N&PD Moderators: Skorpio | thegreenhand
Wellbutrin is a NE releaser not a NRI with neglible da activity, 20& reuptake inhibition to be exact, which MAY be sufficient for some people, that said NRIS are usually sedating by activating one of the ne receptors which decreases NE, i forgot which kind it was, as an example reboxetine a pure nri is sedating initially.
That said from reports it seems that bupropion has unique prosexual effects which may be unrealted to its NE release but that is just speculation.
In the worst cases the addition of amphetamine or another strong dopaminergic would be needed, but that depends on your individual case.
Anti parkinson drugs, pramipexole in particular has been shown to have potent antidepressant effect, which is not suprising since da, rather then se is implicated in depression, ill provide references if asked.
Yeah that theory that a stimulant would counter the dysfunction, well, it doesn't apply to me at least.
Dopaminergic - again, my familiarity with pharmacology is quite lacking but, a dopamine agonist vs a dopamine antagonist.
Does antagonist suggest reuptake inhibition?? As oppose to secretion... as something like a stimulant would do.
Noradrenaline reuptake inhibition acts in a sedating manner??
Does that explain why something like Cymbalta is reported as more sedating than effexor - given the NorAdren to serotonin reuptake inhibition ratios??
Because from what I understand - effexor is considered a stimulating anti-depressant, carrying hardly, if ever, sedative properties, when examined subjectively.
Where as (correct me if I'm wrong), cymbalta carries frequent reports of drowsiness, fatigue, lethargy etc.
I'm 9 days in on 225 mg of effexor, and had an off day today.
I'm hoping to mitigate these off days, so I can get back to work.
A poster mentioned earlier in the thread, that reuptake inhibitors, as oppose to agonists, take time to reach equilibrium and carry the full anti-depressant effect.
How long would we be taking??
Max dose 375mg of effexor, so I have two more titrations before I consider switching.... moving either to cymbalta, or the tricyclics, probably elavil or something.
So - fill free to enlighten me.
Or, if someone can point me to a research link where I can read up on this material myself, that would be swell.
Yeah that theory that a stimulant would counter the dysfunction, well, it doesn't apply to me at least.
Does antagonist suggest reuptake inhibition?? As oppose to secretion... as something like a stimulant would do.
Max dose 375mg of effexor, so I have two more titrations before I consider switching.... moving either to cymbalta, or the tricyclics, probably elavil or something.
.
Like I said before, cabergoline is the " go to" dopamine agonist for ed issuers related to ssri treatment.
Cabergoline has issues (potential cardiotoxicity) -- discuss with your doc.
Honestly, if it is because of high prolactin -- NOTHING will work other than a dopamine agonist.
Anti parkinson drugs, pramipexole in particular has been shown to have potent antidepressant effect, which is not suprising since da, rather then se is implicated in depression, ill provide references if asked.