The 4,4 is better termed 4,p-dimethylaminorex since one of the 2 methyls is in the para position of the benzene ring. The p-Me increases serotonin releasing activity which offsets stimulant activity BUT more importantly, it provides the body with a convenient point for the body to metabolize the stuff. Plain 4MAR lasts 12 yours +. I didn't try 4,p-dimethylaminorex but my wife did and reported that it was much like p-Me aminorex having almost no stimulant activity.
The precursor for the 4,p-dimethyl derivative is more work and more cost BUT the final cyclization can be carried out using KOCN which is why I suspect it was chosen (the chemist behind it was behind benzo-fury... AKA US7045545B1).
(R)-6-methyl AMT is an excellent MDMA substitute. AET was sold as MDMA and possible 6-Methyl AET was sold BUT the 4-carbon analogues have a lot of MAOI activity which is why I stuck to a chiral 3-carbon derivative.
On a related note, I've also come across an opioid/DRI/NMDA which is without a shadow of a doubt the most euphoric compound I have ever come across. It has 2 enantiomers one of which is an opioid around the same potency as diamorphine while the other is a DRI around 25% the potency of cocaine and NMDA activity around thatof isophenidine. That one got dumped because it would be far, far too dependence forming. BUT my point is that such compounds are known. Sadly, the 'cooks' making fentanyl (and analogues) or U-47700 (or similar) are looking for the maximum profit from minimal effort. I am unaware of ANY research chemical opioid that was ONLY as potent as H. Of course, that meant that the DRI activity & NMDA activity could be reached before toxicity kicked in but it was too close for my liking.
I have posted before so I presume any interested chemists will have seen enough to know what I am on about - I just do not relish amateurs making the stuff (badly) and people being harmed. A white powder is NOT an acceptable dose unit.
In this case, a capping machine (or home made capping board) using number 4 capsules would be needed. Of course then people could open caps, cut and sell cut so the caps would have to go into blister-packs. I don't know about anyone else, but capping & packaging 20000 caps is a LONG and BORING job but of course, if you care about the end user, you have to do this.
We just added (invented) name and instructions for use in cyrillic script so those who chose to check would know exactly what it was, how much was in each cap, interactions and what to do in case of an emergency. Let me tell you, it took us a week of arguing to get SOMEONE to pack them. We even had boxes composed of 10 x 20 capsules and a cyrillic patient information leaflet.
That is when I realized that there is no such thing as easy money! The ONLY plus was that I found a 2-step route whereas the official routes took 5 steps including resolution & racemization so nothing was wasted.
The research chemical movement only uncovered a tiny amount of the stuff that is out these but while I do not mind being 'gray' legally, I won't break the law of the land.