I find loperamide to be good for RLS, but not for depression. It makes my body feel very heavy.
It does have a substantial effect on the body in high dosages, I don't care what anyone says to the contrary unless they've tried it themselves (it doesn't seem to work for some people). But it's no magic bullet. It definitely won't 100% cure withdrawal no matter what the dose. It does not produce any sort of euphoria. It does produce a body presence that helps with withdrawal symptoms. It takes away some of the anxiety, and the runny eyes/nose, and the RLS (for me). Removal of RLS is like 50% of withdrawal for me, definitely the worst symptom. It makes it a lot more bearable but it's not going to cure your withdrawals, it just takes like 75% of it away (but does leave the depression in my experience, but mutes it some as well). Also it's dangerous and bad for your heart.