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Misc What does a Wellbutrin high feel like

This is my experience with a ER Wellbutrin (e-HL 20 +/- 5 h) high. Because of the pandemic I was unable to get a better upper so I used what I had.

5'7 115 lb 21 yo F

hx: (unipolar) major depressive dx, panic dx, hereditary spherocytosis

rx: fluoxetine (prozac, SSRI) 40mg o.d. AM cc

dosage: 300 mg on sunday 8/23 AM, 300 mg on monday 8/24 AM, 300 mg on tuesday 8/25 AM, 150 mg on wednesday 8/26 AM

why: 1) exam week of 7 week (typically 16 week) condensed (COVID-19) semester with 15 credits of pre-health courses
a) in-person/mixed A&P II- Lecture exam Monday, Lab exam Thursday, Homework worksheet due Friday
b) in-person/mixed athletic assessment course- Skills exam Friday
c) online- adv genetics- quizzes on T/R, homework due Friday, Lab report due Friday

2) TA for a prof that has no experience w online coursework (logged 18 hours for this)
a) planned for online only Lab safety session and lab tech for non-STEM students
b) answered many emails/calls from students
c) some other stuff

how it panned out:

Sleep: 3-4 hrs/night on M-W, 0 hrs R-F, 2 hr Sa (I usually sleep 9-10 hrs and often take a nap)
Productivity: Increased from baseline on M-W. Steady decrease on R/ F. Perceived productivity increased F + S, actual productivity decreased.
Social: I made several faux-pas because of decreased awareness and experienced progressive loss of touch w reality. I talked to many friends on socials, which is unusual for me for when school is in session.
Physical: Baseline M-W, progressively worsening dehydration, increasingly worse R-Sa: hypotension + tachycardia. Decreased thirst+ hunger.

Tx on R-Su:

Brain fog and hypotension/tachycardia realized by fiance on F 2 am- dosed with salt until she said I could stop, catnip+chamomile tea w/ honey. Monitored until 4 am with additional salt doses and water w encouragement PRN. F 3 pm-severe brain fog, white-out: dosed with salt until she said I could stop, carbs, fat, protein and water. Put in bed w low stimulation and monitored. Sa 3-4 am- series of anosognosic panic attacks, called father (ex ER MD) in fear I was having a manic psychotic episode and needed to self-admit. Fiance not home. Triaged by father- he told me I was having a panic attack. That helped me calm down. Dosed w salt water, 100 mg hydroxyzine pamoate and 30 mg SL melatonin. Slept 2 hours. Sa 11 pm- dosed w salt water, PB w/ added sugar, catnip+chamomile+lavender tea, 25 mg Diphenhydramine and 10 mg SL melatonin. Decreased agitation. Su 12:15 a- dosed w more tea, 1000 mg Valerian root. If I cannot knock myself out I will take 50 mg diphenhydramine and 10 mg SL melatonin. If that does not help I will take 10 mg propranolol.

Reflection/Advice:

If I could go back I would have taken 150 mg on Su, 300 mg on M and 150 mg on T.

I recommend a benzo on hand.

I recommend setting timers for food and water.
 
This is my experience with a ER Wellbutrin (e-HL 20 +/- 5 h) high. Because of the pandemic I was unable to get a better upper so I used what I had.

5'7 115 lb 21 yo F

hx: (unipolar) major depressive dx, panic dx, hereditary spherocytosis

rx: fluoxetine (prozac, SSRI) 40mg o.d. AM cc

dosage: 300 mg on sunday 8/23 AM, 300 mg on monday 8/24 AM, 300 mg on tuesday 8/25 AM, 150 mg on wednesday 8/26 AM

why: 1) exam week of 7 week (typically 16 week) condensed (COVID-19) semester with 15 credits of pre-health courses
a) in-person/mixed A&P II- Lecture exam Monday, Lab exam Thursday, Homework worksheet due Friday
b) in-person/mixed athletic assessment course- Skills exam Friday
c) online- adv genetics- quizzes on T/R, homework due Friday, Lab report due Friday

2) TA for a prof that has no experience w online coursework (logged 18 hours for this)
a) planned for online only Lab safety session and lab tech for non-STEM students
b) answered many emails/calls from students
c) some other stuff

how it panned out:

Sleep: 3-4 hrs/night on M-W, 0 hrs R-F, 2 hr Sa (I usually sleep 9-10 hrs and often take a nap)
Productivity: Increased from baseline on M-W. Steady decrease on R/ F. Perceived productivity increased F + S, actual productivity decreased.
Social: I made several faux-pas because of decreased awareness and experienced progressive loss of touch w reality. I talked to many friends on socials, which is unusual for me for when school is in session.
Physical: Baseline M-W, progressively worsening dehydration, increasingly worse R-Sa: hypotension + tachycardia. Decreased thirst+ hunger.

Tx on R-Su:

Brain fog and hypotension/tachycardia realized by fiance on F 2 am- dosed with salt until she said I could stop, catnip+chamomile tea w/ honey. Monitored until 4 am with additional salt doses and water w encouragement PRN. F 3 pm-severe brain fog, white-out: dosed with salt until she said I could stop, carbs, fat, protein and water. Put in bed w low stimulation and monitored. Sa 3-4 am- series of anosognosic panic attacks, called father (ex ER MD) in fear I was having a manic psychotic episode and needed to self-admit. Fiance not home. Triaged by father- he told me I was having a panic attack. That helped me calm down. Dosed w salt water, 100 mg hydroxyzine pamoate and 30 mg SL melatonin. Slept 2 hours. Sa 11 pm- dosed w salt water, PB w/ added sugar, catnip+chamomile+lavender tea, 25 mg Diphenhydramine and 10 mg SL melatonin. Decreased agitation. Su 12:15 a- dosed w more tea, 1000 mg Valerian root. If I cannot knock myself out I will take 50 mg diphenhydramine and 10 mg SL melatonin. If that does not help I will take 10 mg propranolol.

Reflection/Advice:

If I could go back I would have taken 150 mg on Su, 300 mg on M and 150 mg on T.

I recommend a benzo on hand.

I recommend setting timers for food and water.


Sunday morning update:

Got much sleep. Sympathetic response not longer activated. Decreased HR and white spots in my vision are gone. Euphoria is gone. Racing thoughts gone. No noticable hangover. Hunger and thirst cues have not yet returned.
 
Maybe a pure bupropion hcl IV injection would be half worth it but I can’t imagine the chemical is safe in terms of physical/vein or seizure health even pure. Just less bad.
 
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