Hmm, it seems to very, but for a first time I'd recommend 100mg oral (note, oral route has really low BA probably), most people like plugging best for this one, and 300 or 400mg plugged is supposed to get you a more entheogenic, hole-like state. I've never tried plugging though. I usually use an initial oral dose of ~150mg plus a booster dose about 2 hours in when the first one has just come up, booster is usually snorted, but I'm trying vaping it, booster about the size of the first dose. There's both the freebase and hcl going around, the former being water insoluble (and ethonal insoluble), I have the base it seems so I haven't tried shooting it. Due to the dosage, this is kinda pricey for an RC.