Hello,
recently CFC told about the usage of the Losartan (angiotensin II type 1 receptor (AT1) antagonists) in steroid cycles due to its beneficial effects:
- anti-fibrotic effect
- reduced risk of heart hypertrophy
- reduced risk of high blood pressure
- few negative sides
Heare are some studies.
My current opinion is using 25mg Losartan ed on heavy cycles >1g of steroids with more than one compound while controlling blood pressure that it does not get to low.
- What do you think and what is your experience?
- Would you suggest using it only on heavy cycles >1g of steroids with more than one compound (test, deca/tren/anadrol) or also on low dose (500mg test) and single-compund cycles (1000mg test).
- What would be the recommended starting dosage and intake protocol even if your blood pressure is in range? It may be harmful to reduce it to much.
- Do you think there could be a general health benefit of taking low-dose Losartan (maybe like low dose of aspirin) regardless of taking AAS?
Thanks.
recently CFC told about the usage of the Losartan (angiotensin II type 1 receptor (AT1) antagonists) in steroid cycles due to its beneficial effects:
- anti-fibrotic effect
- reduced risk of heart hypertrophy
- reduced risk of high blood pressure
- few negative sides
Heare are some studies.
Chronic, supra‐physiological doses of nandrolone decanoate and exercise induced cardio‐toxicity in an animal‐model study
This study shows, unequivocally, that the blockade of the renin‐angiotensin system (RAS), and particularly of angiotensin II type 1 receptor (AT1R) by losartan, prevents QT prolongation and that the administration of chronic, supraphysiological doses of ND induces parasympathetic autonomic dysfunction.
https://onlinelibrary.wiley.com/doi/full/10.1111/apha.12093
Anabolic steroids induce cardiac renin-angiotensin system and impair the beneficial effects of aerobic training in rats
CVF and LV hypertrophy were prevented by losartan treatment
https://www.physiology.org/doi/full/10.1152/ajpheart.01251.2006
Anabolic steroid associated to physical training induces deleterious cardiac effects.
Both losartan and spironolactone inhibited the increase of CVF and collagen type III. In addition, both treatments inhibited the increase in left ventricle-angiotensin-converting enzyme I activity, CYP11B2, 11β-HSD2, TGFβ, and osteopontin induced by the ND treatment.https://europepmc.org/abstract/med/21407130
AT1 and Aldosterone Receptors Blockade Prevents the Chronic Effect of Nandrolone on the Exercise-Induced Cardioprotection in Perfused rat Heart Subjected to Ischemia and Reperfusion
The nandrolone-induced changes of AT1-R, MR, and KATP subunits expression was normalized by the losartan and spironolactone treatments.https://link.springer.com/article/10.1007/s10557-013-6503-8
Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291109/
My current opinion is using 25mg Losartan ed on heavy cycles >1g of steroids with more than one compound while controlling blood pressure that it does not get to low.
- What do you think and what is your experience?
- Would you suggest using it only on heavy cycles >1g of steroids with more than one compound (test, deca/tren/anadrol) or also on low dose (500mg test) and single-compund cycles (1000mg test).
- What would be the recommended starting dosage and intake protocol even if your blood pressure is in range? It may be harmful to reduce it to much.
- Do you think there could be a general health benefit of taking low-dose Losartan (maybe like low dose of aspirin) regardless of taking AAS?
Thanks.
Last edited: