O-PCE is likely in my top 5 drugs of all-time despite having only used relatively low doses (~10-14mg + a similar redose with a decent disso tolerance). I have a close friend who feels the same.
Interesting anecdote, when I met very well-known psychonaut/chemist last year (to remain unnamed for privacy), it was the only thing I had to offer, and while he didn't partake due to having an early flight he also expressed it being his current favorite drug to my surprise.
After finding a small stash of MXE recently, I think I actually prefer O-PCE, at least in lower doses. It feels more functional and clear-headed. But after a year of regular K issue however, I'm unable to compare things at baseline.
Also after reading some of the speculation on O-PCE being potentially risky with regular use do to hypothetical antibacterial/antimicrobial properties, I'm a bit more risk-averse with it. If anyone has a definitive rebuttal to these claims, I'd love to know (probably discussed to death here, but I've been out of the loop). The study published in HK showing a large cluster of adverse effects is another reason I want to be cautious and not assume it has same relative safety as MXE.
At that this point it seems to be a gone for now, so I've been dabbling with 3-MeO-PCE. My initial impression is that it lacks much of the magic of O-PCE, and has less of the perfect hypo-mania (in contrast to the more forceful and less forgiving raw power of 3-MeO-PCP), it's still quite well-rounded, and may be the best thing available (for me at least at this point).
Based on the receptor affinity studies, 3-MeO-PCE/O-PCE seem to share MXE's far more complex pharmacology compared ketamine which make them 'deeper' in many respects, but with more room for unexpected interactions and risks when the tolerance to the NMDA effects builds rapidly, while the secondary effects can be cumulative with re-dosing...
(Btw Xorkoth, I wrote you a long PM, but it got lost before I sent it I'll try again soon)
Found my sweet spot at slightly below the doses Of take when using the substances on their own. IV 17mg with 3mg 2C-E right after 8mg oral/rectal.
Comes out to roughly 35mg+12mg orally, the latter of which is a pretty standard dose for people who aren't used to tripping. So for 2C-B I'd use 4.5mg IV or 18mg orally.
Anymore psychedelic and I'll vomit, anymore dissociative and I'll get amnesia. Any less psychedelic and the trip won't be colorful enough for my taste, less dissociative will have me 'remain in this world '. It's very tricky to get the doses right for the type of experience I'm usually seeking. It took a lot of trial and error to figure them out, which took many months filled with disappointments, since I can't use them as often due to having to have my wife be ok with the frequency. She hates seeing me on dissociatives, understandably so.
Back when I first met her she had never come in contact with psychedelic drugs. The third or fourth time I saw her I arrived bleeding from my broken elbow after crashing my bicycle into a traffic light lol, without even realizing the damage.
It's a miracle she didn't reject me after that happened, since I always considered her slightly out of my league. It sure took some fighting to have her marry me and it was a rock road to get to where we are now, but I digress.