Even if it works (like you feel, don't feel something.) sometimes, it doesn't have to work always or at all. The science behind it is not well understood, and there are only speculations. I didn't mention this b/c you brought some scientific facts, only for the sake of completeness, and to point out there is little of what we know for sure on that subject.
The fact you don't feel something, or you feel it, doesn't mean something doesn't have impact on you body, or that it has it. When you take opioids, opiates, you can hardly feel any other drug. Not even alcohol. Not weed. But that doesn't mean it 'reversed' their effect! I know a guy who overdosed like that. He took a usual dose of Tramadol, and he than continued to smoke weed, joint after joint. That was it.
Same happens with alcohol. Drinking alc on heroin, morphine, tramadol etc. doesn't do a shit (You cannot feel the effect of ethanol, until you take a sick amount of it.), except it increases the chance of side effects significantly, and provokes OD and death.
So no, it is not a plus, minus logic.