I mis-posted. The term is "excitotoxicity", not hypertoxicity.
Insults to the brain cause it through a variety of means, direct and indirect. There are a few simple and relatively inexpensive ways to mitigate brain damage (ibuprophen, vitamins C and E, aerobic exercise to improve brain vasculature etc), as it only occurs through a few major an influencable mechanisms: metabolic, inflammational, and mechanical, all of which cause excitotoxic symptoms and eventually neuronal apoptosis (cellular suicide) or necrosis. For example, free radicals react with neuronal membranes and compromise their integrity, leading to swelling and eventual rupture. The contents of the ruptured neuron include high levels of calcium, glutamate, and NMDA, all excitatory neurotransmitters. The high concentrations of these chemicals within the synapse cause a sustained depolarization of the neuron, resulting in a kind of cellular seizure and exhaustion of metabolic reserves. This eventually causes membrane collapse, spilling of excitatory neurotransmitters etc., starting a chain reaction. A great deal of damage from strokes, for instance, comes after the initial hemorrhaging as a result of excitotoxic mechanisms. As you may have gathered, all the symptoms addressed by anti-inflammatories, anti-oxidants, and free-radical scavengers are interrelated. Whatever damage AMT may do directly, while it is in your system, is probably largely unavoidable. However, using these therapies you can hopefully lessen any ensuing damage caused by the discussed mechanisms. I think I’ve related the gist of it, however this is all from memory and there could be errors/omissions.
But YMMV, obviously, and with a new chem always start low - Erowid trip reports include a number of trainwrecks and trip disasters with high-dose AMT.
