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Zylofuramine

negrogesic

Moderator: BDD, OD
Staff member
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Jul 21, 2002
Messages
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I just ordered this odd ball compound. Its an old stimulant/anorectic.

I would imagine this is a prodrug of some amphetamine (in this case, n-ethyl-amphetamine?). Or could would it not necessarily be a prodrug?

Will sample it this weekend.

Not expecting a recreational compound but rather a functional stimulant. Always nice though when a functional stimulant has a slight reinforcing component to it (makes it more motivating).
 
I've got some on the way too but got a bit overzealous and ordered a larger amount, should have just gone with the smallest amount and then decided to order more if warranted. I guess I like gambling my hard earned funds more than I realized.

I really hope it's better then the last few 'stims' they released. diET-fencafamine, n-ethyl-cypenamine and n-ethyl-cypenamine just weren't all that great to me. A one off low to medium dose of each is ok, not really euphoric or functional just sorta 'there' in a quasi stimulant like sense. They can provide a short recreational sensation if snorted but it isn't all that worthwhile for me. They seem to get quite yucky if pushed too far. For example: N-methyl-cypenamine left me feeling almost stoned like mixed with a quasi dissociated like feeling on top of feeling semi cracked out after a night of many small redoses. Wasn't really pleasant and the way I felt as I waited a long time to go to sleep was best explained as yucky, and the two others feel quite similar to me so I decided not to attempt such use with them as I suspect it'll be the same. So they aren't great functionally or recreationally IMO.

Fingers crossed this one atleast is a decent functional stim. Don't need, want or expect this one to be recreational.

Any ideas what the dosage range will be like? Person on Reddit said they took 40mg a day for a few days but didn't provide much else. I tried searching around since they say this was discovered/developed in the 1960s as a potential treatment of dementia but haven't found anything yet.
 
Just checked, and the report on Reddit I mentioned (was posted 2 days ago) has been deleted. Too bad, it contained the only report(s) of usage that I've been able to find so far, everything else I've found is just idle speculation that's happened over the years.

In that deleted thread another Reddit user reported having tried it at 40mg per day for a few days. I'm recalling this from memory though, so hopefully I remember correctly. When I get my zylofuramine I'll do a proper titration up to find optimal dosing, no intentions of just jumping in. Regardless I'd still be interested to hear any thoughts on dosage or metabolism if anyone cares to theorize.
 
I've got some on the way too but got a bit overzealous and ordered a larger amount, should have just gone with the smallest amount and then decided to order more if warranted. I guess I like gambling my hard earned funds more than I realized.

I really hope it's better then the last few 'stims' they released. diET-fencafamine, n-ethyl-cypenamine and n-ethyl-cypenamine just weren't all that great to me. A one off low to medium dose of each is ok, not really euphoric or functional just sorta 'there' in a quasi stimulant like sense. They can provide a short recreational sensation if snorted but it isn't all that worthwhile for me. They seem to get quite yucky if pushed too far. For example: N-methyl-cypenamine left me feeling almost stoned like mixed with a quasi dissociated like feeling on top of feeling semi cracked out after a night of many small redoses. Wasn't really pleasant and the way I felt as I waited a long time to go to sleep was best explained as yucky, and the two others feel quite similar to me so I decided not to attempt such use with them as I suspect it'll be the same. So they aren't great functionally or recreationally IMO.

Fingers crossed this one atleast is a decent functional stim. Don't need, want or expect this one to be recreational.

Any ideas what the dosage range will be like? Person on Reddit said they took 40mg a day for a few days but didn't provide much else. I tried searching around since they say this was discovered/developed in the 1960s as a potential treatment of dementia but haven't found anything yet.

What did you think of the n-ethyl-cypenamine? It seemed like strong functional stimulant but had a surprisingly bad comedown. I have the diethylfencamfamine too but i only tried it once.
 
What did you think of the n-ethyl-cypenamine? It seemed like strong functional stimulant but had a surprisingly bad comedown. I have the diethylfencamfamine too but i only tried it once.

Feels quite similar to the n-methyl-cypenamine to me but does seems to be a slightly better stimulant which was counter intuitive to me. However it felt gross similar to my n-methyl-cypenamine exp when I've tried redosing it a couple times over an evening. Though I haven't tried taking a single large dose yet, maybe that would be better then multiple small doses spread over time. But I don't think so, these three just don't seem to agree much with me. Maybe something about my makeup, perhaps they perform better in others? They seem to be lacking something that other good stimulants have and they have this ickyness in their effects that has been working great as a deterrent to their use.

On the other hand, I think there may be some potential in using these along side other stimulants. For example, I tried a small dose of n-ethyl-cypenamine on top of some cyclazodone that I had taken hours earlier. The n-ethyl-cypenamine seemed to really kick things up a notch and the exp was actually quite pleasant both in a 'get stuff done' way but also it felt quite good too. I want to experiment a little more with this and try in combo with other stimulants, not sure yet if it was a one off or if I'm on to something.
 
This compound looks like it could somehow be made from phenylalanine...
 
@Heinous J Man just go to sleep already, you're ruining this thread.

Curious about the effects of this drug. I don't think n-ethylamphetamine would be a major metabolite though.

Hopefully a mod can come along and clean up this thread up a bit when they have the time. Pretty please?


Is there any reason to think that the parent molecule will not be active in its own right? Or should we expect it to only be active from it's metabolites? I realize we are likely mostly still in the realm of conjecture, just curious what you guys may think.

I should be able to begin trialing this within a day. I usually try to avoid making any public comments until I've had at least several experiments, so I probably won't have much to say until sometime next week. Sounds like negro will also be sampling this this weekend.

🤞 hope it's a decent one but I don't have my expectations too high... I think...
 
Hopefully a mod can come along and clean up this thread up a bit when they have the time. Pretty please?


Is there any reason to think that the parent molecule will not be active in its own right? Or should we expect it to only be active from it's metabolites? I realize we are likely mostly still in the realm of conjecture, just curious what you guys may think.

I should be able to begin trialing this within a day. I usually try to avoid making any public comments until I've had at least several experiments, so I probably won't have much to say until sometime next week. Sounds like negro will also be sampling this this weekend.

🤞 hope it's a decent one but I don't have my expectations too high... I think...

Did you try it?

I tried a 5mg allergy test and with no effect.

20mg orally had only mild effect. Doses might be in the 50mg+ range.

The powder tastes like an amphetamine. Tastes like it would vape well (not going to try).

Became more active when I combined with PPAP. Appetite suppression is disproportionately strong relative to its other effects.
 
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Did you try it?

I tried a 5mg allergy test and with no effect.

20mg orally had only mild effect. Doses might be in the 50mg+ range.

The powder tastes like an amphetamine. Tastes like it would vape well (not going to try).

Became more active when I combined with PPAP. Appetite suppression is disproportionately strong relative to its other effects.

I've only tried it a few times in increasing dosages, trying to give myself a day or so break at least in between. I'm still not quite sure what I think of this one yet, still deciding.

It does have that particular smell/taste to it. Reminds me of some other stimulants I've tried in the past but can't remember which exactly maybe other amphetamines, not sure. Not entirely pleasant but not vile either. Seems to cause a very slight numbing sensation as well?

The parent molecule seems active to me though it may still also have active metabolites as well though I have no idea for sure. Seems to kick in rather quickly from oral ingestion, first effects felt within 15-20 min on an empty stomach. Works via nasal insufflation as a slight rush and effects seem to start within minutes but I haven't yet explored this beyond a small amount just to see whether it was a viable route. Also tried vaporization which works but more on that later.

20mg oral is pretty mild, I tried 40mg and this seems to be more of a proper dose but I still want at least another trial before properly formulating an opinion. At 40mg, it caused a decent amount of stimulation but the first 1.5-2 hours weren't particularly pleasant to me. I found myself anxious with nervous energy that was difficult to direct. Kinda just wanted it to end. Reminded me more of the feeling I get from reuptake inhibitors then from releasor, but I do not know which it actually is. Some compulsion to redose was present but not overly so. Once this 1.5-2 hour come up and peak subsided, it mellowed out into a nice stimulation that gradually wore off. Found myself productive during this time, felt good too unlike the peak. I didn't experience any crash and was able to sleep without any issues about 8 hours after dosing. It was unusual, instead of paying for the experience in a crash (as in what goes up must come down) it was more like the payment was made up front during the comeup and peak and then the my discomfort was rewarded with a pleasant ride back down. Felt sleepy by bed time and had a good nights rest. Don't know yet if this was a fluke, I plan to give oral another try in a few days at a slightly higher amount, maybe 50mg.

It seems to vape well when properly heated and produces a large amount of white vapor / smoke. Not really pleasant tasting/feeling but not overly disgusting/uncomfortable. There is somewhat of a rush and decent compulsion to redose but not overly so like with seen with a pyros or most cathinones when vaped. I don't have too much exp vaping amphetamines so it's hard to compare to those.

I tried going balls to wall with vaping (large amount vaped in a short amount of time) yesterday but I didn't like the results so I won't be doing that again. Once I got to a certain point the effects got weird. It's hard to describe exactly but it was almost like this one has enough binding at other receptor sites or something (no idea if this is actually true) it just felt bizarre. The usual effects of vaping too much stim too quickly was there (stimulation physical and mental, slight paranoia, etc) but it also somehow also felt sedating, dissociative like or like I was experiencing intense derealization. Almost felt like I needed to lay down, like I was on the brink of passing out maybe from rapid change in blood pressure, I don't know. I was NOT enjoying myself but still some compulsion to dose even more was still present though not strong enough to overcome my better sense. Also very little to no enhancement of the perverted kind, I wasn't at all interested in porn or masturbation like I would be when vaping most other stims. The next several hours were uncomfortable but even with such a large amount vaped it still wore off and allowed me to sleep by about 8 hours later.

So I don't recommend vaping but if one decides to try then stick with sane amounts. I won't be repeating this, just gonna give oral one more try and probably dispose of the rest unless I find it particularly good - which I'm not
expecting.
 
Interesting, let us know how it goes. The only one of the stims from that place I have tried that I like is n-methyl-cyclozodone, I find it to be a strong functional and slightly rerceational stimulant. I was using it regularly for a bit, I bought a gram a little while ago, but lately it's given me pretty bad headaches the last 3 or 4 times I've used it so I've shelved it for the time being.

I'll clean the thread up now.
 
Interesting, let us know how it goes. The only one of the stims from that place I have tried that I like is n-methyl-cyclozodone, I find it to be a strong functional and slightly rerceational stimulant. I was using it regularly for a bit, I bought a gram a little while ago, but lately it's given me pretty bad headaches the last 3 or 4 times I've used it so I've shelved it for the time being.

I'll clean the thread up now.
Yeah i agree and prefer n-methylcyclazodone to 2-FMA. Has more mood enhancing effects.

60mg and over feel serotonergic. So much so that 150mg in a day left me with distinct post serotonin release (depletion) symptoms. It is very stimulating at high doses and can be incredibly productive. Very long lasting though. Nice and smooth. Only took giant doses with benzos. In fact i only took giant dosea because i had taken benzos.
 
Yeah adding some etizolam would always clear up the headache. Weirdly I didn't get any headaches until the last few times I used it, I used it probably 30 times (in 2 separate purchases separated by a year or so) without a single headache, including some large accumulated dosages of 60mg or more. Now I can take 10mg and will develop a headache after a few hours, it sucks. I also find it extremely productive and motivating, and relatively euphoric/slight hypomanic, and smoother than 2-FMA as well. Other than the headaches I've gotten recently.
 
I tried going balls to wall with vaping (large amount vaped in a short amount of time) yesterday but I didn't like the results so I won't be doing that again. Once I got to a certain point the effects got weird. It's hard to describe exactly but it was almost like this one has enough binding at other receptor sites or something (no idea if this is actually true) it just felt bizarre. The usual effects of vaping too much stim too quickly was there (stimulation physical and mental, slight paranoia, etc) but it also somehow also felt sedating, dissociative like or like I was experiencing intense derealization. Almost felt like I needed to lay down, like I was on the brink of passing out maybe from rapid change in blood pressure, I don't know. I was NOT enjoying myself but still some compulsion to dose even more was still present though not strong enough to overcome my better sense. Also very little to no enhancement of the perverted kind, I wasn't at all interested in porn or masturbation like I would be when vaping most other stims. The next several hours were uncomfortable but even with such a large amount vaped it still wore off and allowed me to sleep by about 8 hours later.

expecting.
I noticed that target predictors show a lot of unusually high predicted activity at Sigma-1, mu/delta-opiod (oddly not kappa) and b1.

If either sigma or delta are hit hard shit could indeed get weird. The predictions often showed affinity (usually higher, sometimes many, many times higher than any NET/NE/DAT/D1) for some of these 4 receptors (All agonist) in cyclazodone, zylofuramine, morphodrol and thozalinone.
 
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