Casual.dream,
Have you done a genetic test to see if you might carry the mutations that cause Bartter syndrome or Gitelman syndrome? They are both rare renal disorders and might not be the first thing a doctor would consider but some of your symptoms indicate the possibility, particularly if you've noticed urinary issues most of your life. I am only heterozygous for Bartter but have had electrolyte imbalances (potassium-wasting & salt-wasting), weakness/fatigue, dehydration, and polyuria (peeing too much) for my first 20 or so years of life...all have improved in the decades since and I'm now symptom-free, but I'm not sure how. I didn't know about it until recently so I never received treatment.
The mutation affects the Na-K-2Cl cotransporter NKCC2. NKCC2 facilitates ∼20–25% of the reuptake of the total filtered NaCl load. [NaCl = sodium chloride = salt]
As for the phenibut affecting your urine, phenibut acts as an agonist of GABA receptors...These receptors upregulate the expression of the chloride exporter KCC2, while also downregulating NKCC1. What does that all mean? Unfortunately, I have no idea. It would take a smarter person with more scientific knowledge than me to properly interpret what all this means. All I can figure out is there's some kind of effect on electrolytes.
