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☛ Official ☚ The Small & Handy 5-Chloro-AMT thread

Xorkoth

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So I have received some of this. From what I've read, it appears to be serotonin and dopamine releaser, but not epinephrine at all, unlike AMT itself. In addition it is about twice the affinity as AMT for 5-HT2a which points to it being a stronger psychedelic, while still possessing some nice releaser properties. The worry is that it is almost totally unknown and untested, and if it were to be a potent MAOI, it could be dangerous. I am considering that it might be the potency of 5-MeO-AMT, ad also might be much more psychedelic than AMT, like 5-MeO-AMT is, but it should also be rollier and have less bodyload (theoretically less than AMT, as well, though who can say). Apparently it is one of only a few known purely serotonin/dopamine releasers, and has been studied for cocaine dependence in animals.

I plan to trial it soon at 500ug, and then move up from the in successive trials. :)
 

Xorkoth

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I'm not sure I understand your question? I have not tested this compound yet. What is a "superagonist"?
 

Xorkoth

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Ah I see. Well I am not sure if I have tried other "superagonists", or if 5-Cl-AMT even is one. It has double the affinity for 5-HT2a compared to regular AMT, but regular AMT is mostly a releaser and not a strong agonist.
 

Hexagon Sun

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Im a sucker for AMT and 5-subs-Ts, so this one seems like a potential winner in my book. I always wanted to try 5-meo-amt despite the bad press... but finally didn´t.


Let´s see about potency and duration. And qualia, for sure. I would speculate you are going to have some microdose effects for 500ugs... Lets see
 

Xorkoth

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Yeah if this is even in the ballpark of 5-MeO-AMT potency, 500ug will probably have some little effect.

I have tried 5-MeO-AMT a handful of times when I was much younger, I found the bodyload heavy, but I had some really nice experiences, too. It's much stronger as a psychedelic than AMT is, but a lot less rolly, too. I'm really hoping 5-Cl-AMT is somewhere in between AMT and 5-MeO-AMT.
 

Anonymous Dissident

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Im a sucker for AMT and 5-subs-Ts, so this one seems like a potential winner in my book. I always wanted to try 5-meo-amt despite the bad press... but finally didn´t.


Let´s see about potency and duration. And qualia, for sure. I would speculate you are going to have some microdose effects for 500ugs... Lets see
Trust me, you didn't miss out on anything by skipping 5-meo-amt. It's the roughest compound I've tried from a physical discomfort perspective and lasts forever. It's one of the only substances I've tried with no redeeming qualities whatsoever. Its the tryptamine answer to 2c-t-4, just lacking the dissociative properties.
 

Xorkoth

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I actually thought it was pretty good, but the bodyload price made it not worth it for me, considering that plenty of other psychedelics are equally or more powerful as psychedelics. I will say that twice I encountered a pretty awesome euphoric trip that I felt was worth it. Regular AMT has bodyload too, but I find it to be always worth it. I'm hoping 5-Cl-AMT is more like AMT than 5-MeO-AMT.

The suspected duration makes it harder to find time to trial this and work up the dosage so it may be some time before I can provide information on this. But I want to do my first trial or two quite soon, as I expect the early trials to be threshold at best.
 

Anonymous Dissident

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I actually thought it was pretty good, but the bodyload price made it not worth it for me, considering that plenty of other psychedelics are equally or more powerful as psychedelics. I will say that twice I encountered a pretty awesome euphoric trip that I felt was worth it. Regular AMT has bodyload too, but I find it to be always worth it. I'm hoping 5-Cl-AMT is more like AMT than 5-MeO-AMT.

The suspected duration makes it harder to find time to trial this and work up the dosage so it may be some time before I can provide information on this. But I want to do my first trial or two quite soon, as I expect the early trials to be threshold at best.
Are you planning to take reasonable precautions to prepare for any significant MAOI activity? I've wondered if MAOI activity is behind the awful body load of 5-meo-amt, but on the other hand, AMT itself never caused me any physical issues anywhere close to those caused by its 5-meo counterpart.

Off Topic: Has any study been done on the MAOI activity of AMT vs. 5-meo-amt? I haven't seen one, but I'm very curious how they compare in that department. If 5-meo-amt has significantly stronger effects on MAO, a lot of the negative physical effects would make sense. Clinically significant MAOI activity, exceeding that of AMT, could also help explain why some people have very minor side effects and some (like me) experience such horrific ones. Simple things like variation in diet could make a major impact on the experience.
 

Hexagon Sun

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AMT is a weak MAOI per se. As 5-meo-amt is more potent and therefore less dosage is needed, probably is even a softer MAOI if any. This is speculative but I would say somewhat solid

I think the bodyload comes more for the activation of adrenergic receptors or any others than 5-ht2 type causing it
 

Xorkoth

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Are you planning to take reasonable precautions to prepare for any significant MAOI activity? I've wondered if MAOI activity is behind the awful body load of 5-meo-amt, but on the other hand, AMT itself never caused me any physical issues anywhere close to those caused by its 5-meo counterpart.

Yes, my plan is to abstain from foods high in tyramine when I dose it, and start with 500ug. I will work up by doubling the dose until I find a threshold of definite effects, but ideally, very light. At that point I will take the same dose without worrying about diet and see if there is a difference. At some point I will probably stop doubling if the dose gets to 8mg and I still don't reach the threshold, and raise by smaller amounts.

I have never worried about diet for AMT or 5-MeO-AMT. The MAOI dangers of AMT are overstated, IMO, though of course an abundance of caution is preferred over a lack of caution. Of course, I am making no such assumptions about 5-Cl-AMT.

any idea why 4-ho-amt isn't a thing?

Nope, I wonder if it has ever been tried? I think that the roughness of 5-MeO-AMT might have stalled out experimentation with other analogues of AMT.
 

gno

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Nope, I wonder if it has ever been tried? I think that the roughness of 5-MeO-AMT might have stalled out experimentation with other analogues of AMT.

Alexander Shulgin mentions trials in Tihkal:
The 4-hydroxy analogue of a-MT has been looked at in human subjects. It is reported to be markedly visual in its effects, with some subjects reporting dizziness and a depressed feeling. There were, however, several toxic signs at doses of 15 to 20 milligrams orally, including abdominal pain, tachycardia, increased blood pressure and, with several people, headache and diarrhea
 

Xorkoth

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I was looking for some information on 5-Cl-AMT... I found this study, which I believe is showing that 5-Cl-AMT produces slightly less MAO inhibition than AMT itself (and far less than 5-MeO-AMT), and is one of the lowest of the 13 mentioned AMT analogues. But I'm not 100% sure on that.


Or actually perhaps it is slightly more than AMT, not less... I see that harmaline has a very low value, and is straight up an MAOI. In either case, 5-Cl-AMT seems to have a similar value for MAO-A inhibition as AMT. If it is substantially more potent (we don't know if it is, yet), then that would mean it wouldn't be much of a concern, right? Since one can take AMT at 75mg or more (of the freebase) without serious concerns, provided you don't mix it with other releasers. I have done so hundreds of times in my life. Of course I am still going to be really careful. I'm just trying to gather whatever intel I can before beginning trials. I'd appreciate if anyone else checked out the link above to help me understand what it tells us.
 
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Didgital

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any idea why 4-ho-amt isn't a thing?

It is a thing, it's just not on the scene really.

The 4-hydroxy analogue of αMT has been looked at in human subjects. It is reported to be markedly visual in its effects, with some subjects reporting dizziness and a depressed feeling. There were, however, several toxic signs at doses of 15 to 20 milligrams orally, including abdominal pain, tachycardia, increased blood pressure and, with several people, headache and diarrhea.

— Alexander Shulgin, (TiHKAL)
 
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