The original thread by phrozen had reached its limit of 1000 posts. Thanks to phrozen for writing this. Its been a huge asset to OD. The original thread with all its posts can be found in the OD archive.
phrozen said:What: Suboxone = buprenorphine/naloxone. Bupe is a partial agonist(mu) and antagonist(kappa). Bupe has higher mu affinity that most opiates, including some antagonists(naloxone, naltrexone). Its higher affinity allows you to shoot suboxone tablets. It also may cause precipitated withdrawals if you are dependant on other opiates. Also, its higher affinity blocks the affects of other opiates when taken in conjunction with bupe.
Dose: Depends on tolerance. 1-2mgs is a typical recreational dose for someone with no tolerance. If you're using bupe to taper off of another opiate, you should dose once you're experiencing wd's(typically 36-48 hrs. for most opiates). Start with 2-4mgs and dose at 2mg increments every 30-45minutes until a dose holds you. Most people take their full dose once a day.
Withdrawal: Typical physical and psychological symptoms associated with opiate withdrawal. Insomnia, chills, diarrhea, depression, anxiety, lacrimation, sweating, increased heart rate, etc. They are not as strong as a full agonist's symptoms, but may last longer. Physical symptoms last 1-2 weeks on average and psychological symptoms may last months.
As most opiates, it's recommended to taper down to the lowest dose possible before stopping. <1mg is ideal. The best way to dose at that level is to crush up a tablet and divide the powder into lower doses.
- Bupe is CIII in the US.
- Metabolized by CYP3A4(see potentiation thread for potentiators).
- Half-life: 37 hours.
- Drug tests: Not detected by regular 5 panel tests.
- A interesting thread by 'medicine cabinet' about a new version of Suboxone that's currently being tested can be found here.
- Buprenorphine gets metabolized into norbuprenorphine and into conjugated buprenorphine and norbuprenorphine.
- Severe opiate withdrawal in a heroin user precipitated by a massive buprenorphine dose
- Bupe half-life charts- courtesy of Motts
- Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction. -courtesy of thugpassion
I couldn't find photos of Tamgesic, and Buprenex just comes in vials
Locate a doctor that prescribes Suboxone.
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