Progress on the use of cannabinoids to treat schizo conditions

Boku_

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I remember reading online somewhere that labs in America were creating strains of medical cannabinoids that were hoped to be new treatment options for people experiencing schizo conditions as well as people diagnosed with PTSD and Dissociation and dissociative disorders.

Does anyone have news on the use of these cannabinoids?
 

Mafioso

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There is legitimate medical uses for cannabis and the various cannabinoids and terpenes contained, but it is largely over-hyped. It's a lot like the wine companies claiming that a glass of wine a day is healthy because of antioxidants and other things found in grapes. Cannabis is often touted as a cure-all as of late, with claims of curing cancer depression and other disease. There are also claims about how it can help with nearly every disease from physical ailments like cancer, arthritis, and diabetes to mental ailments like ptsd and panic attacks.

Most these claims are completely unsubstantiated unfortunately. There is a building body of research backed by things like peer-reviewed clinical studies, but a lot of these claims are so complex it's going to take a while to really understand what is going on.

As far as specific strains leading to specific medical uses... almost all hype or myth. When broken down on a chemical level, THC and CBD make up the bulk of the cannabinoids. THC, CBD and their various isomers have been isolated and studied fairly well, and this is where most the hype is centered around- THC heavy, CBD heavy, or fairly equal THC:CDB. Although there is potential for other cannabinoids to have therapeutic value when isolated, there isn't any reason I'm aware of to believe that there will be some highly valuable medicinal use or application.


I'm guessing what you probably heard of, since it's strain specific, is CBD heavy strains which had quite a bit of talk about it in the last 5 years. CBD in general is over-hyped. Yes there are medical uses and all that, it's been known that CBD and THC work synergistically in the body, and that CBD is significantly less effective without any THC.

Also, strain name is a very inaccurate way of determining cannabinoid content. Genetics will determine what the strain is capable of, but how it is grown will determine what it actually contains.
 

The Network

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CBD doesn't really treat schizophrenia at all... it just can help reduce the psychotic symptoms caused by THC when used together.
 

w01fg4ng

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The lack of information on medical marijuana is largely due to the scheduling of the cannabis plant. Many people don't even realize that CBD is still a schedule 1 drug. It's ignorance more than anything.

We can't study it if it is illegal. It's pretty simple really. If you want more peer reviewed sources on MMJ, we need to legalize it!


Until then, these peer reviewed sources (as it relates to the OP of course) are all I could come up with at the moment:

Among patients with schizophrenia, cannabis users had better cognitive functioning

PTSD symptoms were reduced by more than 75% in patients using cannabis

Here are 60 more peer reviewed studies on the value of MMJ
https://medicalmarijuana.procon.org/view.resource.php?resourceID=000884
 

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The lack of information on medical marijuana is largely due to the scheduling of the cannabis plant. Many people don't even realize that CBD is still a schedule 1 drug. It's ignorance more than anything.

We can't study it if it is illegal. It's pretty simple really. If you want more peer reviewed sources on MMJ, we need to legalize it!


Until then, these peer reviewed sources (as it relates to the OP of course) are all I could come up with at the moment:

Among patients with schizophrenia, cannabis users had better cognitive functioning

PTSD symptoms were reduced by more than 75% in patients using cannabis

Here are 60 more peer reviewed studies on the value of MMJ
https://medicalmarijuana.procon.org/view.resource.php?resourceID=000884
only CBD derived from regular weed, hemp CBD is legal everywhere.
 

madness00

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I just wanted to pop in and say, i have Bipolar Disorder with traits of Antisocial Personality Disorder, and weed helps tremendously with both. It brings me down from mania, it keeps me docile and non-aggressive, and keeps my spirits up in depressions. Hopefully these disorders (as well as shizo) will in time be added to the list of approved medical issues to obtain a medical card.
 

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I just wanted to pop in and say, i have Bipolar Disorder with traits of Antisocial Personality Disorder, and weed helps tremendously with both. It brings me down from mania, it keeps me docile and non-aggressive, and keeps my spirits up in depressions. Hopefully these disorders (as well as shizo) will in time be added to the list of approved medical issues to obtain a medical card.
Blatant placebo but glad it worked in one way or another.
 

Mafioso

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only CBD derived from regular weed, hemp CBD is legal everywhere.
not correct. chemically they are identical. Hemp derived cbd tends to be contaminated more because there is an abundance of cheap Chinese imported cbd. Chemically one is not superior to the other though.

CBD alone tends to be fairly ineffective from what I understand. If consumed orally, pure CBD needs a very high dose to be effective, something like 10-20mg per kg of body weight. However, when combined with thc it becomes effective for most with only 2.5mg thc and 2.5mg cbd. This is reported by Dr. Ethan Russo. Also, GWpharma just recently came out with a seizure medication called epidolex, which is dosed at 10-20mg per kg of body weight.

I'd recommend you check out Brandon Allen's IG page(link) if you are interested in this kind of stuff. He recently pointed out that there actually isn't a lacking of evidence and peer-reviewed studies about cannabis. If you search the US National Library of Medicine, you will find over 18,000 results(pubmed. You can use http://sci-hub.tw/ to access published studies that are not free. Other countries like Spain and Isreal have not had prohibitions on studying the plant either. I'm sure there is still a lot of be learned and discovered, but it isn't some highly mystical plant as often portrayed.

All medications have side effects which define the therapeutic value(positive vs negative effects). Cannabis is known to have some in particular that can make something like bipolar worse. "...the consumption of cannabis has been associated with increased risk of psychosis in adolescents, and may be associated with an increased risk for developing bipolar disorder and anxiety disorders." www.ncbi.nlm.nih.gov/pubmed/30055217
 
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SheWasLvL18

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^I've heard that we know more about THC than alcohol in terms of how they interact with the body. I think the reasoning was because alcohol impacts multiple areas of the brain and sometimes at levels below detection
 

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not correct. chemically they are identical. Hemp derived cbd tends to be contaminated more because there is an abundance of cheap Chinese imported cbd. Chemically one is not superior to the other though.

CBD alone tends to be fairly ineffective from what I understand. If consumed orally, pure CBD needs a very high dose to be effective, something like 10-20mg per kg of body weight. However, when combined with thc it becomes effective for most with only 2.5mg thc and 2.5mg cbd. This is reported by Dr. Ethan Russo. Also, GWpharma just recently came out with a seizure medication called epidolex, which is dosed at 10-20mg per kg of body weight.

I'd recommend you check out Brandon Allen's IG page(link) if you are interested in this kind of stuff. He recently pointed out that there actually isn't a lacking of evidence and peer-reviewed studies about cannabis. If you search the US National Library of Medicine, you will find over 18,000 results(pubmed. You can use http://sci-hub.tw/ to access published studies that are not free. Other countries like Spain and Isreal have not had prohibitions on studying the plant either. I'm sure there is still a lot of be learned and discovered, but it isn't some highly mystical plant as often portrayed.

All medications have side effects which define the therapeutic value(positive vs negative effects). Cannabis is known to have some in particular that can make something like bipolar worse. "...the consumption of cannabis has been associated with increased risk of psychosis in adolescents, and may be associated with an increased risk for developing bipolar disorder and anxiety disorders." www.ncbi.nlm.nih.gov/pubmed/30055217
Depends on what you're using it for. It only really needs a high dose for anxiolytic effects.
 

Mafioso

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It is possible. Alcohol is fairly complex because it permeates every cell of the body, so every organ is impacted. Another big thing that makes alcohol dangerous and difficult to understand is that it affects digestion, so a lot of the diseases are slow and degenerative. Knowledge and science are progressive, they will always grow with our understanding.

I think the disconnect is between mainstream culture in some countries and the research. A lot of this information is specialized, so it isn't taught in general science or medical nor has it been a required set of knowledge by the medical field in the past. There were no medications using cannabis because all cannabis use was illegal. Addictions specialist were aware of it and a lot of the information on it- but mostly just about the negative impacts of THC abuse.
 

Mafioso

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Depends on what you're using it for. It only really needs a high dose for anxiolytic effects.
What are you saying it is useful for at low doses?

There is a seizure medication on the market dosed at 10-20mg per kg of body weight a day per dose, but again, this is oral dosing.

As far as I'm aware, there is no information backing up low oral doses of CBD being more effective than placebo.
 
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