The Big & Dandy Methoxetamine Thread: 9th dose - Tolerance Schmolerance

[Sweetshare]

I'm going to take a small dose and go cycling. I hope it is not dangerous.

 

[Survived Abortion]

i only use them once a week, its the only thing that gets me to sleep. once a week is ok right? 20mg once a week. i know ive recommended that combo a bit too much, however if people get addicted to them thats their own stupid fault, the risks are obvious

I didn't mean any personal offence, and I don't like singling anyone out in that way. It's just something I feel strongly about because of personal experiences, and I suppose it just hit a nerve in that respect. If you can use responsibly good for you.

I really do have the best intentions, and I know you do too. Athough I might seem imposing and forthright, it truly comes from a place of love and care. I don't want anyone to go through the hell I went through.

With this particular batch, I've noticed more after effects, such as head pressure, almost headache like. A general feeling of tiredness seems to take hold after a dose wears off, despite eating healthy and staying hydrated. Just doesn't feel as clean as before.

These are typical MXE after effects, regardless of batch.

 

[Nicklazz]

Not anyone have any idea why my MXE is not working as good as it used to do? Did a post on page 8.

Tried again today still the same. Could it be because i have taken some etizolam a few hours before i do the MXE?

 

[TheProdigalSon]

Hmmm, I am not really sure about MXE. I tried 20mg up the nose, and then another 20mg forty five minutes later. I watched a movie, it was hard to follow but not so much that I didn't understand what was happening. Now here it is 4 hours later and I just kind of feel like my body is "lagging" and I am kinda bored. I have my headphones on and music still sounds awesome, but eh.

If I just go ahead and eat, will it be safe to re-dose an hour from now and then just go lay down and listen to some music? Maybe 30-40mg?

 

[Nicklazz]

Hmmm, I am not really sure about MXE. I tried 20mg up the nose, and then another 20mg forty five minutes later. I watched a movie, it was hard to follow but not so much that I didn't understand what was happening. Now here it is 4 hours later and I just kind of feel like my body is "lagging" and I am kinda bored. I have my headphones on and music still sounds awesome, but eh.

If I just go ahead and eat, will it be safe to re-dose an hour from now and then just go lay down and listen to some music? Maybe 30-40mg?

Yea that should be fine, no problems with that

 

[Jesusgreen]

Not anyone have any idea why my MXE is not working as good as it used to do? Did a post on page 8.

Tried again today still the same. Could it be because i have taken some etizolam a few hours before i do the MXE?

How long have you been using it? Like other drugs MXE use causes tolerance over time. There could also be some tolerance to the dopaminergic effects if you're been taking a lot of ethylphenidate lately - and imo the dopaminergic effects are more pronounced than the dissociation until much higher doses when snorting MXE rather than taking it orally/sublingually so you might be used to a lot more stimulation than you get now.

 

[Nicklazz]

How long have you been using it? Like other drugs MXE use causes tolerance over time. There could also be some tolerance to the dopaminergic effects if you're been taking a lot of ethylphenidate lately - and imo the dopaminergic effects are more pronounced than the dissociation until much higher doses when snorting MXE rather than taking it orally/sublingually so you might be used to a lot more stimulation than you get now.

Thanks for your answer ! I took a break from taken it, the break was a couple of weeks, before that I only did small doses 20-40mg a few times a week. I have done a lot of Ethylphenidate lately. But i have got my sleep and food etc.

So do you think I just should wait a week or more without taking mxe or Ethylphenidate and see if the MXE works better? It would be sad if I just wasted it, don't got a lot left

 

[idontdothizz]

Thanks for your answer ! I took a break from taken it, the break was a couple of weeks, before that I only did small doses 20-40mg a few times a week. I have done a lot of Ethylphenidate lately. But i have got my sleep and food etc.

So do you think I just should wait a week or more without taking mxe or Ethylphenidate and see if the MXE works better? It would be sad if I just wasted it, don't got a lot left

I think it will. I had this same problem and when I cut my use back to once a week, the magic came back. And I knew it wasn't the batch anyways because when I give it to other people they have a huge smile and squinty eyes and laughing and thanking me and telling me how this is the best drug they have ever done all night.

 

[Nicklazz]

I think it will. I had this same problem and when I cut my use back to once a week, the magic came back. And I knew it wasn't the batch anyways because when I give it to other people they have a huge smile and squinty eyes and laughing and thanking me and telling me how this is the best drug they have ever done all night.

Yea it can't be the batch I have because it's still the same I got the great high from weeks ago, but damn this is wierd.. Just have to wait I guess.

 

[fuckUwil$on]

So I know vender talk isn't allowed and whatnot but has anyone been following what appears to be a raid by the feds on 4/20. A certain site is down, shit got real, it appears as if "the good old days" are over, at least for now. Really got to cease and conserve my sexy mexxy for my stash is dwindling, and I am now out of the loop, and probably will stay out of the "scene" for a period of time. This really kind of sucks. I guess "good things" can't last forever, time to move on, for the time being...

 

[J.Wallace]

So I know vender talk isn't allowed and whatnot but has anyone been following what appears to be a raid by the feds on 4/20. A certain site is down, shit got real, it appears as if "the good old days" are over, at least for now. Really got to cease and conserve my sexy mexxy for my stash is dwindling, and I am now out of the loop, and probably will stay out of the "scene" for a period of time. This really kind of sucks. I guess "good things" can't last forever, time to move on, for the time being...

A few sites went down, and my vendor went offline and is now email and referral only. They are just keeping shit on the down low from now on.

I have a few questions abot MxE. I understand it depletes Dopamine, correct? Perhaps the rise in tolerance is not so much tolerance, but a lack of dopamine in our brains which is causing us to not feel the full effect of this substance.

I recently got a new batch, and it's perfectly good. I just can't feel much from it anymore. I can take bumps and bumps and not got fucked up anymore. I'm a little concerned it may be from my dopamine receptors being used up and needing to recover. Could this be the case? Cause now all I get is a speedy kind of high, not much disassociation anymore.

 

[Euphoric Status]

So I know vender talk isn't allowed and whatnot but has anyone been following what appears to be a raid by the feds on 4/20. A certain site is down, shit got real, it appears as if "the good old days" are over, at least for now. Really got to cease and conserve my sexy mexxy for my stash is dwindling, and I am now out of the loop, and probably will stay out of the "scene" for a period of time. This really kind of sucks. I guess "good things" can't last forever, time to move on, for the time being...

This is definitely not the end of things. Give it some time and things will slowly recover.

 

[golden1]

Dopamine depletion isn't really a worry IMO, even with stimulants. as if you get enough protein, it should easily restore your dopamine levels. Downregulation of the receptors would be what causes tolerance.
Specifically in your case it sounds like NMDA receptor tolerance, not dopamine(hence the speedy high and lack of disassociation).

Hope that helps, also It's probably not smart to use it so often(speaking to the wrong thread here hahahaa), considering it is literally a NEW drug and not designed or tested by a pharmaceutical company with very little history available to infer longterm safety(also afaik no studies at all done on pharmacology/toxicity). Plus you don't run into tolerance if you space it conservatively. BTW, I'm not saying I'm Mr.Careful, I do the same shit with unresearched drugs, but I feel I should say that since it's the truth regardless of my own actions Of course I'm sure you all know the risks and have been reminded before.

Personally I usually go crazy on a new drug for a little while and then back off and use it responsibly, my own little compromise hehe.

As to answer your question J.W, it is most likely your NMDA receptors and to a lesser extent dopamine receptors, the cure to this is just time(like 3 days? or less? depending on tolerance way more)

 

[idontdothizz]

So I know vender talk isn't allowed and whatnot but has anyone been following what appears to be a raid by the feds on 4/20. A certain site is down, shit got real, it appears as if "the good old days" are over, at least for now. Really got to cease and conserve my sexy mexxy for my stash is dwindling, and I am now out of the loop, and probably will stay out of the "scene" for a period of time. This really kind of sucks. I guess "good things" can't last forever, time to move on, for the time being...

anyone mind telling me what he is talking about?

 

[Thorns Have Roses]

I have a few questions abot MxE. I understand it depletes Dopamine, correct? Perhaps the rise in tolerance is not so much tolerance, but a lack of dopamine in our brains which is causing us to not feel the full effect of this substance.

I recently got a new batch, and it's perfectly good. I just can't feel much from it anymore. I can take bumps and bumps and not got fucked up anymore. I'm a little concerned it may be from my dopamine receptors being used up and needing to recover. Could this be the case? Cause now all I get is a speedy kind of high, not much disassociation anymore.

Dissociative effects not caused by dopamergic action, but that at NMDA receptors. Acute tolerance to dissociative effects aside from long term dissociative tolerance has been noted with this drug by numerous persons, including myself. It would be best to treat it like a psychedelic in this regard, take a couple weeks off and see if this issue hasn't alleviated itself.

Increasing your dosages to combat this acute tolerance isn't worth what it'll end up doing to your longterm tolerance (if you want to preserve your ability to enjoy NMDA antagonists in the future).

And no vendor talk folks, if you want to gossip about the state of RC availability, your purposes would be better appreciated and more productive if you took it to a sourcing board.

 

[Jesusgreen]

Yeah, as mentioned, the fact that you're still getting the stimulation means you've built up a tolerance to the dissociative effects in particular. Unfortunately dissociative tolerance can be very very long lasting and hard to get rid of. Previously when I used Ketamine regularly for a while it took a several month break to get my tolerance anywhere near its old level, but even then it was still there - and although I had been using it regularly it was over quite a short period of time.

Dissociative tolerance can be quite nasty so I'd recommend avoiding getting there in the first place if you want to be able to enjoy them.

I'd recommend a few weeks or a month break and then to reduce your frequency of dosing if you've already got yourself a tolerance built up.

 

[ColtDan]

think this has been mentioned before but does MXE make anyone sweat like mad in bed? i did some MXE saturday night, sunday night in bed i was sweating like crazy all night

 

[peacephrog]

ok

the batches I was getting 6 months ago were yummy short lived (3_5)hours and redose........lots of fun and squirrlly shit........nothing to crazy

last batch fluffywhite 60mg up the nose and your flying.........problem is I ,feel no need to redose cause I can't fucking sleep! Fun time, but what's with the all of a sudden I'm up for EVER and don't even take a second dose (first time round I'd lick it a few times and repeat 3 times and calling it a night.......now I do 1 dose and never fucking sleeep....WTF?

 

[the toad]

@peacephrog

I had this same issue but never really figured out what it was for sure... first few shipments i got were amazing but later ones seemed much more spedy and not nearly as much psychedelic effect... they looked similar and smelled and tasted the same and came from the same vendor so i didnt really think much about it being different product and assumed my overuse was to blame, but then i found some of my old stock that id forgot about and it still worked the same as it used to so im fairly certain at least one wasnt pure...

 

[Elinisti]

Has anyone else noticed a huge cross tolerance with Zolpidem? Last year 40mg was enough to mix me up completely. After around half a year of MXE usage (used about 10-15g) Zolpidem didn't have any special effect even after 200mg. Strange.