pizzystrizzy
Bluelighter
- Joined
- Apr 4, 2013
- Messages
- 91
So I'm not an opiate guy and have no immediate interest in this, but I came across this article in the process of doing some entirely unrelated research, and I thought it was interesting, particularly b/c I can't find any reference on bluelight of anyone ever mentioning it before (the article is rather old):
Macenski MJ, Cleary J, Thompson T. Effects on opioid-induced rate reductions by doxepin and bupropion. Pharmacology Biochemistry and Behavior. 1990;37(2):247–252. doi:10.1016/0091-3057(90)90329-G. I uploaded it here: http://db.tt/cjb8GjEg
Relevant parts of the article:
I thought this might be of interest to someone here.
Macenski MJ, Cleary J, Thompson T. Effects on opioid-induced rate reductions by doxepin and bupropion. Pharmacology Biochemistry and Behavior. 1990;37(2):247–252. doi:10.1016/0091-3057(90)90329-G. I uploaded it here: http://db.tt/cjb8GjEg
Relevant parts of the article:
Chronic daily doxepin administration significantly attenuated methadone-induced response rate reductions. Bupropion reduced the effect of the highest methadone dose, but this effect was mitigated by the development of opioid tolerance. Unlike bupropion, doxepin interfered with the development of opioid tolerance.... The effects of methadone during chronic daily doxepin or bupropion administration are shown in Fig. 2. The methadone dose-effect curve was shifted to the right during chronic doxepin under both VI parameters (top panels). No tolerance to methadone was apparent when the dose-effect relationship was reestablished following discontinuation of doxepin.... This attenuation of the rate-reducing effects of methadone cannot be accounted for by opioid tolerance, in fact, tolerance to methadone is diminished following doxepin treatment (see Figs. 2 and 3).
I thought this might be of interest to someone here.