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Covid-19 Who's planning on getting a COVID-19 vaccine? (Poll)

Are you planning on getting a COVID-19 vaccine?

  • Yes, as soon as possible

  • Probably but I'm going to wait a while first and see how others tolerate it

  • Probably not but maybe

  • No, never


Results are only viewable after voting.

Xorkoth

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Since I'm at higher risk than most, and since I am in a band and am eager to get back out into the world, I am not going to wait and see, I'm gonna get it as soon as possible. If I was a homebody, I probably would wait (maybe anyway), but that is just not me at all (being a homebody I mean). All this staying apart from people is killing me and has been for almost a year now. Bring it on.
 

w01fg4ng

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I'm fortunate enough to afford the wait but I'm not innately immune or anything (in fact I'm probably quite presumptuous). I'll get it after seeing most of my friends and family get it, and much of that is out of my control but some will be mine as well.

Respect to everyone getting it asap.
 

G_Chem

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Just a heads up, and not saying this so people don’t get them..

I’ve been hearing lots of people having negative reactions to the second shot. (Moderna) Sounds like it’s temporary but something to consider. Lots of doctors and nurses calling in sick right now because of it.

-Gc
 

Gormur

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I'm one of those assholes who doesn't get sick from anything, so when I had all 5 of the standard vaccines at school; I went to a private school and they had people come out to give us the shots. I didn't get negative reactions or anything. I once had chickenpox but it didn't itch. I caught bronchitis as a kid which is the only thing that ever made me think I might die, since I was young when I caught it and doctors made me wait a month to get re-tested for it. Other than that I haven't been ill since

I'm against drugs that aren't recreational and I haven't had the flu vaccine either. I just think it's scaremongering, but that's my opinion after-all. I don't expect people to have an unusual immune system like me. I just hope airlines don't start requiring people to vaccinate themselves, since I plan to live abroad at some point
 
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JessFR

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Yes, as soon as I'm offered it. I had a massive sigh of relief when I saw the initial poll votes. I was concerned that more people would be against it simply because they don't trust the government.

The extremist conspiracy theorist types are loudmouths, they make it seem like they're the majority by being as loud as possible to everyone around them so it seems like their view is everywhere.

It's not, there's a much quieter majority that is the rest of us who just grit our teeth and try and restrain ourselves from punching them in the face. :D
 

chinup

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It may evolve into a super virulent nasty strain to evade current vaccines and those vaccinated with the current vaccines will have problems.
Isn't one of the great advantages of mRNA vaccines that they can be quickly refined in this scenario? Would there be any reason why people already vaccinated couldn't also receive the updated vaccine?

I don't really see why this would be more of an issue for SARS-COV2 than other RNA viruses like polio as under the same selection pressures (mutation obviously depends on how suited an organism is to its environment as a perfectly suited organism doesn't want to mutate and vice versa) their likelihood of developing problematic mutations should be similar. I take it this particular issue is due to the type of vaccine?

Alternatively coronavirus will evolve into something more benign, in which case who cares if you collide with it vaccinated or not.
This is most likely but is still a long way off. Viruses are unlikely to increase their pathogenicity over time because natural selection favours keeping hosts alive and in sufficiently good health to spread it. Virulence is obviously highly selected for.
 

dalpat077

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Isn't one of the great advantages of mRNA vaccines that they can be quickly refined in this scenario? Would there be any reason why people already vaccinated couldn't also receive the updated vaccine?
I'm certainly no expert at all but as I understand it: you're right about the mRNA vaccines (although hoping one of our resident experts will confirm or explain better).

Problem that I see though: if the above be the case I'd reckon the problem would not be so much the refining or tinkering so much as actually getting it out there in order to sort of outrun it (the already mutated virus I mean). Dunno.
 

MsDiz

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I'm certainly no expert at all but as I understand it: you're right about the mRNA vaccines (although hoping one of our resident experts will confirm or explain better).

Problem that I see though: if the above be the case I'd reckon the problem would not be so much the refining or tinkering so much as actually getting it out there in order to sort of outrun it (the already mutated virus I mean). Dunno.
Exactly right, mutations will occur, it’s outrunning them is the issue.

I’ve had both my Pfizer shots now.

I have been ill as fuck but it’s due to my low weight and not the vaccine. I’ll survive covid but every other fucking infection is coming for my ass.
 

dalpat077

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Exactly right, mutations will occur, it’s outrunning them is the issue.

I’ve had both my Pfizer shots now.

I have been ill as fuck but it’s due to my low weight and not the vaccine. I’ll survive covid but every other fucking infection is coming for my ass.
I'm sorry to hear about your being ill. Obviously and that goes without saying. ❤️

If it'll make you feel a bit better though: just think that every Pfizer jab goes toward keeping the cost of legit Xanax stable! 🤣

Must say I do like their new logo though too. Always been a big fan though. Something about the name? Dunno. And this in spite of all of the overdue commission checks (cheques) still (apparently) in the mail. 🤣
 
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cduggles

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I also posted this in the big COVID thread:
Great resource article that won’t paste in full for some reason:
How The COVID-19 Vaccines Compare To Each Other
Experts break down the Moderna, Pfizer, Novavax, Johnson & Johnson and AstraZeneca coronavirus shots, including efficacy, storage needs and more.
 

novaveritas

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Isn't one of the great advantages of mRNA vaccines that they can be quickly refined in this scenario? Would there be any reason why people already vaccinated couldn't also receive the updated vaccine?
The vaccine payload can be modified, the question is can the immune system of people who are already vaccinated with an older vaccine be modified successfully with an updated vaccine using the same mRNA platform? or will the upgrade brick the system?

That is something nobody knows at this point, hence hedging and waiting to see. I have thought about it quite a bit and can see some pitfalls and don't know any answers either.

Modified improved vaccines, Someone who has been vaccinated with a narrow antigen such as the spike produced by the mRNA vaccines has antibodies to the original spike in the original vaccine. These antibodies will bind to the modified spike in the "new improved upgrade vaccine" (TM), not all of them or as maybe not as well, but they will bind sufficiently and the B cells that make these sub-par antibodies will be stimulated to make more and more of the original antibodies. If these are reasonably effective, then they lead to clearing the new improved spike (vaccine antigen) quickly before there is time for much selection. Perversely existing antibodies prevent the immune system from developing the new improved antibodies, reducing the ability to adapt, causing failure of the service pack upgrade to install. That is the concept of original antigenic sin. It was seen in 2009 with people who had the normal flu shot not producing very good antibodies to the pandemic H1N1 vaccine and in many other situations. They were good enough to bind the vaccine antigen but the vaccine is not the virus, at least some antibodies to a real live virus need to be neutralizing or they can be worse than useless (ADE and similar).

mRNA vaccines only produce spike for a short time and is self clearing through the liver I guess, perhaps a week at the outside but more likely a couple of days, (hey Pfizer Moderna where is this really basic data???) because the mRNA vaccine is self clearing there is no need for antibodies to be neutralizing, they just have to stick pretty well, so there is no selection for neutralizing antibodies over high affinity antibodies.

there are some other issues too, where nobody has any answers.
The transport lipids used in the mRNA vaccines appear to be immunogenic themselves, so reactive and potentially anaphalactic type reactions and other reactions to the vaccine delivery packaging is then likely to become more common. Anaphalactic type reactions are already much higher with both Pfizer and Moderna than any previous vaccine ever deployed and dose 2 is more problematic than dose 1, dose 3 of an upgrade would likely be even worse. I would be surprised based on the current data if the mRNA vaccine platforms get regular product licenses rather than just the limited pandemic emergency use approval they have now but we are truly in a brave new world where anything goes.

The viral vector vaccines can be adapted practically as fast as the mRNA ones but they have an additional problem, immunity builds against the viral vector usually an adenovirus which makes them less and less effective on repeat dosing the immune system just wipes out the vector virus, this has already been seen with AZ Oxford vaccine and will also be an issue with J&J. Sputnik uses 2 different adenoviruses for the 2 doses so has a slight advantage but they don't seem to be able to culture both adenoviruses efficently. So again there are pitfalls.

This is an aside, but coronavirus vaccines are not comparable to polio vaccines. Polio vaccine is complete inactivated or live attenuated virus, therefore people vaccinated have a broad range of antibodies to many parts of the virus, for the virus to escape all of those antibodies would be quite a feat of evolution even though polio mutates at quite a high rate. This is in contrast to single antigen coronavirus vaccines where only a small part of spike has to evolve to evade the current vaccines.

The immune system is stupidly and beautifully complex and the level of knowledge and understanding about it is highly incomplete, but that is not the story immunologists and people selling vaccines want to tell anyone. It is a minefield.
 

cduggles

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I posted this in the main COVID thread as well. It’s a link to an article about the different vaccines.

Great resource article that won’t paste in full for some reason:
How The COVID-19 Vaccines Compare To Each Other
Experts break down the Moderna, Pfizer, Novavax, Johnson & Johnson and AstraZeneca coronavirus shots, including efficacy, storage needs and more.
 

QTpi

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Getting Pfizer today.

This mask is nice and warm though. Hopefully it comes off by summer time.
 

QTpi

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You're getting the vaccine today? How are you qualifying so soon??

I live in a house ran by the department of mental health. It's 24 hour double staffed. Staff got it last week since they're essential. I think they're trying to control the situation.
 

6am-64-14m

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SO is talking about the vaccine and they dose it local in a few places so waiting on her final answer before pushing the button.
I like using that phrase:
Don't make me push the button!
 

Xorkoth

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I live in a house ran by the department of mental health. It's 24 hour double staffed. Staff got it last week since they're essential. I think they're trying to control the situation.

Lucky. I can't wait to get it. My band is doing as much as we can, meaning we are doing some outdoor shows. Biggest problem is that some of them are not at all careful and are constantly hanging out with friends and going to parties and stuff, and I practice with them in close quarters. Since finding out I am at higher risk of serious disease, I have been more sketched out about getting it.

Besides that, I just really want to get back to going on the road and playing a lot of shows, though it will take most people getting vaccinated before places will return to normal in that area.
 
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