Nootropics The Big & Dandy Nootropics Thread (Stack 2)

[Solipsis]

I can agree with that in terms of loading up on anti-oxidants all day every day as panacea is bullshit, but in the context of heavy stimulant use I suppose an attack dose of anti-oxidants to limit oxidative stress as much as you can could indeed help without you having to worry about free radical depletion or something like that.
Chronic excess of anti-oxidants floating around is probably a bad idea apparently for the reason that they will unselectively kill off the useful endogenous oxidative compounds... but targeted use seems to have something to it from where I am standing. Not sure that perspective is taken into account in these articles.
I also think it matters if you use a variety of exotic anti-oxidants or just take a megadose of vitamin C to support (not magically create but at least support) a healthy immune system and resistance.

Unfortunately I am not an expert on anti-oxidants, I know about ALA (alpha lipoic acid) having been presented in the past as a healthy supplement. Also ECGCs are anti-oxidants if I am not mistaken. I have green tea extract myself and from what I know about green tea is that there seem to be mostly positive things associated with drinking a lot of it.

 

[Cyanoide]

I've never had any need or interest in nootropics before but got a sample of Noopept so I thought I as well might give it a try. I've just gone through SSRI withdrawal and feel a bit lethargic and unmotivated, so it'll be interesting to see what it does. I'll start with 30 mg/day.

 

[JackiesBabyy]

Wow, St. John's Wort really does work for depression.

I've had atypical depression for years(hypersomnia from hell: I could sleep 15 hours and still be look like a guy who's chronically sleep deprived, depressed mood most of the time, rejection sensitivity to the extreme, and no motivation) I've tried two SSRIs and they didn't work, and I didn't want to lose my ability to have an orgasm, so for a while I just kind of dealt with it.

About a month ago, I went to a psychiatrist for help with my ADHD, he put me on adderall XR in the morning and an IR in the afternoon. (I've only used it recreationally once so far, going to try to keep that to less than once a month because of how much it helps with my ADHD, I don't need to build a super-tolerance). This helped the depression somewhat, mainly the rejection sensitivity and hypersomnia, but I'd be back to normal once it wore off.

I asked what my options were for antidepressants that didn't cause sexual dysfunction, and he said Wellbutrin is the only one. Problem is, I'm a smoker and I have no desire to quit smoking and wellbutrin would kind of force that by making cigarettes taste horrible. The other alternative was St John's wort, which I believed was a load of crap like most herbal supplements. But upon looking it up, it turns out there is scientific backing that it works for people and it isn't a homeopathic load of crap. I picked up a bottle last week and started taking it 3x per day as directed.

Wow, the next day after getting it, it was clear that it worked. The adderall felt the same as always, and when it wore off, I just felt normal. Not happy or euphoric, just no longer depressed and tired when not on adderall. I've been sleeping 7 hours and feeling fine, and I can easily take a tolerance day off of adderall without feeling like an immobile lump of crap.

I don't know if it's the combination of the two that's helped so much or if it's just the SJW, but the last time I remember feeling like this was at around 14-15, before the depression started.

Remember though, YMMV. I only had depression without anxiety (well, without an unhealthy level of anxiety), so, I can't say if it works for that too. And according to google, SJW+adderall can cause blood pressure to uncomfortably raise for some people. I haven't gotten or noticed this, but that's probably because my blood pressure is low normally (100/60). But I'd still recommend trying this before any SSRIs, all they did was give me side effects with no help.

 

[PeacePipeChief]

SJW is OTC isnt it ? do u just ask for saint johns wart pills ? cause ive been getting seriously depressed and if the doctors not gonna help id like to know there is a back up .

 

[JackiesBabyy]

SJW is OTC isnt it ? do u just ask for saint johns wart pills ? cause ive been getting seriously depressed and if the doctors not gonna help id like to know there is a back up .

Go to any walgreens/cvs/rite aid type store will carry them.(Look by the vitamins, 5-htp and other herbal stuff) The brand I use is Nature's Bounty. Since it's herbal other brands might work different. Also, do you have atypical depression or melancholic depression? I've heard it works better for my type (the former)

If that doesn't work and you aren't afraid of ED/side effects/dietary restrictions, ask for Nardil. They don't like to prescribe it because of the dietary restrictions, but since it's not abusable, if you convince them you've done enough research and know the risks they'll give it to you. Two of my friends are on it, said it cured their depression/anxiety completely when SSRIs failed.

 

[Swimmingdancer]

I asked what my options were for antidepressants that didn't cause sexual dysfunction, and he said Wellbutrin is the only one. Problem is, I'm a smoker and I have no desire to quit smoking and wellbutrin would kind of force that by making cigarettes taste horrible. The other alternative was St John's wort, which I believed was a load of crap like most herbal supplements. But upon looking it up, it turns out there is scientific backing that it works for people and it isn't a homeopathic load of crap. I picked up a bottle last week and started taking it 3x per day as directed.

Wow, the next day after getting it, it was clear that it worked. The adderall felt the same as always, and when it wore off, I just felt normal. Not happy or euphoric, just no longer depressed and tired when not on adderall. I've been sleeping 7 hours and feeling fine, and I can easily take a tolerance day off of adderall without feeling like an immobile lump of crap.

Wow, that's awesome that St John's Wort has been so helpful for you. I have tried nearly every other supplement but haven't bothered with SJW yet because, like you, I'd assumed that the effects would be nothing or subtle at best. Maybe I'll try it

Just wanted to point out though that Wellbutrin (bupropion) doesn't make cigarettes taste terrible or force you to quit smoking. All it does is somewhat reduce cravings for cigarettes. I have a friend who is on Wellbutrin who smokes and all it did for him was make him not feel the need to smoke as much and he mainly smokes only when he wants to now (about 8-10 cigarettes a day instead of 20). It does not make the cigarettes taste any different. Some people might find that they don't get as much of a "high" (if you want to call it that) from cigarettes when they do smoke. My friend also says Wellbutrin is the best anti-depressant he has ever tried and he does not experience any side-effects from it.

One note about Saint Johns Wort for anyone interested in trying it is that it does have a number of drug contraindications, so if you are taking any prescription meds talk to your doctor before taking it. If you take other drugs or supplements, do some thorough research before taking SJW.

 

[JackiesBabyy]

Wow, that's awesome that St John's Wort has been so helpful for you. I have tried nearly every other supplement but haven't bothered with SJW yet because, like you, I'd assumed that the effects would be nothing or subtle at best. Maybe I'll try it

Just wanted to point out though that Wellbutrin (bupropion) doesn't make cigarettes taste terrible or force you to quit smoking. All it does is somewhat reduce cravings for cigarettes. I have a friend who is on Wellbutrin who smokes and all it did for him was make him not feel the need to smoke as much and he mainly smokes only when he wants to now (about 8-10 cigarettes a day instead of 20). It does not make the cigarettes taste any different. Some people might find that they don't get as much of a "high" (if you want to call it that) from cigarettes when they do smoke. My friend also says Wellbutrin is the best anti-depressant he has ever tried and he does not experience any side-effects from it.

One note about Saint Johns Wort for anyone interested in trying it is that it does have a number of drug contraindications, so if you are taking any prescription meds talk to your doctor before taking it. If you take other drugs or supplements, do some thorough research before taking SJW.

The only time I feel any kind of buzz from a cigarette is when I haven't smoked in over a day, which is incredibly rare because I'm a pack-a-day smoker. But yeah, some sources say that it works because hypericin (chemical in SJW) is a minor MAOI, and treatment-resistant depression is treated with a powerful MAOI (nardil) and a low dose of adderall, so that probably helps too. (I know they say don't take amps with MAOIs, but they mean prescription MAOIs with regular doses of adderall. Amphetamine is a very weak MAOI itself.).

 

[Swimmingdancer]

The only time I feel any kind of buzz from a cigarette is when I haven't smoked in over a day, which is incredibly rare because I'm a pack-a-day smoker. But yeah, some sources say that it works because hypericin (chemical in SJW) is a minor MAOI, and treatment-resistant depression is treated with a powerful MAOI (nardil) and a low dose of adderall, so that probably helps too. (I know they say don't take amps with MAOIs, but they mean prescription MAOIs with regular doses of adderall. Amphetamine is a very weak MAOI itself.).

I have "atypical treatment resistant" depression too, and ADD, and I found Adderall IR somewhat helpful, but here in Canada you can only get the XR, which I did not find helpful, so I stopped taking it. I'm also trying not to be on any prescription meds long-term, for a number of reasons. Will give the SJW a try though. Thanks for sharing your experience with it.

 

[JackiesBabyy]

I have "atypical treatment resistant" depression too, and ADD, and I found Adderall IR somewhat helpful, but here in Canada you can only get the XR, which I did not find helpful, so I stopped taking it. I'm also trying not to be on any prescription meds long-term, for a number of reasons. Will give the SJW a try though. Thanks for sharing your experience with it.

You can turn a 30mg XR in to two doses of 15mg IR by crushing the beads and splitting the powder in half.

 

[Swimmingdancer]

You can turn a 30mg XR in to two doses of 15mg IR by crushing the beads and splitting the powder in half.

Thanks for the tip. I only have a couple capsules left as I didn't bother getting a new prescription, but if I decide to give Adderall another try in the future maybe I will try that.

 

[Tripman]

I'm moving this to PD as they cover nootropics.

 

[Survived Abortion]

I asked what my options were for antidepressants that didn't cause sexual dysfunction, and he said Wellbutrin is the only one. Problem is, I'm a smoker and I have no desire to quit smoking and wellbutrin would kind of force that by making cigarettes taste horrible.

The only time I feel any kind of buzz from a cigarette is when I haven't smoked in over a day, which is incredibly rare because I'm a pack-a-day smoker.

There's your problem. Stop smoking and get some exercise. Seriously, you smoke a pack of ciggarettes a day, and you wonder why you're not getting any better? Try detoxifying your body of all the crap that's keeping you burdened down with negative shit going back years, then you'll start to feel better. As long as you continue to pile on the poisonous garbage such as ciggarette smoke and other bad habits, your body will never have a chance to heal. And thus your mind/psyche won't heal. Your body is your mind.

Why would you even want to protect your addiction to ciggarettes anyway? Bloody hell, any chance to get off of them should be welcomed with open arms, but I guess some people really are naive enough to think that self-destruction is the route to happiness.

Anyhow, this is hardly PD material, so I'll leave it up to the mods to decide what to do with it.

 

[JackiesBabyy]

There's your problem. Stop smoking and get some exercise. Seriously, you smoke a pack of ciggarettes a day, and you wonder why you're not getting any better? Try detoxifying your body of all the crap that's keeping you burdened down with negative shit going back years, then you'll start to feel better. As long as you continue to pile on the poisonous garbage such as ciggarette smoke and other bad habits, your body will never have a chance to heal. And thus your mind/psyche won't heal. Your body is your mind.

Why would you even want to protect your addiction to ciggarettes anyway? Bloody hell, any chance to get off of them should be welcomed with open arms, but I guess some people really are naive enough to think that self-destruction is the route to happiness.

Anyhow, this is hardly PD material, so I'll leave it up to the mods to decide what to do with it.

I still enjoy smoking very much. Why would I quit doing something that I enjoy, even if it has bad health effects? I enjoy drinking pepsi. It's been well established that pepsi is horrible for you, but I enjoy it, so I'm not going to stop unless I develop diabetes or another condition that forces me to. I'd rather live to be 50 doing all the things I love than live to 80 always worrying about what's healthy and what isn't.

 

[Thorns Have Roses]

^In that case I recommend taking up pipe or cigar smoking. With those you don't inhale so your lungs won't be so bothered, and since you take larger amounts at once for a longer period of time (at least a half hour, with two hours being easily possible with a larger cigar like a double corona), you won't have to smoke as frequently.

Also, it tastes a hell of a lot better (pipe would be the cheapest option, after the initial investment. And don't buy the prepackaged pipe tobacco they sell at most places, go where you can get it out of like a glass jar by the ounce, they're more likely to have good blends with that).

 

[keanhe]

N-Acetyl-L-Tyrosine 300 MG x 2
Biopterin 25 MG x 2
P-5-P 5 MG x 2
Pyritinol 400 MG x 2
Aniracetam 750 MG x 2
L-Theanine 100 MG x 2
Lithium 5 MG Daily
Niacinamide 500 MG x 3
Noopept 10 MG x 2
Acetyl-L-Carnitine Arginate 500 MG x 2
Ginkgo Biloba 120 MG x 2
Acetyl-L-Carnitine 500 MG x 2
Omega 3 Oil 1000 MG
High potency Multivitamin/mineral
Astaxanthin 4 MG Daily
B-Vitamin Complex 100 Daily

This is the current regimen I've been taking. I really can't say enough positive things about these supplements. I was diagnosed with an autoimmune disease in September of 2010 that had neurological implications. I had became aphasic, though I could think. My thinking process changed as well, in my opinion for the better; I no longer really have ANY background noise in my head at any time (if that makes sense). After about two months of these symptoms and a few more, I began walking again (lumbar spine implications), my memory improved drastically (severe short term symptoms) and talking drastically better. I had a new perspective on life and became motivated to practice medicine. I enrolled in college that spring, 2010. I'm still attending college, and I've been utilizing those listed supplements during the last year of my college career [May 1st, 2011 to now - 1 year usage]. I've been working full time the last year and a half, and I've managed to complete my associates degree a term early with honors. I'll be attending USF in fall, majoring in Biomedical Science. I can't wait to attempt to use these supplements to my curriculum.

In my past, I've also been quite an addict. Not to any extreme extent, but I'm certainly a self admitted addict. I've only drank, smoked marijuana, snorted a few anti-anxiety pills, and downed a few vicodins. All extremely infrequently except the marijuana, of which I am a daily user. I suffer from quite a bit of pain, and I function a lot better under marijuana's influence as opposed to a few vicodins. Sour Diesel at the moment, 99 percent of the time the strain is amazing. Despite my drug use, my G.P.A. (3.85) and job don't suffer. I've never been arrested. There are no little mes running around. I guess that makes me a functioning addict.

This stack makes marijuana really addictive to me. It makes the high feel so much more euphoric... and with some music and bass, ugh. There's something wrong with how much I actually enjoy it. The high is ridiculously clear headed and a ton more psychedelic as opposed to heavy body load. There is no body load, it's all in your head. Seriously, listening to music. Ugh.

General effects of the stack, in my instance, are greatly increased energy, no mental fatigue (even after 9 hour textbook reading sessions), pleasant mood, increased motivation, greater abstract thinking, feeling of mental acuity, increased confidence, less need for sleep (this was never my strong point, but it doesn't suck nearly as much when I get 4-5 hours now), and quicker mental access (remembering items). I feel that the most profound supplement I take is noopept, and it's also great for marijuana as well (makes my highs a bit more intense, ups apathy a bit, calms me down, overall boost, especially with music). It's much easier for me to function under the influence when supplementing with noopept, not to mention the other supplements don't do a bad job as well. No change in effects associated with alcohol.

If you only had to put up 50-75 dollars a month to feel mentally sharper, function a bit quicker, feel a bit better, and eliminate unnecessary anxiety, wouldn't you? I'll continue to utilize these until I reach my goal, and I hope that I get the opportunity to do some great research with these compounds. I hope this aids someone in their decision to give nootropics a try. I'd have to say that my life has become drastically easier due to my present day mental capacities, something I result directly to nootropics, as it certain didn't exist before hand.

Check out how cool astaxanthin is too, if you've never heard of it

 

[Survived Abortion]

Okay, I've tried to word this in as least a condescending way as possible, but I'm afraid it will still come across as arrogant. So be it.

I still enjoy smoking very much. Why would I quit doing something that I enjoy, even if it has bad health effects?

You just gave the answer yourself - because it has bad health effects (not to mention poisoning everyone else's precious air). There are things that most of us would enjoy doing 24/7 if we could, but we don't do them because we've already learned that the fleeting period of fake "pleasure" is not worth the misery that would ultimately ensue, or the negative consequences it would have for others. Some people like gambling, but most people are clever enough not to get sucked in to it because they know it is an empty future, a worthless dream, contantly chasing a phantom dopamine buzz. Addiction to gambling leads to social degradation, as do all mindless habituations. If you're going to try and defend your bad habits by saying that you're not going to give them up because you enjoy them, then don't come whining to the rest of the world about feeling depressed and hard done by.

Also, I think you'll find that most people who smoke say they enjoy it, but they don't really. That "enjoyment" is simply illusory, since it arises from the cessation of the craving for nicotine (and the psychological fix of sucking on a tit made of rolled paper and leaves, the equivalent of sucking your thumb and rocking yourself to sleep).

Smokers are just slaves to the tobacco industry (who really don't give a fuck about you and your health) and of course the government, who skim the cream off of the revenue generated. They don't care about you. They don't care if you get cancer, emphysema, asthma, high blood pressure, stroke, gangrene, malnutrition etc. The money they make more than covers the health bills. Whilst smokers pour money in to the government coffers by willingly poisoning their bodies - making tobacco addicts nothing more than disposable money harvesters - the empire of shit flourishes happily, and the super-rich elite laugh at suckers like you who are willing to sacrifice their health for some faceless corporation's wealth.

I enjoy drinking pepsi. It's been well established that pepsi is horrible for you, but I enjoy it, so I'm not going to stop unless I develop diabetes or another condition that forces me to.

So you're going to wait until you're fucked over to decide that a particular course of action was born of utter stupidity? Diabetes isn't just not being able to eat sugary foods. It is a condition which causes system-wide problems, many of which will inevitably be devastating to the health and happiness of the individual with the condition. I've personally witnessed a family member decline in health in horrendous ways - and finally die - because of diabetes. It's no joke.

Again, don't go crying to your doctor if you haven't even bothered to take the necessary pre-emptive action to prevent problems whilst being fully aware that your habits will lead to such problems. You remind me of the kind of person who spends themselves in to ridiculous debt and then goes and tries to sue the credit card companies. Or smokers who get lung cancer and then think they have the god given right to sue the tobacco companies. Some folk aren't even aware that what they are eating or drinking may be detrimental to their wellness, but are at least willing to listen to those who inform them otherwise. It's the people who do know, but guffaw "fuck it, you only live once" who irritate me.

Knowingly treating youself with disrespectful abandon is the highest insult to all other beings who share the universe with you. It's the equivalent of hiring a rental car for a month, driving like a prick and doing loads of handbrake turns and generally smashing the shit out of it, and then returning it to the rental company with a smile on your face.

I'd rather live to be 50 doing all the things I love than live to 80 always worrying about what's healthy and what isn't.

And that includes poisoning yourself intentionally? What a waste. This is the reason the world is in the state it's in today. I call it 'Garbage Culture', a culture of unparallelled greed and squander. Huge piles of domestic trash littering landscapes across the world, an unsustainable addiction to oil, strip mining of the planet's resources just so people can have their five minutes of fame before they move on to the next consumable object like barbarious trolls with ADHD. We're witnessing ecological devastation on a scale never seen before in milennia of human history, and it's because of people's stupidity.

You may realize once you've grown up a bit that happiness isn't necessarily in chasing the next high, and that actually, such behaviour only leaves you with a mountain of mess to clean up afterwards. It's not even about how long you live. It's about the quality of life in that time. Do you want to spend the last few decades of your life in and out of hospital with circulatory disorders and ulcers, just becuase your youthful self wanted to rebel? I think you'll find most older folks who have smoked for a good portion of their lives will tell you that the shitty effects are not even slightly worth the slight buzz you may get from a lifetime of fulfilling nicotine cravings. You will never understand the pain and suffering of a critical health condition until it hits you right in the face.

Nobody's even saying you have to worry about what's healthy and what's not. If you engage in discovering what leads to wellness, it's not even a chore. It's certainly not difficult to find such things out for yourself.

 

[Cyanoide]

Noopept was more effective than I ever could have imagined. I wrote about 30 mg noopept while on 90 mg MXE almost making me sober in another thread. This is definitely very effective stuff. Not only does it remove some obsessive thoughts I sometimes have and increase my mental focus to a level I even didn't knew existed; it also relieves anxiety and depression more effectively than any SSRI I've ever tried. My vision is crystal clear, everything looks crystal sharp, and my confidence is boosted (not in the same way stimulants boost my ego, I just feel confident).

I actually read about someone comparing (very) high doses of noopept to MDMA without euphoria. While I disagree with that statement there's a definite feeling of serenity and being at peace with yourself with high doses. No anxiety or worries. But noopept does make me more "cold" and less empathetic (more rational and calculating however), however it's not like I've become a robot.

The "slight" problem is I feel a bit like a guinea pig with noopept, although I know there are several studies about it. It also totally removed the slurry speech MXE induces in me. This stuff just seems too good to be true. What are the donwsides/dangers? I know this stuff is non-toxic but all this has to come with at least some kind of price? I'm a newbie in the world of nootropics, but it's quite amazing what noopept does.

Edit: I don't use noopept every day or for long periods, its effects are felt almost immediately (though they keep bulding up a few days).

 

[keanhe]

Noopept was more effective than I ever could have imagined. I wrote about 30 mg noopept while on 90 mg MXE almost making me sober in another thread. This is definitely very effective stuff. Not only does it remove some obsessive thoughts I sometimes have and increase my mental focus to a level I even didn't knew existed; it also relieves anxiety and depression more effectively than any SSRI I've ever tried. My vision is crystal clear, everything looks crystal sharp, and my confidence is boosted (not in the same way stimulants boost my ego, I just feel confident).

I actually read about someone comparing (very) high doses of noopept to MDMA without euphoria. While I disagree with that statement there's a definite feeling of serenity and being at peace with yourself with high doses. No anxiety or worries. But noopept does make me more "cold" and less empathetic (more rational and calculating however), however it's not like I've become a robot.

The "slight" problem is I feel a bit like a guinea pig with noopept, although I know there are several studies about it. It also totally removed the slurry speech MXE induces in me. This stuff just seems too good to be true. What are the donwsides/dangers? I know this stuff is non-toxic but all this has to come with at least some kind of price? I'm a newbie in the world of nootropics, but it's quite amazing what noopept does.

Edit: I don't use noopept every day or for long periods, its effects are felt almost immediately (though they keep bulding up a few days).

What route of administration did you with noopept? As far as available literature is concerned from a few sources, no dangerous side effects have been reported. It doesn't seem to cause harm with chronic use as well.

[Preclinical study of noopept toxicity].

Abstract
Within the framework of a preclinical investigation, the new nootrope drug noopept (N-phenyl-acetyl-L-propyl-glycine ethylate) was tested for chronic toxicity upon peroral administration in a dose of 10 or 100 mg/kg over 6 months in both male and female rabbits. The results of observations showed that noopept administered in this dose range induced no irreversible pathologic changes in the organs and systems studied and exhibited no allergenic, immunotoxic, and mutagen activity. The drug affected neither the generative function nor the antenatal or postnatal progeny development. Noopept produced a dose-dependent suppression of inflammation reaction to concanavalin A and stimulated the cellular and humoral immune response in mice.

(http://www.ncbi.nlm.nih.gov/pubmed/12025790)

Besides, if noopept has the purported amyloid interaction I keep reading about in the studies that have been conducted on it, wouldn't it essentially negate the most crucial aspect of Alzheimer's pathology? I'm surprised that more individuals aren't utilizing such an amazing compound; a simple review of literature suggests that anti-inflammatory, neuroprotective, and many other desirable traits are associated with noopept.

From my experience with it, I'm certainly glad that it is available without limitations here in America. It's an effective supplement and certainly does the job when needed. I enjoy using it before developing speeches, as it really gives me a linguistic quality that flows wonderfully. Before speeches as well, as it certainly makes your mood more pleasant, calms your nerves, and allows for much easier focusing due to clarity of mind. I'm hoping to find the "next" noopept-like nootropic soon, as these substances have been nothing short of extraordinary to me.

 

[Cyanoide]

What route of administration did you with noopept? As far as available literature is concerned from a few sources, no dangerous side effects have been reported. It doesn't seem to cause harm with chronic use as well.

I take it sublingually. There are conflicting reports about its effectiveness when taken orally, but e.g. according to this study it crosses the blood-brain barrier in an unmodified state when taken orally. So it seems its oral bioavailability is quite high. I don't know why some claim it's not effective when taken orally.

The thing is I can't take my milligram scale and start measuring doses from a white powder to take sublingually at work. I have lots of empty capsules I could put the noopept in which would be much more convenient than taking it sublingually. Besides, it burns a bit when taken sublingually, which can't be good for the mucous membrane in the tongue and mouth.

Have anyone here taken it orally and is it effective? I've now started taking 20 mg twice a day. Sometimes I take 30 mg twice a day. I've also added L-Theanine to my "stack" and so far I've been quite satisfied with its effects.

I've been trying just of curiosity and as a guinea pig how noopept interacts with other drugs. One thing has become totally clear (at least for me). It should not be combined with stimulants! Not only does it potentiate them but it causes a drastic increase in my heart rate and blood pressure, as well as causing serious heart arrhytmia. I had real concerns about my heart (it was a recreational dose of a stimulant). With MXE it goes fine. No problem with alcohol and Lyrica either (just make me feel much more sober). I've yet to try it with psychedelics.

I definitely recommend to stay away from stimulants while on noopept. This is not piracetam, noopept is much more powerful and can have quite profound effects in just 15 minutes.

Lastly L-Theanine does not go well together with noopept for me (although many combine these two). I'm not sure if it's the noopept causing it or just me not tolerating L-Theanine but I get chest pains and an elevated blood pressure from it (when it should work in the opposite way and lower the blood pressure). I tried to cut my dose of L-Theanine from 200 mg to 100 mg but it doesn't help.

 

[cryptix420]

Noopept has caused an extreme level of irritability for me, which has made me save it for only certain days now.