I'm wondering what a good dose would be to start with, besides allergy testing. It seems people are shooting for the 350-500ug range. How hard are you tripping on, say, 350ug compared to 500ug?
Also, I have been thinking that maybe sublingual absorption has similar issues to salvinorin, meaning that bioavailability could be greatly increased by using mouthwashes etc. prior to dosing.
Intranasally, yeah, 350-500ug seems like a good start for most people here.
The most I've taken so far was 330ug with mxe. It was just touching on open eye visuals at that level, I remember the ground bubbling at one point and the sky flickering between inverted and normal colors, and the stimulation wasn't too pushy, although I would liked to have slept sooner.
I'm not sure how much the mxe potentiated but it definately helped create a calm sort of void for the effects to manifest.
the sublingual effects do seem to vary a lot.