Cyanoide
Bluelighter
- Joined
- Apr 22, 2011
- Messages
- 1,398
What do you think about Rick Strassman and his theories about DMT? I bought his book "DMT - The Spirit Molecule" (you may probably know about the documentary based on his book and research http://www.imdb.com/title/tt1340425/ I think the documentary is more fascinating in some ways than the book because it gives faces to the subjects). I was actually mainly interested in bying TiHKAL and PiHKAL (but got Strassman's book together with the two for almost free).
I disagree with some of his opinions and conclusions, but it's nevertheless an interesting book. One thing I'm a bit unsure of is Strassmann's theory that e.g. experiences of alien abduction actually are the result of a massive release of DMT from the brain. What could cause such a massive, spontaneous release of DMT from the brain? Are there any scientific articles on how much DMT actually occurs in humans naturally? Is there enough DMT naturally in the human brain to induce a breakthrough experience?
Oh, regarding TiHKAL. I'm aware new tryptamines are being synthesized, however Shulgin hasn't included any synthesis or qualitative comments about 4-Acetoxys. Why? I'm not a chemist nor a pharmacologist but do understand Hydroxy compounds in theory are metabolites of Acetoxys (or was it vice-versa?). The qualitative difference between many Hydroxys and Acetoxys is hardly noticeable, at all. Say, 4-AcO-DPT and 4-HO-DPT. The latter is a bit more potent and has a sligtly faster onset, but qualitatively I cannot distinguish between them otherwise. However, IME there are quite noticeable differences with e.g. 4-AcO-DMT and 4-HO-DMT. The former is more sedating and has a different bodyload than the latter. Similarities, yes, many, but they don't feel the same.
Please don't write a too complicated answer I'm just in the beginning phase of learning about more advanced pharmacology regarding tryptamines (and psychoactive drugs in general). Having studied social sciences (sociology, anthropology and political science) this is really new territory for me.
Edit: On a side note, I would really like to try ETH-LAD at some point in my life. I doubt I'll ever get my hands on it though. I also have some plans for a pharmahuasca trip in the future. The time is not ready for it yet though.
I disagree with some of his opinions and conclusions, but it's nevertheless an interesting book. One thing I'm a bit unsure of is Strassmann's theory that e.g. experiences of alien abduction actually are the result of a massive release of DMT from the brain. What could cause such a massive, spontaneous release of DMT from the brain? Are there any scientific articles on how much DMT actually occurs in humans naturally? Is there enough DMT naturally in the human brain to induce a breakthrough experience?
Oh, regarding TiHKAL. I'm aware new tryptamines are being synthesized, however Shulgin hasn't included any synthesis or qualitative comments about 4-Acetoxys. Why? I'm not a chemist nor a pharmacologist but do understand Hydroxy compounds in theory are metabolites of Acetoxys (or was it vice-versa?). The qualitative difference between many Hydroxys and Acetoxys is hardly noticeable, at all. Say, 4-AcO-DPT and 4-HO-DPT. The latter is a bit more potent and has a sligtly faster onset, but qualitatively I cannot distinguish between them otherwise. However, IME there are quite noticeable differences with e.g. 4-AcO-DMT and 4-HO-DMT. The former is more sedating and has a different bodyload than the latter. Similarities, yes, many, but they don't feel the same.
Please don't write a too complicated answer I'm just in the beginning phase of learning about more advanced pharmacology regarding tryptamines (and psychoactive drugs in general). Having studied social sciences (sociology, anthropology and political science) this is really new territory for me.
Edit: On a side note, I would really like to try ETH-LAD at some point in my life. I doubt I'll ever get my hands on it though. I also have some plans for a pharmahuasca trip in the future. The time is not ready for it yet though.
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