Misc What is the most addicting drug in the world???
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sekio
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It depends on a lot of things. Could you reprase the question?
The drug most likely to form physical dependence?
The drug most likely to form psychological dependence?
The drug most likely to cause troublesome withdrawal effects?
Maybe the drug most likely to cause repeated self administration ("moreishness")?
Are you asking if there is a drug that 'instantly causes addiction', like the old bogeyman story, 'one hit and you're hooked for life'?
An important thing to consider is that everyone, on a personal and individual level, has different predispositions for what substances and experiences they find pleasurable. There are people who like stimulants, people who like opioids, people who like dissociatives etc. So while one person may find cocaine is the most addictive drug, another person could disagree entirely, because they prefer opioids and find that they have no desire to use cocaine.
Caffeine, nicotine, tetrahydrocannabinol, barbiturates, opium-based-painkillers, and amphetamines are all contenders.
The drug most likely to form physical dependence?
The drug most likely to form psychological dependence?
The drug most likely to cause troublesome withdrawal effects?
Maybe the drug most likely to cause repeated self administration ("moreishness")?
Are you asking if there is a drug that 'instantly causes addiction', like the old bogeyman story, 'one hit and you're hooked for life'?
An important thing to consider is that everyone, on a personal and individual level, has different predispositions for what substances and experiences they find pleasurable. There are people who like stimulants, people who like opioids, people who like dissociatives etc. So while one person may find cocaine is the most addictive drug, another person could disagree entirely, because they prefer opioids and find that they have no desire to use cocaine.
Caffeine, nicotine, tetrahydrocannabinol, barbiturates, opium-based-painkillers, and amphetamines are all contenders.
tricomb
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Research over the years has repeatedly shown Nicotine win the most addictive drug title over and over again. Also hotly debated is heroin and cocaine. Here are some articles and their findings.
http://www.ncbi.nlm.nih.gov/pubmed/1734519
The following article argues that cocaine might just barely be more addicting than nicotine but that price and environmental factors such as the ease of access to tobacco/nicotine over the average typical access to cocaine etc. This is the first literature I've seen that rated a drug as more addicting than Nicotine. http://www.ncbi.nlm.nih.gov/pubmed/1859920
This is the chart I've seen cited by authorities I trust many times:
http://www.ncbi.nlm.nih.gov/pubmed/1734519
The following article argues that cocaine might just barely be more addicting than nicotine but that price and environmental factors such as the ease of access to tobacco/nicotine over the average typical access to cocaine etc. This is the first literature I've seen that rated a drug as more addicting than Nicotine. http://www.ncbi.nlm.nih.gov/pubmed/1859920
This is the chart I've seen cited by authorities I trust many times:
like sekio wrote, it all depends on the individual. for those that are prone tho:
from a numbers standpoint, alcohol, caffeine, or tobacco.
from a fiendish standpoint, crack or dilaudid
from a destructive standpoint, meth or heroin
from an instant 'wanna do it again' standpoint, whippits/other inhalants. This last one isnt most people's thing, but for those that do it, holy shit.
LSD is almost anti-addictive in that, for me anyway, even an AWESOME trip (of which Ive had many) isnt something you want to repeat the next day. Ecstasy is also too much a body load to do day in/out, and is one of the few drugs of which I agree with its position in the above chart.
from a numbers standpoint, alcohol, caffeine, or tobacco.
from a fiendish standpoint, crack or dilaudid
from a destructive standpoint, meth or heroin
from an instant 'wanna do it again' standpoint, whippits/other inhalants. This last one isnt most people's thing, but for those that do it, holy shit.
LSD is almost anti-addictive in that, for me anyway, even an AWESOME trip (of which Ive had many) isnt something you want to repeat the next day. Ecstasy is also too much a body load to do day in/out, and is one of the few drugs of which I agree with its position in the above chart.
daytryptr
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Ghb less addictive than cannabis?
I don't think so.... At least In terms of wds ghb is far, far more dependence causing than cannabis.
I've seen that graph before and don't really agree with it, did they factor in how much of a variance there is in the number of people using said drugs?
If not, that's the only way it makes sense to me. Less ghb users than cannabis, hence more cannabis "addicts" than ghb addicts, whatever they define an addict as, but to say a gabergic like ghb causes less dependence thanncannabis doesn't make any kind of sense.
I don't think so.... At least In terms of wds ghb is far, far more dependence causing than cannabis.
I've seen that graph before and don't really agree with it, did they factor in how much of a variance there is in the number of people using said drugs?
If not, that's the only way it makes sense to me. Less ghb users than cannabis, hence more cannabis "addicts" than ghb addicts, whatever they define an addict as, but to say a gabergic like ghb causes less dependence thanncannabis doesn't make any kind of sense.
infectedmushroom
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timetohunt
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While the question of the OP can't really be answered at face value here would be a good try.....
ETONITAZENE
It has been suggested that etonitazene is the most addictive substance on the planet. As an opioid, it exhibits 1,500 times the potency of morphine, but it’s also a stimulant on par with ecstasy. Basically, it’s a molecular speedball. Although etonitazene has appeared as a street drug on a few occasions, the vast majority of the world’s supply is consumed by mice and monkeys in addiction studies. Scientists know that rhesus monkeys lick their little furry lips with delight when you spike their water dish with etonitazene, but monkeys like a lot of shit, and as the old saying goes, never send a rhesus monkey to do a man’s job.
Thomas Highsmith worked at a prestigious laboratory in Salt Lake City designing low-friction laminates for high-performance skis. In 2003, he started spending long nights in his lab secretly manufacturing a personal supply of etonitazene. Shortly after completing the synthesis, he became hopelessly addicted. He would show up for work clutching a 12-ounce spray bottle of etonitazene and fiendishly snort it throughout the day. Over the course of a couple of months, his tolerance escalated to the point where he was taking 300 times his starting dose. A coworker became suspicious of Highsmith’s odd behavior and reported him to the police. His etonitazene supply was seized, and he was prescribed methadone to combat the withdrawal. At that point, his addiction equated to 500 bags of heroin a day, and the methadone umbrella did nothing to deflect the 10,000-pound etonitazene anvil hurtling toward his head. Highsmith never received a criminal sentence because he was found dead in his home before his first court date. The withdrawals were so severe that he had killed himself to escape the pain.
Credit for this goes to Hamilton's Pharmacopia Vice Magazine Apr 2 , 2009. If you're interested in fascinating Drug news and mini-documentaries Hamilton's Pharmacopia will not disappoint.
ETONITAZENE
It has been suggested that etonitazene is the most addictive substance on the planet. As an opioid, it exhibits 1,500 times the potency of morphine, but it’s also a stimulant on par with ecstasy. Basically, it’s a molecular speedball. Although etonitazene has appeared as a street drug on a few occasions, the vast majority of the world’s supply is consumed by mice and monkeys in addiction studies. Scientists know that rhesus monkeys lick their little furry lips with delight when you spike their water dish with etonitazene, but monkeys like a lot of shit, and as the old saying goes, never send a rhesus monkey to do a man’s job.
Thomas Highsmith worked at a prestigious laboratory in Salt Lake City designing low-friction laminates for high-performance skis. In 2003, he started spending long nights in his lab secretly manufacturing a personal supply of etonitazene. Shortly after completing the synthesis, he became hopelessly addicted. He would show up for work clutching a 12-ounce spray bottle of etonitazene and fiendishly snort it throughout the day. Over the course of a couple of months, his tolerance escalated to the point where he was taking 300 times his starting dose. A coworker became suspicious of Highsmith’s odd behavior and reported him to the police. His etonitazene supply was seized, and he was prescribed methadone to combat the withdrawal. At that point, his addiction equated to 500 bags of heroin a day, and the methadone umbrella did nothing to deflect the 10,000-pound etonitazene anvil hurtling toward his head. Highsmith never received a criminal sentence because he was found dead in his home before his first court date. The withdrawals were so severe that he had killed himself to escape the pain.
Credit for this goes to Hamilton's Pharmacopia Vice Magazine Apr 2 , 2009. If you're interested in fascinating Drug news and mini-documentaries Hamilton's Pharmacopia will not disappoint.
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timetohunt
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Also culled from Vice's Hamilton's Pharmacopia April 2, 2009, this may be Numero Uno, provided it actually existed. I personally believe the story, as I was following some of the associated posts when this was all going down. Nothing seemed made up at all.
PHARAOH FENTANYL
Etonitazene is hardly the most potent opioid known to man. Another class of opioids called the fentanyls is routinely much stronger. A classic example is carfentanyl, which is 7,000 times more potent than morphine. Carfentanyl was famously used to anesthetize a Tyrannosaurus rex in Jurassic Park 3, but it’s actually a real drug used to knock out bears and rhinos. Fentanyls have historically been a popular choice for naughty chemists because just a few grams can be cut and sold as thousands of bags of “heroin” at a tremendous profit, but this ruse has resulted in the deaths of hundreds of junkies who have overdosed on improperly cut fentanyl. Thus, fentanyl chemists are considered the slimiest scum of the drug-synthesis underworld. They make meth cooks look like hospice nurses. A junkie friend of mine said that he would not hesitate a moment before turning a fentanyl chemist in to the police.
Two years ago, a young Canadian guy made a post on an internet drug forum begging for help withdrawing from an unknown opioid he called pharaohfentanyl, a synthesis of a new fentanyl derivative that he claimed to be 4,000 times more potent than morphine—the strongest opioid a human had ever tasted. He was generally mocked and assumed to be a liar, but after asking around a bit, I’ve come to the conclusion that his story was probably true. Although his original intention had been to deal the drug on blotter paper, he started using and spent the next six months on a nonstop pharaohfentanyl binge. His dosage increased 675-fold, and by the end he was using amounts that would equate to 3,300 bags of heroin a day. His breath alone was strong enough to make someone nod. He destroyed his entire supply and quit cold turkey. Here is how he described the withdrawal: “I cannot feel my FACE! It’s like touching a brick wall. It feels like I took a bath in MENTHOL, my insides feel like ice… that will shift after a few seconds to MENOPAUSE-ESQUE INSANE hot flash like a wave of lava under my skin with profuse sweating… I’M SOOO WEAK AND SOOO TIRED AND SOOO DRAINED I JUST WANT IT TO GO AWAY RIGHT NOW!”
The general consensus is that if you’re smart enough to be making designer opioids, you should be using your skill to make LSD or a similar tool for enlightenment, but the temptation is hard to beat. I called up a chemist friend in England who has dabbled in the field. He said, “I’ve accumulated a shitload of data on designer opiates, but hopefully it will never see the light of day. I truly don’t want to encourage people to make these things that are effectively in the realm of psychochemical weapons, but they are so damn interesting that sometimes my judgment goes out the window and I start to chunter on about potential routes of synthesis and… oh well, sometimes I wish I could just shut the fuck up.”
But guess what? Pharaohfentanyl is still not the most potent opioid ever discovered. The strongest painkiller in the world has only an abbreviated chemical name, 4-F-Ohmefentanyl, and it has 18,000 times the potency of morphine. After that, there is very little room left for improvement. It’s the hydrogen bomb of painkillers, and as far as I can tell, no human has ever tasted it. A suitcase full of this stuff could cure all the pain on Earth, which is sort of a pleasant thought. I tried contacting the Chinese chemists who discovered it but got no reply. I assume that either they don’t speak English or they aren’t willing to discuss their invention with the press. Or maybe, just maybe, their curiosity has already gotten the best of them.
PHARAOH FENTANYL
Etonitazene is hardly the most potent opioid known to man. Another class of opioids called the fentanyls is routinely much stronger. A classic example is carfentanyl, which is 7,000 times more potent than morphine. Carfentanyl was famously used to anesthetize a Tyrannosaurus rex in Jurassic Park 3, but it’s actually a real drug used to knock out bears and rhinos. Fentanyls have historically been a popular choice for naughty chemists because just a few grams can be cut and sold as thousands of bags of “heroin” at a tremendous profit, but this ruse has resulted in the deaths of hundreds of junkies who have overdosed on improperly cut fentanyl. Thus, fentanyl chemists are considered the slimiest scum of the drug-synthesis underworld. They make meth cooks look like hospice nurses. A junkie friend of mine said that he would not hesitate a moment before turning a fentanyl chemist in to the police.
Two years ago, a young Canadian guy made a post on an internet drug forum begging for help withdrawing from an unknown opioid he called pharaohfentanyl, a synthesis of a new fentanyl derivative that he claimed to be 4,000 times more potent than morphine—the strongest opioid a human had ever tasted. He was generally mocked and assumed to be a liar, but after asking around a bit, I’ve come to the conclusion that his story was probably true. Although his original intention had been to deal the drug on blotter paper, he started using and spent the next six months on a nonstop pharaohfentanyl binge. His dosage increased 675-fold, and by the end he was using amounts that would equate to 3,300 bags of heroin a day. His breath alone was strong enough to make someone nod. He destroyed his entire supply and quit cold turkey. Here is how he described the withdrawal: “I cannot feel my FACE! It’s like touching a brick wall. It feels like I took a bath in MENTHOL, my insides feel like ice… that will shift after a few seconds to MENOPAUSE-ESQUE INSANE hot flash like a wave of lava under my skin with profuse sweating… I’M SOOO WEAK AND SOOO TIRED AND SOOO DRAINED I JUST WANT IT TO GO AWAY RIGHT NOW!”
The general consensus is that if you’re smart enough to be making designer opioids, you should be using your skill to make LSD or a similar tool for enlightenment, but the temptation is hard to beat. I called up a chemist friend in England who has dabbled in the field. He said, “I’ve accumulated a shitload of data on designer opiates, but hopefully it will never see the light of day. I truly don’t want to encourage people to make these things that are effectively in the realm of psychochemical weapons, but they are so damn interesting that sometimes my judgment goes out the window and I start to chunter on about potential routes of synthesis and… oh well, sometimes I wish I could just shut the fuck up.”
But guess what? Pharaohfentanyl is still not the most potent opioid ever discovered. The strongest painkiller in the world has only an abbreviated chemical name, 4-F-Ohmefentanyl, and it has 18,000 times the potency of morphine. After that, there is very little room left for improvement. It’s the hydrogen bomb of painkillers, and as far as I can tell, no human has ever tasted it. A suitcase full of this stuff could cure all the pain on Earth, which is sort of a pleasant thought. I tried contacting the Chinese chemists who discovered it but got no reply. I assume that either they don’t speak English or they aren’t willing to discuss their invention with the press. Or maybe, just maybe, their curiosity has already gotten the best of them.
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tricomb
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^Interesting input given the speculative nature of this thread.
I don't think that necessarily most extremely potent opioids are guaranteed to produce desirable effects like euphoria, usually there's a fuckload of sedation that can get really scary w/ respiratory depression, especially in the fentanyl analogues and other Bentley compounds.
4-Methylaminorex IMO should be up there on the most addicting list ha, in my experience definitely. Way moreso than with fentanyl or fentanyl analogues or other insanely potent synthetic opioids. Just my $0.02.
But that's why this thread will never work and why I will close it right now, just because I think something is the most addictive, doesn't mean that I'll have many or any others who agree with me out of speculation and experience which varies individual to individual and therefore this question cannot really be answered in a general sense. Everyone is wired different and IMO every person is more likely to uniquely be susceptible to become addicted to Drug "ABC", while random person #2 might not face addiction issues if they used "ABC", but when person #2 uses ABC, they can't control their use in a manner that random person #1 doesn't express.
I don't think that necessarily most extremely potent opioids are guaranteed to produce desirable effects like euphoria, usually there's a fuckload of sedation that can get really scary w/ respiratory depression, especially in the fentanyl analogues and other Bentley compounds.
4-Methylaminorex IMO should be up there on the most addicting list ha, in my experience definitely. Way moreso than with fentanyl or fentanyl analogues or other insanely potent synthetic opioids. Just my $0.02.
But that's why this thread will never work and why I will close it right now, just because I think something is the most addictive, doesn't mean that I'll have many or any others who agree with me out of speculation and experience which varies individual to individual and therefore this question cannot really be answered in a general sense. Everyone is wired different and IMO every person is more likely to uniquely be susceptible to become addicted to Drug "ABC", while random person #2 might not face addiction issues if they used "ABC", but when person #2 uses ABC, they can't control their use in a manner that random person #1 doesn't express.
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