I have decided to begin my trials of this one today. I just ingested 1mg. I will post my notes about getting it into solution below. I don't really expect any effects at 1mg, but who knows?
5-Cl-AMT Trials - Workup to Activity
by Xorkoth
1-18-2020 - First Trial
The substance in the bag had the appearance of a uniform, fine powder, ever so slightly tan, with a faint smell, but nothing like AMT itself, However, upon weighing it out, it is mostly made up of rather crystally chunks. Not like beautiful, grown crystals, but like hard, chunky pieces that can be crushed. I needed to make a solution, as my first trial is going to be at only 1mg. I weighed out 22mg of the substance, and at that point I realize all I have that isn't tap water is propylene glycol. So I measured out 22mg of water, got a clean, dry amber vial that holds just over 20mL, and it ended up just filling it, with exactly enough room left to provide the ability to shake it. Rather than break the chunks up, I left them, so as to be able to easily see whether the substance has dissolved.
Upon putting the 5-Cl-AMT in and shaking, the chunks are barely getting smaller, so I prepared a hot water bath and allowed the solution to heat up. Once it reached I would guess about 50 degrees C, I checked it, and the biggest chunk was mostly dissolved.
My set going into this is that I am extremely tired from too little sleep for a couple of days. I jumped off of opiates to get past my most recent relapse, and yesterday at like 5am I took some loperamide. Either the loperamide is still providing relief, or I am just pretty much past withdrawal. I feel pretty good, other than being tired. My setting is at home, about to start a day of work, alone except for my cat. In other words, my usual setting for trialling something where I do not expect strong effects. In reality I don't expect any effects, but I need to work this up very slowly.
A study suggests that 5-Cl-AMT has a bit more than twice the MAO-A inhibition as AMT itself, with an IC50 value of 0.25 at MAO-A (and much weaker inhibition at MAO-B, with a value of 80), where AMT itself has an IC50 of 0.38 at MAO-A. In theory, this should mean it is twice as strong an MAO inhibitor. It is also a pure dopamine-serotonin releaser, and has more substantial agonist activity at 5-HT2a (the linked study does not explore 5-HT2a agonism, but I have been told it is the case). This suggests that, if it is more potent than AMT, which it is reasonable to assume it might be, since 5-MeO-AMT is extremely more potent than AMT, it has the potential to be an amazing recreational drug.
Upon checking the PG solution, I am not 100% confident it is dissolved and not just suspended, as I seem to be seeing a bunch of fine particles. So I am going to let that solution sit around for a day or so and see if anything has settled to the bottom. In the meantime, I prepared a water solution of 5mg/mL, 4mL of water in a dram vial, with 20mg of 5-Cl-AMT, the lowest amount I trust my scale to be reasonable accurate with. After shaking for 30 seconds, the solution looks perfectly clear.
I have had caffeine so far today, and that's it. The caffeine succeeded in making me feel awake, rather than having trouble keeping my eyes open.
10:00am (T+0:00) - I ingested 0.2mL of the water solution, or 1mg of 5-Cl-AMT. What a strange taste. I was keeping it in a baggie, in a box, along with a baggie of MXiPR, which is such a stinky chemical, with a strange melted/burned plastic smell; I smell that same smell when I smell the baggie of 5-Cl-AMT, and I taste it a little when I ingested it. There was an additional taste that is leaving an almost sweet aftertaste. I'm not sure how much the taste is due to picking up some MXiPR smell. I am going to spend a little time now getting my newest chems into vials, as my whole closet smells a little like MXiPr.
I'll update later if anything develops.