RCs Tolibut (β-(4-methylphenyl)-GABA) Penibut Analouge

[Gordon's]

Tolibut (3-(p-tolyl)-4-aminobutyric acid) (β-(4-methylphenyl)-GABA)

So seems this is available, not much information on it yet. Its the 4 methyl analouge of phenibut and an analogue of baclofen where the 4-chloro substitution has been replaced with a 4-methyl substition.

A couple quotes from the wiki page

"Tolibut has been described as possessing analgesic, tranquilizing, and neuroprotective properties"

"It is not fully clear as to whether the drug was ever approved or used medically in Russia, though it may have been."

So anyone have anything more on this? Dosage? How does it compare to phenibut?

 

[weekend addiction]

Intrigued.

 

[Gordon's]

Heres some information from a paper I have no idea what any of it means but maybe someone more knowledgeable will get something out of it

 

[adder]

This table says nothing about effects at GABA-A or GABA-B receptors, it just says that phenibut and tolibut are weak, basically inactive, at inhibiting GABA uptake by synaptosomes. I imagine compounds decreasing GABA uptake in this study produce some inhibitory effects by increasing GABA concentration that is free to act at GABA receptors.

 

[mike.vick]

This table says nothing about effects at GABA-A or GABA-B receptors, it just says that phenibut and tolibut are weak, basically inactive, at inhibiting GABA uptake by synaptosomes. I imagine compounds decreasing GABA uptake in this study produce some inhibitory effects by increasing GABA concentration that is free to act at GABA receptors.

They've already said that phenibut's mech. of action is gabapentenoid - it is a voltage-gated-calcium-channel-blocker at the a2 subunit

Not via gaba-a or gaba-b receptors

Edit: spelling

 

[kleinerkiffer]

They've already said that phenibut's mech. of action is gabapentenoid - it is a coltage-gated-calcium-channel-blocker at the a2 subunit

Not via gaba-a or gaba-b receptors

Where did you get that from?
Phenibut

acts as a GABA-mimetic, primarily at GABAB
and, to some extent, at GABAA receptors. It also stimulates dopamine receptors and antagonizes
â-phenethylamine (PEA), a putative endogenous anxiogenic

From the new phenibut thread http://www.bluelight.org/vb/threads/794810-Phenibut-Discussion-Thread
And as far as I know that's correct

Edit, you seem to be right, I wasn't aware of the new studies, so I'll have to read up on it

 

[XANAX XR]

They've already said that phenibut's mech. of action is gabapentenoid - it is a coltage-gated-calcium-channel-blocker at the a2 subunit

Not via gaba-a or gaba-b receptors

Makes sense as I don't feel gabapentinoids and I don't feel phenibut.

 

[electric moon]

What I don't understand is that I was give gabapentin during phenibut withdrawl and it didn't help the wd symptoms.

 

[adder]

They've already said that phenibut's mech. of action is gabapentenoid - it is a coltage-gated-calcium-channel-blocker at the a2 subunit
Not via gaba-a or gaba-b receptors

Let me reformulate - the only mechanism of action studied was GABA uptake inhibition and phenibut as well as tolibut proved to be weak GABA uptake inhibitors, that information however means nothing with respect to their potential sedative properties that may be mediated via different pathways.

 

[Keif' Richards]

Definitely interested. Has anyone tried it? I'd like to know if it's more similar to Baclofen or to Gabapentin.

 

[ChodeMastaFlex]

I'll give it a shot. I'll start with 50mg and leave an update if I survive.

I'm excited to see how this turns out. Keep us updated.

 

[ChodeMastaFlex]

You are doing Gods work.

 

[d1nach]

I though generally chlorine was stronger then methyl bonds general for example chloroform makes u faint ethanol smelling it does nothing.

*not that its angoodnidea im just trying to show a example where a chlorine can drastically change a chemicals effects on humans

 

[Morninggloryseed]

Interesting post. Glad you can share this story.