Methylphenidate VS Amphetamine

[JohnBoy2000]

I know amphetamine is basically the "gold standard" of recreational stimulant use.

However, methylphenidate crops up there with reasonable regularity also.

Mechanism - ritalin being an NDRI.
Adderall being a transporter reverser, if I have that correct?

Outcome?

One being more potent presumably?

Basically my question being, my response to ritalin was stimulation, but ultimately a stimulation which wasn't desirable.

Apart from mechanism - are there any other significant differences between the two, like brain areas they're affecting?
That would yield a significantly varied "psychoactive" response, if that makes sense?

 

[TripSitterNZ]

I did alot of methylphendiate imo its inferior to things like vvyanse its a different kind of stimulation a unique amphetamine feels way cleaner and makes you feel like you can achieve anything. Methylphendiate made me very antisocial and alot of anxiety

 

[KS78]

I use it regularly because I get it legally prescribed and it's a hassle for me to deal with dealers because I don't have the patience anymore to deal with their never ending bullshit. It's hard to find good connections for speed and meth in Istanbul.
I definitely agree with Tripsitter on it causes unnecessary anxiety which also makes you antisocial. I would pick speed and meth over it any day if I still had the patience or the will to deal with the sellers whom I would like to shoot from the knee for the way they do business.
I have to add that it has a wonderful synergy with opium though.

 

[ChemicallyEnhanced]

Amphetamine is my fav stim.
I do love Methylphenidate but it's way too short acting for me. I did take it either snorting or sublingually but it seemed to last only about 15 mins.

 

[TripSitterNZ]

Amphetamine is my fav stim.
I do love Methylphenidate but it's way too short acting for me. I did take it either snorting or sublingually but it seemed to last only about 15 mins.

thats the wrong way to do methylphedinate. Concerta long release 54 mg would have me fucking wired out of my mind for 24+ hours before i could sleep

 

[ChemicallyEnhanced]

thats the wrong way to do methylphedinate. Concerta long release 54 mg would have me fucking wired out of my mind for 24+ hours before i could sleep

Ah maybe that's why then. It was just 10mg instant release Ritalin I had.

 

[GENGAR]

Adderall is better

 

[JohnBoy2000]

The mechanisms of both would be considered reasonably similar?

Same transmitters implicated.
Synaptic cleft levels of transmitter are basically bumped in similar fashion in similar brain areas?
Amphetamine doing this more violently but, ultimately a similar outcome?


The difference between pharma grade amphetamine and "speed" based amphetamine, powder etc?

Therapeutic window is shorter for the latter I assume?

Anyone comment on this?

 

[JohnBoy2000]

I use it regularly because I get it legally prescribed and it's a hassle for me to deal with dealers because I don't have the patience anymore to deal with their never ending bullshit. It's hard to find good connections for speed and meth in Istanbul.
I definitely agree with Tripsitter on it causes unnecessary anxiety which also makes you antisocial. I would pick speed and meth over it any day if I still had the patience or the will to deal with the sellers whom I would like to shoot from the knee for the way they do business.
I have to add that it has a wonderful synergy with opium though.

Can you substitute your legal prescription of adderall with "speed", amphetamine powder that's used recreationally?

 

[CFC]

Their mechanisms aren't the same, no. Which is why they feel quite subjectively different to users.

This paper comparing the mechanisms is open access:

The pharmacology of amphetamine and methylphenidate: Relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities - PubMed

Psychostimulants, including amphetamines and methylphenidate, are first-line pharmacotherapies for individuals with attention-deficit/hyperactivity disorder (ADHD). This review aims to educate physicians regarding differences in pharmacology and mechanisms of action between amphetamine and...

www.ncbi.nlm.nih.gov

Abstract
Psychostimulants, including amphetamines and methylphenidate, are first-line pharmacotherapies for individuals with attention-deficit/hyperactivity disorder (ADHD). This review aims to educate physicians regarding differences in pharmacology and mechanisms of action between amphetamine and methylphenidate, thus enhancing physician understanding of psychostimulants and their use in managing individuals with ADHD who may have comorbid psychiatric conditions. A systematic literature review of PubMed was conducted in April 2017, focusing on cellular- and brain system-level effects of amphetamine and methylphenidate. The primary pharmacologic effect of both amphetamine and methylphenidate is to increase central dopamine and norepinephrine activity, which impacts executive and attentional function. Amphetamine actions include dopamine and norepinephrine transporter inhibition, vesicular monoamine transporter 2 (VMAT-2) inhibition, and monoamine oxidase activity inhibition. Methylphenidate actions include dopamine and norepinephrine transporter inhibition, agonist activity at the serotonin type 1A receptor, and redistribution of the VMAT-2. There is also evidence for interactions with glutamate and opioid systems. Clinical implications of these actions in individuals with ADHD with comorbid depression, anxiety, substance use disorder, and sleep disturbances are discussed.

 

[KS78]

I don't have a prescription for Adderall, they don't prescribe Adderall here. The closest you can get to amphetamines is Ritalin.

 

[JohnBoy2000]

I use it regularly because I get it legally prescribed and it's a hassle for me to deal with dealers because I don't have the patience anymore to deal with their never ending bullshit. It's hard to find good connections for speed and meth in Istanbul.
I definitely agree with Tripsitter on it causes unnecessary anxiety which also makes you antisocial. I would pick speed and meth over it any day if I still had the patience or the will to deal with the sellers whom I would like to shoot from the knee for the way they do business.
I have to add that it has a wonderful synergy with opium though.

I don't have a prescription for Adderall, they don't prescribe Adderall here. The closest you can get to amphetamines is Ritalin.

So your prescription is for Ritalin?


Main thing I want to know at this stage is, if adderall is comprised of "amphetamine" salt - is there any difference between taking it, and the equivalent dose of recreational "speed" (amphetamine?).

I don't know the regular dose of speed, but I believe therapeutic doses are 5 to 60 mg?

So, 5 to 60 mg of "speed", is equivalent to a capsule of the denominated dose of adderall/dexedrine? (apart from the price)

 

[JohnBoy2000]

Just gonna add this link also:

Amphetamine

Amphetamine (also known as alpha-methylphenethylamine, amfetamine, speed, or by brand names including Adderall, Dexedrine and Tentin) is a classical stimulant substance of the phenethylamine class. It is the parent compound of the substituted amphetamines, a diverse group that includes...

psychonautwiki.org

The recreational doses are pretty much exactly the therapeutic guideline doses.

I gotta ask - given the cost difference, doesn't that basically mean that big-pharma are violating the common man with a genuine health condition?

 

[AlphaMethylPhenyl]

When we say "gold standard", its about medications being effective for therapy, not as euphoriants.

Adderall has a very complex mechanism. Ritalin is much more straightforward. But they end up having a similar overall effect.

Potency can be found with a fast google search..

Addicts take upwards of several hundred mg's at a time. But new users may find mood effects with a relative microcosm of that, like 10mg.

Big pharma isn't concerned with violating the common man, as you say. They have that bottom line of finances.

In some rare cases stimulants are, again sparsely, tried with other antidepressants. The mood effects fade, though, and people don't recognize that this is how it will be. Then they try to persuade their doctor to give them ever higher doses. The positive effects fade with time, but not the negative side effects. Those latter ones go up and stay their as long as one is at a particular dose. Staying at a lower dose, if one is to at all take it, is best.

In fact wikipedia has a pretty good rendition of how amphetamine works.

 

[GENGAR]

Really never had Ritalin before

 

[TripSitterNZ]

vvyanse is the purest form of amphetamine you can get. It converts into 100% d-apheta in the body

 

[Cream Gravy?]

vvyanse is the purest form of amphetamine you can get. It converts into 100% d-apheta in the body

That may be so but it's shit for recreation. Lasts too long and doesn't hit as hard.

 

[AlphaMethylPhenyl]

That would depend on tolerance, both natural and otherwise.

 

[sekio]

vvyanse is the purest form of amphetamine you can get.

vyvanase is a prodrug for amphetamine, if you want pure d-amp just get dexedrine like a big boy

 

[CoastTwoCoast]

When we say "gold standard", its about medications being effective for therapy, not as euphoriants.

Adderall has a very complex mechanism. Ritalin is much more straightforward. But they end up having a similar overall effect.

Potency can be found with a fast google search..

Addicts take upwards of several hundred mg's at a time. But new users may find mood effects with a relative microcosm of that, like 10mg.

Big pharma isn't concerned with violating the common man, as you say. They have that bottom line of finances.

In some rare cases stimulants are, again sparsely, tried with other antidepressants. The mood effects fade, though, and people don't recognize that this is how it will be. Then they try to persuade their doctor to give them ever higher doses. The positive effects fade with time, but not the negative side effects. Those latter ones go up and stay their as long as one is at a particular dose. Staying at a lower dose, if one is to at all take it, is best.

In fact wikipedia has a pretty good rendition of how amphetamine works.

You're right that in the end you will end up raising your doses with either Adderall or Methylphenidate, especially addicts. Just can't help it.

Amphetamines have way more euphoria. That's why I was too out of control and quit, you just want to ride that euphoria all day. It turns into psychosis and possibly death. I hate amphetamines. I feel it's way more toxic than methylphenidate, that's just me.

At least when I go for days without Concerta, I can still get out of bed and function. When I was on Adderall and went without it, I couldn't get out of bed at all. I didn't want to do anything without it. It's like it left me lifeless. I can go without Concerta with no problem. When I'm back on it, it's fine. That's why I prefer Concerta. If you don't have Gabapentin or kratom to take the edge off of Ritalin or Concerta, you'll feel like a crackhead. lol

I just got Intuniv, it's supposed to help with the stimulant crash. I was prescribed 1 mg. I'll see how it works with my Concerta when I get it Monday.