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Opioids Piracetam is prescribed for RLS in EU, would it work for opiated wd RLS?

M

mike.vick

Bluelighter
Joined
Aug 24, 2011
Messages
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Apparently, piracetam is prescribed for RLS in the UK. Would be effective for opiate withdrawal related RLS? You think? It is very inexpensive and I have some because I use it frequently for memory enhancement in my nootropic handful.
 
Would love to hear from sekio or someone on this topic. I'm surprised I had never heard anything about this.
 
Also surprised I've never heard anything about this but I imagine it would help, only makes sense.
 
On my mobile so can't elaborate effectively however I always was under the impression that opioid-induced RLS was due to a hypodopaminergic condition not related to ACh. Not sure how this mechanism would work on DA.
 
pinpoint said:
On my mobile so can't elaborate effectively however I always was under the impression that opioid-induced RLS was due to a hypodopaminergic condition not related to ACh. Not sure how this mechanism would work on DA.
Click to expand...
Activation of the ACh receptors causes a dopamine release. This is the reason why ciggarettes are addictive, nicotine is a N-ACh receptor agonist. I dont think piracetam would work well for restless legs though. It does raise levels of acetylcholine in the synapses but it can't be by much, it doesn't really have psychoactive effects.

I have RLS even without going through opiate withdrawal sometimes.

Restless leg syndrome is thought to be caused by low dopamine levels in the synapses. I've tried the dopamine agonist Requip (ropinirole) which binds to the dopamine receptors in the body and it didnt help at all.

Gabapentin is another medication prescribed for RLS. It worked well for me and helped me a little during withdrawal. You shouldn't have a problem getting gabapentin from a doctor. Also benzodiazepines can be prescribed and as a last resort opiates can be prescribed. Opiates work the best for treating RLS but obviously there's a pretty nasty side effect.

Nothing is going to completely take it away during bad opiate withdrawal. I was getting 100mg of Librium, a benzo, in jail & I still couldn't sit still. I was pacing & rocking back & forth for like the whole time I was there until I got bailed out for $50,000 4 days later. I was withdrawaling off of 30-50 bags a day of heroin lol.


Ropinirole
 
Edit: Okay https://books.google.com/books?id=v...=onepage&q=piracetam opiate myoclonus&f=false

This book lists piracetam under first-line treatment and, regarding myoclonus, says this: "The most effective drugs are clonazepam (4-10mg per day), sodium valproate (250-4500mg per day), and piracetam (10-24g per day)."

That is .63 cents- $1.30 per day, very affordable.

That being said it goes on to say that gabapentin is the most effect for opiate related myoclonus. But I have hope for piracetam, it is a cyclic derivative of gaba.

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Tons of stuff on google scholar about piracetam and myoclonus, though the dose is high ( ~24.0g/day).

http://scholar.google.com/scholar?q=piracetam+myoclonus&btnG=&hl=en&as_sdt=0%2C6

http://onlinelibrary.wiley.com/doi/10.1002/mds.870110615/abstract
http://jnnp.bmj.com/content/64/3/344.short
 
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