patents the use of O-DSMT for a particular indication, that won't affect the fact that the composition-of-matter patent has long expired, so laboratory chemical vendors, for example, would still be allowed to sell it.
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There is no patent on it, hence it being an RC.
 
Fun fact: lots of the drugs we think of as "research chemicals" are actually compounds that were patented years ago and have been "rediscovered" as drugs of abuse.

U-44700, AH-7921, most of the new cannabinoids, diphenidine and its relatives, RC benzos like pyrazolam, etc. - all of those were patented at one point in time.
 
Wilson Wilson said:
Oh zopiclone is probably a little known one to you Yanks as well since it's another one not scripted in the US. Pretty standard z-drug stuff but feels good with weed.
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We have s-zopiclone (eszopiclone, I guess they think removing the dash and spelling out the "es" makes it sound better or something, I don't get it), it's branded as Lunesta. And of course, zolpidem (Ambien).

True story, I once went in to my college's doctor services, trying to seek drugs. I told him I had a bad cough and that DXM made me feel awful. He had all this pharma advertising up on the walls about Ambien. So I was like, hmm, good idea, perhaps I also have trouble sleeping?? I asked him about it and he was like (and I quote) "bro, ambien is for little old ladies who can't sleep. Are you a little old lady, bro?" Of course I said no... but he did script me a bottle of DAT LEAN (codeine/promethazine). I was ecstatic. Went home, figured I was in for a treat. Took twice the prescribed dose... got sleepy as fuck, passed out.

Moral of the story? Don't believe rap videos. Lean aint shit, makes you lean so far over you're horizontal, and sleeping. Tried to catch a good high off of that bottle a few times, nope, never happened. Taking a couple of tylenol 3s was much better,
 
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sekio said:
RC benzos like pyrazolam, etc. - all of those were patented at one point in time.
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Indeed, most of those RC benzos are ripped straight from 60's Roche papers. Only a few of them are truly novel such as flubromazolam.

4-MMC is also another RC that was rediscovered. Same story for most RCs.

Xorkoth said:
We have s-zopiclone (eszopiclone, I guess they think removing the dash and spelling out the "es" makes it sound better or something, I don't get it), it's branded as Lunesta. And of course, zolpidem (Ambien).

True story, I once went in to my college's doctor services, trying to seek drugs. I told him I had a bad cough and that DXM made me feel awful. He had all this pharma advertising up on the walls about Ambien. So I was like, hmm, good idea, perhaps I also have trouble sleeping?? I asked him about it and he was like (and I quote) "bro, ambien is for little old ladies who can't sleep. Are you a little old lady, bro?" Of course I said no... but he did script me a bottle of DAT LEAN (codeine/promethazine). I was ecstatic. Went home, figured I was in for a treat. Took twice the prescribed dose... got sleepy as fuck, passed out.

Moral of the story? Don't believe rap videos. Lean aint shit, makes you lean so far over you're horizontal, and sleeping. Tried to catch a good high off of that bottle a few times, nope, never happened. Taking a couple of tylenol 3s was much better,
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I'm curious if the s-isomer of zopiclone is the same thing but more potent or if there's a subjective difference in effects, like how Adderall and Dexedrine feel different. I've never compared the two so have no idea personally.

"Lean" is indeed very overhyped. In the UK we can straight up buy codeine and promethazine (separately) OTC. The promethazine just makes me tired and kills off the nice subtle codeine buzz. I far prefer straight codeine. Or ya know, a proper opiate ;)
 
Promethazine puts me to sleep too. Tried lean once and was like...yo just give me some morphine man this shit is a sleep aid. Codeine/morphine shouldn't be messed with like that (ya know unless you actually need it for real medical reasons...not degenerate reasons like uh, me).
 
Chloral hydrate is not a complicated synthesis, it';s just comparatively hazardous and time consuming. As I understand it, you bubble pure chlorine gas into ethyl alcohol (grain alcohol) for quite extended times first at ice cold temperatures and gradually raising to around 90-100 degrees C where the chloral begins to reflux. The reaction is considered complete when the liquid no longer absorbs any chlorine. I have heard tell that it's an all-day affair as the chlorination is quite slow... also, the yields are not 100% (are they ever?) so distillation of the chloral is a requirement, before it is mixed with a measured amount of water to form the hydrate.

So, not exactly a process that would be terribly safe to run at home. Just say it out loud to yourself: boiling a solution of high proof alcohol while adding pure chlorine gas to it. It really doesn't seem terribly safe... you'd need a good fume hood and a scrubber for the extra chlorine gas, a distillation setup, etc. - it's a huge hassle.

For some crazy reason chloral hydrate is actually still used as a hypnotic. I can't imagine any modern doctor would prescribe it, but seeing as it's both cheap, effective, and fairly proven in terms of acute safety (though you CAN overdose on it quite easily and it's considered to be hepatotoxic) I suspect it remains useful in some edge cases.
 
^Edge cases? Not being rude just wondering if there is anything more to explain about that.

I want to know the mechanism that has it causing a dependency (and absent of prior dependency or addiction to a GABAergic) after two weeks of daily use. For benzos, and I'm assuming barbs, it takes twice as long to get dependent on.
 
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