experiences tend to change people. experiences on/with lsd tend to be very powerful, so there is potentially a powerful change. IME, yes, very much so. Though after some time without psychedelics, old patterns do reinforce themselves unless I work on them. What has mainly changed for me in the long run is my awareness of self and surroundings. But even awareness kina goes back to "normal" after some time. I like to take LSD again after such time, as a reminder of my potential..... true change comes from within, not from any drug. Drugs are catalysts. Granted, LSD is a poweful catalyst.
A more mundane way of answering the question:
When i first took LSD it left me in a perpetual state of doubt and uncertainty and all this brings with it.
After having taken LSD many times over many years I can day it has made me a more self-confident (even if less cocksure and less arrogant) and more compassionate person. Kinda self-critical and self-confident at the same time, due to increasted self-awareness. And more trusting in the sense that I like to think that what happens may be shit but it is what is supposed to happen, si it's up to me to accept it. It was LSD that first made me aware, all from within myself, of basic Buddhist/Taoist concepts (well before I had ever read anything at all about these ways of assessing life).
I am very grateful for that, and I intend to eat more LSD from time to time, not least for these reasons.