Zyban & Speed

[zaki]

Zyban (Bupropion) is the quit smoking aid that i always thought blocked the nicotine receptors, however i learnt today that this is untrue and infact they dont really know exactly why Zyban works in helping people quit smoking.

What i also learnt today is that Zyban is actually a re-uptake inhibitor of noradrenaline and dopamine. Does anyone know much about this and could they shed some light on whether or not Zyban is therefor the same to amphetamines such as speed, as an SSRI is to mdma?

 

[ld50 vs ssri]

The neurochemical mechanism of the antidepressant effect of bupropion is not known. Bupropion does not inhibit monoamine oxidase. Compared to classical tricyclic antidepressants, it is a weak blocker of the neuronal uptake of serotonin and norepinephrine; it also inhibits the neuronal re-uptake of dopamine to some extent.

Bupropion produces dose-related central nervous system (CNS) stimulant effects in animals, as evidenced by increased locomotor activity, increased rates of responding in various schedule-controlled operant behavior tasks, and, at high doses, induction of mild stereotyped behavior.

Bupropion causes convulsions in rodents and dogs at doses approximately tenfold the dose recommended as the human antidepressant dose.

Not sure if this is what you are after but anyhow.

Source http://www.rxlist.com/cgi/generic/buprop_cp.htm#CP

 

[zaki]

what i wish i had was the info that my doctor had on her screen while we read through it and discussed it.

 

[Cowboy Mac]

she would have got the information from MIMS. I will get a scanner and get it scanned for you.

 

[neurotichaosis]

Sorry, I don't have the answer, but just to clarify it, are you asking if it will decrease the speed euphoria in a similar manner to how SSRI's kill E's effects???

I am curious as well...

 

[ld50 vs ssri]

Drugs Metabolized by Cytochrome P450IID6 (CYP2D6): Many drugs, including most antidepressants (SSRIs, many tricyclics), beta-blockers, antiarrhythmics, and antipsychotics are metabolized by the CYP2D6 isoenzyme. Although bupropion is not metabolized by this isoenzyme, bupropion and hydroxybupropion are inhibitors of the CYP2D6 isoenzyme in vitro. In a study of 15 males subjects (ages 19 to 35 years) who were extensive metabolizers of the CYP2D6 isoenzyme, daily doses of bupropion given as 150 mg twice daily followed by a single dose of 50 mg desipramine increased the Cmax, AUC, and T½ of desipramine by an average of approximately two-, five-and twofold, respectively. The effect was present for at least 7 days after the last dose of bupropion. Comcomitant use of bupropion with other drugs metabolized by CYP2D6 has not been formally studied.

Therefore, co-adminstration of bupropion with drugs that are metabolized by CYP2D6 isoenzyme including certain antidepressants (e.g., nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecanide), should be approached with caution and should be initiated at the lower end of the dose range of the concomitant medication. If bupropion is added to the treatment regimen of a patient already receiving a drug metabolized by CYP2D6, the need to decrease the dose of the original medication should be considered, particularly for those concomitant medications with a narrow therapeutic index.

Give these links a go.

http://www.mentalhealth.com/drug/p30-b04.html
http://www.preskorn.com/columns/0001.html
http://www.erowid.org/pharms/bupropion/bupropion.shtml
http://www.erowid.org/experiences/exp.php?ID=16856


From what i understand, Bupropion is related to amphetamines and diethylpropion.

There is Bupropion hcl (SR) which seems to be an Aid to stop smoking and there is Buproprion hcl which is in a class of Antidepressants. You could say it has properties of an ssri, but weaker activity.

 

[zaki]

thanks ld50 vs ssri,

I understand its weaker activity however i have had 2 mini binges on speed since i started taking them and on both occasions i didnt get quite as strong effects from the speed as i usually would, in saying that i think the difference is too minute to really worry me. I just find it very interesting i guess as i did and still do when i first learnt about ht1 and ht2 neurotransmitters and ssri's effects on them. I guess if i had the patience to sit through like 9 years of uni or whatever it would take to do a phd on neuro physiology then i would, however i struggled to finish my 2 year part time 6 hours a week youth work course. It took me 4.5 years to do....

Anyway i just think its an interesting topic to discuss and its motivated me to post a thread and that is rare in itself.