Memantine and Bromantane are in the same family of drugs (adamantane). It is thought that the affinity of memantine to the sigma receptor is at least partly responsible for some of it's pharmacokinetics, and it is also possible that bromantane shares some similarities with other drugs in this class. Although this is just speculation from a limited academic background. I've had a batch of memantine stashed away, but I've been apprehensive to give it a whirl since I've been studying hard for the past year. I may give it a whirl soon though at a low dose to feel it out. What was your experience with it like seiko?
The synergy of 9-methyl-β-carboline and bromantane seems to lie in the upregulation of transcription of the genes that express tyrosine hydroxylase. If I'm correct, that would be why 9-methyl-β-carboline didn't elicit a very profound effect as a standalone nootropic. But when combined with Bromantane, it was quite profound.*
*Edit; Any MAOI will cause a reduced rate of metabolism of monoamines, thus causing a build up of them in the CNS and peripheral systems. This is now a little more clear to me, and elucidates as to why caution must be exercised when administering MAOI's with any other drug. Start low and slow, you can always take more, but you can't UN_TAKE the shit once it's in circulation*
*I also have experience with Bromantane as a standalone compound and the same is true for it on it's own. Also, it should be noted that each does have a desirable (for me subjectively at least) effect, even though subjectively mild. If everything about their known / assumed pharmacokinetics and mechanisms of actions holds true, they both hold valuable potential for recovery and adaptation. The biggest possible negative attributes would be photosensitization from 9-methyl-β-carboline, and beta amyloid plaque formation from Bromantane. For this reason, I'll be keeping the courses of these drugs relatively short (14 days or so).
I would like to try to find an appropriate combination dose for the 2, as this would lower the amount of each drug I could administer and still see positive results. This would also presumably decrease the possibility of negative side effects, and presumably it will take some experimentation.
My proposed dose will be something like 10 - 15 mg 9-methyl-β-carboline, with about 50 to 100 mg bromantane. I may start with less though, to do a proper (ghetto) assay. 5 mg 9-methyl-β-carboline and 25 mg seems like a good place to start since I've already tried 15 mg (9-m-bc) with 50 mg (bromantane) of each compound simultaneously.
If I was to map out the quantity of each that I have, to make them last just as long as each other so they can be administered in tandem for more than one cycle, that would be ideal. However, I don't see that being a good reason to set a dose. The dose should be reflective of the best possible outcome subjectively.
The Selank, I plan on trying intranasal spray initially at a low to moderate concentration. I have 25 micron filters for making an injectable solution, and I will give nasal a try first, to see if it works. And whether it does or not, I will still experiment with sub Q, and IV to compare the differences. Logically, IV would be the best way to deliver the peptide to target organs before it breaks down in the body.
It should also be known, that just because a peptide breaks down quickly in the body, does not mean it's effect will be short lived. The downstream effects of the binding of said peptide will cause a cascade of physiological and genetic transcriptional changes / effects in the body.
All this information taken into account, I will be getting the compounds in question tested by mass spectrometry to verify their legitimacy prior to administration. I'll post all the results subjective and anecdotal as they unfold. Very excited for this round.
The goal is to increase desire to engage in productive behavior, reduce craving for adulterants, increase productivity, hopefully attain the same energetic boost as last time, and hopefully to reduce anxiety. This combination of goals is reflected quite readily by the proposed subjective effects of the specified nootropic drugs / peptide in question. I will also be paying attention to training. Since the last round, training has seemed subjectively much more difficult off the nootropics, however I am still dealing with the fallout after a decade of AAS use. March marks my 12th months post anabolics use, and I have an appointment with a private care doctor to see if I may benefit from HCG therapy, and if that alongside lifestyle changes does not bring my hormone profile to a more optimal range, we may consider testosterone optimization therapy.
