Opioids what drugs can i abuse whilst on olanzapine (antipsychotic)

[jaurk]

I'm on codeine at the moment and although olanzapine isn't a opiod antagonist i still feel no euphoria or sedation.
perhaps it cascades to dopamine and is then blocked?

I'm starting to think gabaergics (ghb, benzos) are my only option.
and of course weed, but i don't smoke.




5-HT1A 2,063–2,720 Antagonist
5-HT1B 509–660 ND
5-HT1D 540–1,582 ND
5-HT1E 2,010–2,408 ND
5-HT1F 310 ND [69]
5-HT2A 1.32–24.2 Inverse agonist
5-HT2B 11.8–12.0 Inverse agonist
5-HT2C 6.4–29 Inverse agonist
5-HT3 202 Antagonist
5-HT5A 1,212 ND
5-HT6 6.0–42 Antagonist
5-HT7 105–365 Antagonist
?1A 109–115 Antagonist
?1B 263 Antagonist
?2A 192–470 Antagonist
?2B 82–180 Antagonist
?2C 29–210 Antagonist
?1 >10,000 ND
?2 >10,000 ND
D1 35–118 Antagonist
D2 3.00–106 Antagonist
D2L 31–38 Antagonis
D2S 21–52 Antagonist
D3 7.8–91 Antagonist
D4 1.6–50 Antagonist
D4.2 17–102 Antagonis
D4.4 21–60 Antagonist
D5 74–90 Antagonist
H1 0.65–4.9 Inverse agonist
H2 44 Antagonist
H3 3,713 Antagonist
H4 >10,000 Antagonist
M1 2.5–73 Antagonist
M2 48–622 Antagonist
M3 13–126 Antagonist
M4 10–350 Antagonist
M5 6.0–82 Antagonist
?1 >5,000 ND
?2 ND ND ND
Opioid >10,000 ND
nACh >10,000 ND
NMDA
(PCP) >10,000 ND
SERT ?3,676 ND
NET >10,000 ND
DAT >10,000 ND
VDCC >10,000 ND
VGSC >5,000 ND
hERG 6,013 Blocker

 

[Scrofula]

Can't tell you to abuse drugs, OP, or which ones to take. Something about ethics, maybe keeping harm from the abuse of drugs to a minimum. And to quiet the banshee cries of moralist pearl-clutchers.

So that's the first problem. The next is that you're currently taking olanzapine/Zyprexa, which is used for treating some serious mental health problems. Serious disorders of the mind are too serious to combine with drugs that disorder the mind. IOW, no one has a clue how our minds work even when they're "healthy", there's definitely no way to safely predict how a divergent mind will respond to an abused drug.

Another problem is that if you're being treated for a serious mental illness, I just have to believe you're also prescribed meds you didn't mention. That would be important to know. Your psychiatrist would also really appreciate knowing exactly what might be flowing through your brain, so keep her informed of your experiments, even if it really pisses her off. She's trying to treat you, use her as the resource someone is paying a lot for.

The big problem if we ignored all those others: olanzapine has a lot of brain targets (and thanks for including that chart, please tell your friends to make that a tradition) and even the ones that it doesn't appear to notice may be affected through feedback and cross talk. It's messy, and there are caveats to the significance of those numbers.

Now, with my authority based on countless nights (since April) of misinterpreting those tables, I notice a few things. One, it really knocks out histamine. This drug should put everyone to sleep on the first dose. I'm sure you develop tolerance, but the anti-histamine action alone makes me think you would want to avoid downers like gabaergics and opioids.

It also really slams your muscarinic acetylcholine receptors (M1-5). That antagonism causes some trippy effects, like the slowing of time, hallucinations, and memory impairment. Dries out your mouth and eyes. The memory issues should preclude you from using gabaergics, especially benzos. That combination would be very dangerous if it led to blackouts.

It's also a moderate alpha blocker, which again, would be sedating. So another reason to avoid sedative drugs.

The two main characters are the dopamine 2r and the serotonin 2a; both experience reduced activity. These two are probably the cause of your desire for recreational drugs. Together they seem to really blunt the fun in life. We have a megathread here for users of invega sustena, link a different drug that has the same mechanism of action. Users there really don't seem to like the loss of vibrancy and imagination that come with the drug, along with a reduced ability to feel pleasure. When I feel a bit like that, it's usually a good idea to hide the booze (from me). Consider that dopamine is involved in reward, D2 overaction in vivid delusions, and activation of the HT2a receptor is what gives psychedelics some of their more imaginative character. Olanzapine does the opposite of these things.

Now remember that dopamine systems are THE target for a lot of abused drugs; but you have a drug present that would oppose them. So even stimulants should be avoided, if they'd be very effective anyway. They'd definitely interfere with your treatment. Another drug class targets serotonin systems, mainly psychedelics like LSD and club drugs like MDMA. And you're taking a drug that works in opposition. The combination would be unhelpful at best, and potentially dangerous.

But remember, a drug with this downside would only be given to those who need it, because it really does not sound fun. But that means you have some major treatment and therapy underway. You may be as desperate as this drug allows for some kind of sensation or warmth, but there really isn't anything that could provide it, and you don't want to risk your therapy (or life). Look at it as each day of therapy that concludes successfully, is a day closer to the one where you get off this drug.

 

[Scrofula]

Oh, there is always nicotine. Doesn't directly cause a problem. I did hear you say you are of the age to buy tobacco products where ever it is you are, and that with diminished dopamine activation, you wouldn't abuse it. So loopholes traversed.

Although I would bet you either already are a heavy smoker, or you're somewhere that doesn't allow it, in which case you're covered in patches as we speak. Well, it's a thought anyway.

The post above, of course, was written by a random guy on the internet with no credentials or training in any of the material. At least one statement will be wrong, just probabilistically. The takeaway is not to abuse any drugs while on psych meds.

 

[Båtmannen]

Opioids, bensodiazepines and GABA-drugs (benzos and gabapentin/lyrica, for example) shouldn't be blocked by it. Codeine, though, is not a very potent opiate, but that's only good.

If there's Paracetamol in it, use a CWE.

For a cheaper (if you have some sort of insurance), and safer high, ask your doctor for trihexyphenidyl or Biperiden, for RLS or tense muscles. Some really like it. Pros: you won't go to jail, it's probably cheaper and it won't turn up on drug screening. Cons: you may not like it, your vision will be blurred, you won't study or work effectively on it, you will experience significant cognitive inhibition (losing words, forgetting what to say in the middle of a sentene, etc).

I disliked the physical effects, and it made my OCD terrible (during the high), but it relieved my anxiety effectively, induced a not very strong but noticeable raise in mood, and was a good sleeping aid. One of the guys I was locked up with, liked it enough to exchange a pill trihexiphendiyl for a few mgs of buprenorphine, and another compared it to MDMA. While someone on my current place took one pill once and "never again".

Worth a shot, and better than risking ODs by switching to heavier opiates.

 

[Båtmannen]

So that's the first problem. The next is that you're currently taking olanzapine/Zyprexa, which is used for treating some serious mental health problems. Serious disorders of the mind are too serious to combine with drugs that disorder the mind..

In many cases, yes, but it could be just for a sleeping aid, which - unfortunately (my own idea)seems to be the case just as often as it's described for psychosis. I know it's used for mood stabilzing as well, and for the prevention of mania, but it's a heavy medication with alot of side effects, but since it wont get people high doctors like it.

 

[treezy z]

Olanzapine makes drugs work much worse. I was on it, weight gain made me throw the pills away.

Weed dissociative stimulants work with much less euphoria.

Opiates benzos booze work but on top of olanzapine sedation will lay you out.

Classic psychedelics (serotonin agonists) and empathogens won't do anything the receptors are blocked.

Overall it makes drugs suck, I used them to deal with side effects though. Horrible medication.

I find a low dose Seroquel regularly (50-100mg) and abilify when getting crazy much better, do what works for you though.

 

[Scrofula]

A lot anti-psychotic drugs have coincidental strong anti-histamine properties. Olanzapine should knock out an insomniac elephant. And I think hydroxyzine is prescribed more often now for sleep than psychoses. Now, since these multi-brain target psychiatric medications have the same sleep-inducing mechanism as any other anti-histamine, why a doctor, and more so a patient, would select them over OTC Benadryl, is totally beyond my non-licensed mind. That some people take drugs specifically to get to sleep, and are willing to sacrifice living in a world outside of gray-scale, I find only a little less strange. But then, I am a meth user. We choose sleepless color over teeth.

OP is entitled to BL HIPAA protections, and while he may just be using this as a sleep-aid, it's fair to give him the pamphlet for common indications, ie., thought disorders like schizophrenia and bipolar. But the same is true for "milder" psych meds, like the frequent college kid here wanting to know how many days he needs to wash out his antidepressants before rolling on MDMA, failing to realize a week off and a week on interspersed with massive receptor shocks, twice a month, might be worse for their underlying conditions than no treatment at all. They then continue to consume precious mental health resources that shiftless MediCal-receiving internet mods might use.

And then olanzapine has enough targets that whatever the reason for use, you might consider being on it to be a mental health issue on its own, and not to be combined recreationally. A lot of these meds take a fair amount of time to equilibrate across all those brain back channels, through up and down regulations and means not yet known.

****

Batmannen, I don't think the trihex or Biperiden will help much, since OP's med has nearly unplugged all his muscarinic receptors already. He might be inured to blurry vision and or open-eyed hallucinations. The passage of time, he now sees was an illusion to begin with.

After that, I don't like the idea of gabergics or opiates, because of extra-extra sedation, and anti-cholinergics plus benzos sound like instant blackout.

But then, that's my barely educated guess put forth as opinion.

 

[jaurk]

Thank you all.

Prescribed for schizoaffective after a second psychosis, I'm legally required to take this now and just wondered if anyone out there had any unique drug ideas.

Codeine I found worked however had significantly reduced buzz, but overall felt to be the most abusable. I enjoyed socialising compared to previous abuse where I'd get really drowsy and relaxed.

Psychedelics (LSD) just give me pyramidal effects. Discomfort.

Dissociative (DXM) DID work, and cause mental disconnection, but it was hollow and like sitting in an unpainted room, with grey walls and nothing nice.

Stimulants (dexamphetamine) kinda worked but I had to triple the dosage. It wasn't as "wow I'm on the edge of my seat and I've forgotten time passing", but I persisted with ideas and thoughts for longer still. Just less rushy.

Pregablin/lyrica caused all of the expected symptoms, a confusing wash of anxiolytic feeling, forgetting words and complete loss of coordination.

Benzos feel just as relaxing and calming as ever, when prerequisite stess exists.


Alcohol seems fine, perhaps a little less euphoric but I'm being subtle and picky there.

Cigarettes are good.

Anyway maybe adding my experiences would give this thread a little more substance

 

[treezy z]

jaurk I've been court ordered to take meds as well (several years ago) fucking hated it.

 

[Steady Scootin]

Court orders suck, been there myself. I'm also diagnosed as Schizoaffective, or was some years ago. Who really knows, especially with the recent changes to the DSM, which I was taking a gander at the other night. Pretty sure I've been prescribed Zyprexa, but not for sure, have run the gamut of neuroleptic medication over the years. My track record with them is horrible, but not due to any illicit drug use, as I have always been clean stuff these times. The older, "typical" antipsychotics work well, but those harsh side effects have me saying no thank you pretty quickly. The nee atypical meds may as well be a super expensive sweet tart, but hey! No side effects! Frustrating to put it mildly, and boy have I been fortunate in the doctor game, too. Often left wondering who needs the meds more, or when does being completely senile become a big enough issue before a given practice has to shut the doors. Oh, and my favorite, the "I'm quite obviously involved in unethical, highly illegal activity that stuffs these pockets, baby! Don't breathe near my Tesla on your way out, and here's a coupon for the pills that pay mah bills!!*

 

[Slow_Mobius]

Thank you all.

Prescribed for schizoaffective after a second psychosis, I'm legally required to take this now and just wondered if anyone out there had any unique drug ideas.

Codeine I found worked however had significantly reduced buzz, but overall felt to be the most abusable. I enjoyed socialising compared to previous abuse where I'd get really drowsy and relaxed.

Psychedelics (LSD) just give me pyramidal effects. Discomfort.

Dissociative (DXM) DID work, and cause mental disconnection, but it was hollow and like sitting in an unpainted room, with grey walls and nothing nice.

Stimulants (dexamphetamine) kinda worked but I had to triple the dosage. It wasn't as "wow I'm on the edge of my seat and I've forgotten time passing", but I persisted with ideas and thoughts for longer still. Just less rushy.

Pregablin/lyrica caused all of the expected symptoms, a confusing wash of anxiolytic feeling, forgetting words and complete loss of coordination.

Benzos feel just as relaxing and calming as ever, when prerequisite stess exists.


Alcohol seems fine, perhaps a little less euphoric but I'm being subtle and picky there.

Cigarettes are good.

Anyway maybe adding my experiences would give this thread a little more substance

I think you just answered your own question here. Unfortunately, we don't allow 'what should I take' threads and we're really focused on harm reduction--not helping people get high.

If you have a specific HR question, feel free to create a new post in this forum, but I don't think this is an HR discussion/question anymore.

Closed