Yes, i read the studies of low bioavailability and quick extraction of polyphenols in the body. how they are extracted. way before they can actually be detected and possibly (probably) not do anything?, BUT thats exactly the point! from what i have gathered over the years researching this, it seems something like quercetin is needed just enough to cause a RESPONSE within certain perimeters, quick absorption and extraction. because of supposed toxicity. it becomes what it is called Hormesis, if you ever heard of it?
also, while researching polyphenols, it took me in an 180 turn to something completely new, and exciting! Our own microbiome processes every polyphenol differently for every individual! And i had this discussion with sekio about it when he argued the same BS that polyphenols are useless. I confronted him with how each individual's microbiome works unique to them and its quite impossible to determine by science YET, in point to fact, how this really works!
So yeah, our bodies main mission is to get rid of any foreign substances, including polyphenols and so on. BUT just like the toxins, even the short acting ones, they can completely remodel your organism, short or long term, without even our aknowledgement of such deity.
It needs more research though. This whole microbiome thing and how it processes each nutrient or toxin we consume is still in its infancy. BUT im skeptical and so sad because of SCIENCE and the BUSINESS side of it! we will never learn the truth because they must rather say whatever they have to say to make money and abolish all important evidence through the whole process.