There's something like that in the 'scheme 2' of this article, where ethylene glycol + ammonia turns into aziridine at high temperature:
wonder what the mechanism is for this
When methyl benzoate is volatilized and then highly diluted with a gaseous non-odor masking diluent, the aroma of cocaine is provided. Similarly, when a mixture of methyl benzoate, methyl cinnamate and the dimethyl ester of truxillic acid is volatilized and then highly diluted with a gaseous non-odor masking diluent, the aroma of various grades of "street cocaine" is provided.
A unique feature of the present invention is that the aroma of cocaine is not merely imitated, but rather, the actual aroma of cocaine is provided without the use of any cocaine or cocaine related materials. Since the actual aroma of cocaine is provided by the present invention, it is possible to use the present invention to establish a chemical model for the aroma of cocaine. This chemical model may then be used in various qualitative and quantitative analytical techniques.
Looks like this chemical is about as toxic as fluorine gas according to some estimates.Potential for release of pulmonary toxic ketene from vaping pyrolysis of vitamin E acetate
Dan Wu and View ORCID ProfileDonal F. O’Shea
PNAS March 24, 2020 117 (12) 6349-6355; first published March 10, 2020
A combined analytical, theoretical, and experimental study has shown that the vaping of vitamin E acetate has the potential to produce exceptionally toxic ketene gas, which may be a contributing factor to the upsurge in pulmonary injuries associated with using e-cigarette/vaping products. Additionally, the pyrolysis of vitamin E acetate also produces carcinogen alkenes and benzene for which the negative long-term medical effects are well recognized. As temperatures reached in vaping devices can be equivalent to a laboratory pyrolysis apparatus, the potential for unexpected chemistries to take place on individual components within a vape mixture is high. Educational programs to inform of the danger are now required, as public perception has grown that vaping is not harmful.
It seems that the cathinone analogues of methylphenidate are significantly less potent DRIs, but the ring-subsitution SAR tracks well:Synthetic cathinones are, primarily, stimulant drugs of abuse that act at monoamine transporters (e.g., the dopamine transporter or DAT) as releasing agents or as reuptake inhibitors. In the past few years, the emergence of >150 new synthetic cathinones has attracted considerable attention from medical and law enforcement communities. threo-Methylphenidate (tMP), used clinically for the treatment of ADHD and narcolepsy, is also a DAT reuptake inhibitor. tMP is somewhat structurally similar to abused cathinone stimulants, and the structure–activity relationships (SAR) of tMP have been well-defined. Hence, available tMP literature might assist in understanding the SAR of synthetic cathinones, about which less is known. In the present study, we synthesized and examined eight 2-benzoylpiperidine analogues (4, 6–12) to determine if tMP SAR might be applicable to cathinone SAR. The benzoylpiperidine analogues were evaluated in a competition assay using live-cell imaging against APP+ in HEK293 cells stably expressing hDAT and in cells coexpressing DAT and voltage-gated Ca2+ channels. All compounds were found to be DAT reuptake inhibitors, and a significant correlation was obtained between the potency of the benzoylpiperidines and tMP binding data (r = 0.91), suggesting that the SAR of tMP analogues might be directly applicable to certain synthetic cathinones as DAT reuptake inhibitors.