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The Big and Dandy DOI Thread

blowjay

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How did it go?
It didn't.

Peripheral stimulation that made it a bit hard to sleep was the only thing noticed. It amazes me that something as strong as DOI won't be felt due to anti-psychotics. I expected to feel at least SOMETHING but no, didn't happen.
 

Cosmic Charlie

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Hmmm...wonder if Salvia Divinorum would work.
The Kappa Opioid receptor it hits causes the psychedelic effects. That's a hell of a trip though, not for the faint of heart. Considering you are struggling with mental illness you really need to be careful taking drugs.

This is a harm reduction site, your mental health can get worse. Just try and be careful on this quest, i know you miss tripping and its difficult to give up. But considering my sister has severe schizophrenia, I've seen a person become more and more detached due to the use of psychedelics and dissociatives. Caught up in complex delusions of hell and damnation. She used to be skitzo effective, the drugs made it worse.

She struggles every day
 
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Buzz Lightbeer

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I tried this last week. 4.5mg, I took three 1.5mg blotters sublingually, the guy I got it from said I should take 'em this way. They were nasty, very bitter and burnt my mouth a little.
I figured I had about half an hour to an hour for first effects so I wanted to shower and buy some fruit while waiting for it to come up. I felt the first effects after 5 minutes already, which was not according to plan, about 10 minutes later I started to notice the first visuals and another 10 minutes later my whole field of vision was moving, it was very intense. I tried to puke but not much came out, I was literally panicking at this point, never had this happen to me before but I was so far gone and not thinking clearly. It took another half an hour or so to finally leave my room to go to my friend after I had called another friend explaining my situation, it was quite the walk, the visuals were insane and I could barely see in front of me. It was raining hard and I felt ego death approaching, I fought it (or at least I think that was what was happening, I never experienced ego death, even on high doses of psychedelics, still on the to experience list :) ), it took ages for me to find my friends place, I could hardly see anything and I was just walking circles by the end, eventually he came to get me, bless him. I was calmed down at that point but still extremely relieved to be away from all people and noise.
Once at that friend I was very stimulated, loud and tripping insanely hard but still quite clearheaded throughout. He had two friends over which was hard because I couldn't shut up, I was reaching for some people that would understand both me and DOI but no other friends were available, wrote some major nonsense both on here and on messenger in an attempt to get a hold on for what was about to come, pretty funny looking back. I stayed there for a couple hours, talking and laughing, but after 4 or 4 and a half hours after dosing all of the visuals subsided and I didn't seem to be tripping as hard anymore, weird, because I thought my peak was still to come lol.

Eventually I left and i all that was left was a classic very long DOx tail, I slept at +20:00 or so for a couple hours but I could still feel remnants of the drug until I went to sleep later that night. I can see why people don't like DOI for exactly this reason, but I really like an psychedelic amphetamine tail, time flies by, I just feel so great and I have great fun doing whatever I feel like. Also what it lacks in real headspace it makes up for in major fucked-upness, it's baffles me I was able to still function quite well (searching for my stuff, calling and texting friends..).

Certainly an experience to be remembered, it's a shame the main part of the trip was over so fast, I wonder if taking the blotters sublingually had anything to do with it or if it was just my body and brain.
Cool drug and I look forward to trying again, might up the dosage and just swallow 'em, I would not recommend starting at 4.5mg the first time though, I got a little cocky but hey you live and learn. I can see why people took this back in the day but I've got a feeling DOB might be the real king of DOx, next on the list =D
 

Xorkoth

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I didn't care for DOI when I took it, it seemed rather generic in character but also very stimulating. It didn't give me any euphoria or very interesting content. I am going to give it a proper try sometime but it's low on my list - I do have some but there are a good number of things I'm going to do first. I'm planning to do either DOPr or DOB soon. Probably DOPr (I've taken a lower dose and felt that it didn't fully develop). For me, DOC is still the best (out of DOC, DOET, DOF, DOI, DOiP, DOM and DOPr), it just has it all, everything I look for in a psychedelic and virtually nothing that I don't like (vasoconstriction is about the only thing I can think of).
 

Buzz Lightbeer

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DOI was way more comfortable than DOC for me though, stimulating but not overly so. I agree that it doesn't come close at all to DOC but man is it an experience.

Just experiencing something completely new is all the motivation I really need.
 

Pfafffed

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DOI is one that I really want and am sad that I never picked up back in the day. It's not because I want to use it as a psychedelic–that sounds miserable–but because I want to nanodose it for systemic inflammatory issues. It sounds really promising for tamping down all kinds of systemic inflammation at a subpsychoactive level
 

Cosmic Charlie

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I've never heard about DOI helping inflammation before. Learn something new here everyday in PD, thanks for sharing guys :D

Do any of the other DOx do this and have they figured out why it's happening with DOI?
 

Img_9999

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Mind-blowingly amanzing, izo, thanks fro sharing !! Havent read past the abstract, but if it's 5HT2A-R activation alone that mediates the anti-inflammatory effect, then most psychedelics should share this property.

Of course, DOx are special in that they are full agonists at that receptor (IIRC?), so whether you need full agonism to bring out this effect is not clear to me.
 

Inzo

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I never found Doi to be anything special. Not that visual or profound at regular doses. Did 4.5mg-5mg once and although the wide array of effects were considerably weak, while watching porn on cinemax back in 2007, I was getting to the point of climax just from watching. Very deep, virtual reality like or maybe synastasia like senses were making the porn automatically make me feel influenced by it to the point of being overwhelmed. Kind of scary intense feeling. 4mg-5mg is overdose ime
 

Xorkoth

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Well yeah considering it's strong at like 2mg. 4-5mg is a very high dose.

However I agree, DOI doesn't seem to have anything special about it, subjective effects-wise, even though it's a strong drug. DOC is so much better than it leaves DOI in the dust.
 

Chris Timothy

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Mind-blowingly amanzing, izo, thanks fro sharing !! Havent read past the abstract, but if it's 5HT2A-R activation alone that mediates the anti-inflammatory effect, then most psychedelics should share this property.
It's even broader than that, non-serotonergic psychedelics do stuff like this as well. Cannabinoids (especially THC) have an influence on the immune system. And salvia can be used to lessen the effects of inflammation too.
 
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