How much Loperamide would you use to stop a 60-80 mgs of Morphine (oral because the substance being used is actually opium) after a 2 week consumption? How would you go about tapering the Loperamide? Would it be possible to stop without much drama because I'm around family? Thanks.
Instead of 8-10 lops (which is 16-20mg loperamide which is very little) that nzity suggested I'd recommend 32mg, but you can try 10 first, problem is that it takes 5 hours to get the full effects of loperamide, so if 20mg loperamide don't help and you take more you have to wait another 5 hours, take them as soon as you wake up and to empty stomach, 30mg DXM might help with WD's and will potent loperamide, also grapefruit makes it stronger, if it's available take tablet form of loperamide not the capsule ones.
I would start straight from 32 mg and see if it helps, if not take another 32mg at the same day. Max. recommended loperamide dose used daily for various diseases is 16mg as it can cause even life threatening problems with heart at very high doses over 100mg, but I've never had them and I've used loperamide over 100 times max. dose 220mg with amphetamine even. But 64mg is fairly safe. If it's enough I would start to dropping it by 10mg per day, or even 20mg, just look how you feel, sometimes for me it's enough to take it once in 2 days, if I quit codeine I need to take it every day, with oxycodone it's enough to take every other day for some reason, also I get much more faster wd's from codeine than from oxycodone.. I've quit my many long opioid binges with starting 64mg next day 32mg, and after that 32mg and then 20mg and 10mg. Some people taper with it 6 months, dropping the dose very very slowly, 2mg a day.
When I used huge doses of opium/poppy pods/seeds whatever was available for 2 years without single break (so I had some opioid in my bloodstream 24h every day) only 200mg loperamide stopped the WD's on days when I run out of poppies, 200mg oxycodone didn't give any feeling only took the wd's off even when taken with poppies I didn't feel anything, but 200mg of loperamide with poppies/opium made me nod hard if I did once a month. In the end only fentanyl gave warm feeling and 200mg of
U-47700 got me nodding very hard (and that is very strong dose considering that 50mg is very high dose according to psywiki) after that 2 year poppy binge, and I didn't get any nodding from the poppies for a year no matter how much I took it made me actually very stimulated like on speed. I made tea from it and basically drunk it like alcoholics drink alcohol, so every 1 hour. Smoked few times real opium but that was very hard to get, maybe with that I would nod even after 2 year use.
When I quit 2 year use of poppy products I took loperamide 120mg only 1 day a week and then gabapentin, pregabalin, phenibut, GHB, amphetamines or benzos rest of the week, after 1 month I was fairly ok, last dose was 32mg and after that got mild WD's but still had insomnia and sweating for 1 week, so I took quetiapine or mirtazapine for sleeping, quetiapine also reduces anxiety IMO. 2 weeks opium use shouldn't give you that hard WD's so low doses loperamide is ok.
I'd say 8-10 loperamides for the first 2 days once a day is enough then if you have some gabapentin on hand u can take that aswell.60-80mg morphine orally is not that much imo so ur wds won't be that harsh. Good Luck on it, i'm on day 3 myself i only have diahrrea and some mild chills, i just took my gaba so it hasn't kicked in yet.When it does i might feel better. Stay safe NZN
He used opium which means there are 7 different opioid alkoloids and the morphine half-life in poppy products is as long as methadone. It's much harder to stop opium than oral pure morphine. I've done both. Years of daily use of poppy products and then stopping it cold turkey is one of the most terrible experience I've had, only my daily 2g pregabalin use for 4 months can be compared to it. Interesting thing is that when I quit 2 months of daily 1g tramadol (with small doses of diazepam to prevent seizures) I used buprenorphine 0,5-1mg for 3 days and didn't get any WD's.
Also now I get good buzz from jsut 60mg of codeine, which didn't give any feeling to me even when I was totally opioid naive, 20mg oxycodoen is enough for me, my opioid toelrance have gone totally zero even far beyond because they work much better than the first times 15 years back.