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Misc Wild Dagga - Leonotis leonurus (Is it dangerous? MAOI?)


Sep 6, 2017
Is this herb dangerous in combination with foods that typically can be a problem/cause ilness or death. As in is it a MAO Inhibitor?

If it is, is it weak enough that I do not need to worry?
Have you found any research papers on this subject that deals with dangerous interactions?

Like all "Cannabis" ish drugs, I tend to get munchies. Even if the actual plant has not been reported to actually cause munchies, anything that is even slightly similar to cannabis tends to get me into a munch-ish mindset (Placebo).

I've tried researching myself on google scholar like one person suggested to another person when he asked about several different drugs. But I cannot read chemistry. I know Fe is Iron basically. But I know nothing about how it works etc.
Something about Ki Affinity (Makes no sense to me and all papers I found did not contain that word)

Especially when you see things like FeBa2 or whatever. It tells me absolutely nothing and I do not understand it, so I just wanted to ask you fine folk who do know their stuff. And would like to clear this once and for all.
It's funny really. Ask me about computers and I will know fairly well what is going on, and programming in general. But ask me if and when a metal bends. Or if something is dangerous to combine with something else and I am like a newborn baby with zero knowledge. It's frustrating to not know. I just want to sit down. Eat some good food, take a hit and relax for once and stop freaking/stressing.


Sep 6, 2017
I'm not sure what you are asking. What drug are you considering using, and what are your concerns with it?

Family :
Lamiaceae (Former: Labiatae)

Genus :
Leonotis (Former: Phlomis)

Species :
leonurus (or Leonorus)

Lion's Tail; Wild Dagga
Sedative; Intoxicant
Leonotis leonurus is a shrubby perennial growing 2-3 meters tall and producing red, orange, yellow, or white tubular flowers. The dried flowers, when smoked, provide a mild sedation reminiscent of Cannabis. They have a history of use in S. Africa as an intoxicant.

Claimed on another forum:

[SIZE=-1]SWIM has found a little gem relevant to this discussion and has tried to make it a little bit easier to for You to read. The pharmaceutical information is near the bottom.[/SIZE]


[SIZE=-1]Leonotis herba consists of the dried aerial parts of Leonotis leonurus (L.) R. Br. (Lamiaceae).[/SIZE]

[SIZE=-1]Phlomis leonurus L.[/SIZE]
[SIZE=-1]Leonotis leonurus (L.) R. Br. var. albiflora Benth.[/SIZE]

[SIZE=-1]Vernacular names[/SIZE]
[SIZE=-1]wilde dagga (A), lion's ear, minaret flower (E), unfincafincane (X), lebake (S), umhlalampetu (Sh)[/SIZE]


[SIZE=-1]Shrub 2-5 m tall, branching from a thick woody base; stem pale brown and densely pubescent; leaves simple, opposite, petiolate, coriaceous, 50-100 ´ 10-20 mm, linear, acute at apex and base, serrate in the distal half; upper surface bright green, lower surface densely pubescent; inflorescence of 3-11 compact verticils; calyx 12-16 mm long, 4 mm in diameter, calyx teeth 10, subequal, spreading; corolla tubular, bright orange, 40-49 mm long, covered with orange hairs; fruit a nutlet 5-6 ´ 1.5-2 mm, brown.[/SIZE]

[SIZE=-1]Characteristic features are: the numerous uniseriate, curved, thick-walled, warty, 2-3 celled non-glandular trichomes of leaf and stem, 60-100 m in length, particularly abundant on margin of lamina and main veins of lower leaf surface; the numerous glandular hairs of leaf and stem, with unicellular stalk and 4-celled head (up to 20 m in diameter) and yellow-brown contents; the less numerous glandular trichomes of leaf lamina, with unicellular stalk and 6-8 celled head, thick-walled, head about 40 m in diameter; cells of the lower epidermis with sinuous walls and striated cuticle, lacking stomata; cells of the upper epidermis with sinuous walls and numerous raised anomocytic stomata; single palisade layer; abundant crystal sand in cells of the mesophyll; occasional yellow hairs of the corolla.[/SIZE]
[SIZE=-1]Crude drug[/SIZE]
[SIZE=-1]Supplied in bundles comprising young leafy twigs, the leaves having a characteristic aromatic-pungent odour, bright yellow-green colour and rough texture; occasional flowers and fruits are present. [/SIZE]

[SIZE=-1]Geographical distribution[/SIZE]
[SIZE=-1]Locally common at forest margins, on rocky hillsides and river banks and in tall grassland of the Eastern and Western Cape Provinces, Kwazulu-Natal and Mpumalanga.[/SIZE]


[SIZE=-1]Identity test[/SIZE]
[SIZE=-1]Thin layer chromatography on silica gel using as solvent a mixture of toluene:diethyl ether:1.75m acetic acid (1:1:1). Reference compound: thymol (0,1% in chloroform)[/SIZE]​

[SIZE=-1]Major compounds:[/SIZE]
[SIZE=-1]yellow-mustard (Rf :0,19); yellow-mustard (Rf: 0,38); blue-mauve (Rf: 0,4); thymol (pink): Rf:0,8.[/SIZE]

[SIZE=-1]Ethanol (70%) extractive value[/SIZE]
[SIZE=-1]not less than 22%[/SIZE]​

[SIZE=-1]Volatile oil content[/SIZE]
[SIZE=-1]not less than 0,15% (0,15-0,18%).[/SIZE]


[SIZE=-1]Major chemical constituents[/SIZE]
[SIZE=-1]1. Diterpenoid labdane lactones: premarrubiin 0.00933-0.01567%, marrubiin (possibly an artifact derived from premarrubiin during extraction)[/SIZE]
[SIZE=-1]2. Tannins, quinones, saponins, alkaloids and triterpene steroids were detected in preliminary tests in our laboratories; iridoids were not detected.[/SIZE]


Dosage forms
[SIZE=-1]Used mainly in the form of an aqueous decoction, orally, per rectum and as a topical application. [/SIZE]​

[SIZE=-1]For the treatment of cough, cold, influenza, chest infections, diabetes, hypertension, eczema, epilepsy, delayed menstruation, intestinal worms, constipation, spider bites and scorpion stings and as an antidote for snakebite.[/SIZE]​

[SIZE=-1]For the relief of haemorrhoids, eczema, skin rashes and boils.[/SIZE]​

[SIZE=-1]Pharmacology / Bioactivity[/SIZE]
Anti-nematodal activity has been demonstrated in vitro against Caenorhabditis elegans for aqueous and 100% ethanol extracts of the dried aerial parts of South African plants, at concentrations of 1.0mg/ml. A hexane extract proved inactive at a concentration of 2.0mg/ml. The same study found water and ethanol extracts to be inactive in an in vitroassay for anti-amoebic activity.
Molluscicidal activity of 80% ethanolic extracts of dried leaf, stem and fruits of Sudanese plants against Biomphalaria pfeifferi and Bulinus truncatus could not be demonstrated in vitro (concentration 200mg/litre). Anticonvulsant activity of an aqueous extract of dried leaf has been demonstrated in vivo in the mouse (dose: 200.0mg/kg IP) . In an in vitro assay for antiphage activity of aqueous fresh leaf+stem extracts of Greek plants, no activity was demonstrated against Bacteriophages MS2, PHI-CHI-174, T-7, T2, T4 or Bacteriophage-OPS7 . Extracts of shade-dried roots of Ethiopian plants were examined for anti-fertility activity in the rat, both in vitro (uterine stimulant activity) and in vivo(anti-implantation effects). Weak uterine stimulant activity was shown for 95% ethanol extracts but not for aqueous or n-butanol extracts (conc. 2.0%). Anti-implantation activity was shown by both n-butanol nd (%% ethanolic axtracts but not by aqueous extracts (dose: 0,93g/kg intragastrically) .


[SIZE=-1]Brine shrimp lethality assay[/SIZE]
[SIZE=-1]preliminary results showed no effect on brine shrimps in the concentrations tested.[/SIZE]​

[SIZE=-1]Antibiotic activity assay[/SIZE]

[SIZE=-1]No in vitro antimicrobial activity was observed in preliminary assays, in the concentrations used.[/SIZE]​

Finally, it's said that the main alkaloid (the fuck is a alkaloid?)Leonurine is present in the plant and some variations, but this article says that's false essentially, and there's doubt about the alkaloid or whatever being present at all: https://www.ncbi.nlm.nih.gov/pubmed/23346757

My primary concern is if smoking or making a tea out of this herb can cause a reaction with food that is deadly. For example taking a MAO Inhibitor and then eating cheese for example. Or whatever food I'd like to shove in.
As in. Is this herb a MAO Inhibitor?
I did smoke about 3 cigarettes loaded with this stuff (it burns really fast so perhaps 50% of the smoke or more did not actually enter), and then ate kebab with vegetables, hot sauce and a sauce made out of diary together with ham.

I did not have any serious illness or effects, but I did notice a pain-ish pressure in my head just 5 minutes after finishing the meal. Lasted 8 minutes or so. Like a minor headache. But it could have been just a random headache not related.

My Secondary concern is if this can react badly with other things. Hawaiian Baby Woodrose for example, or tobacco.


Frumious Bandersnatch
Nov 3, 1999
Looking-Glass Land
From my own anecdotal personal experience it doesn't interact with LSA or tobacco. Or any foods that I know of.

I don't have any reason to believe it is an effective MAOI if indeed it is one (and I have no reason to believe it is when used orally). I have only made tea and smoked the stuff though. Very disgusting smoked, and I didn't get anything from smoking it or the tea. YMMV, but I don't think you have anything to worry about when it comes to LSA, tobacco or foods.

NOW please take with a grain of salt, as I only have very limited experience with this plant. It just happens I used it shortly after trying LSA (from morning glories). I regularly smoked tobacco when I took it, and that I feel more confident isn't an issue.

If it wasn't pleasant or became associated with undesireavle side effects, I'd suggest just avoiding it. That is a pretty good policy when it comes to drug use.