- May 24, 2008
You have 3 different posts for 4-Methyl-PCP, one is just as if not more potent, one is inactive, and the other is less active.
2-oxo is not mandatory to have a dissociative anesthetic, that's clear. There's a simple explanation why such works are done with comparison to ketamine - since it's introduction in human use there was no drug manufactured to replace it so it's inevitable to include it as an example while searching for other anesthetics being phencyclidine analogs. Anyway, 2-oxo seems to be a key in augmenting sedative action as it's seen not only in ketamine but also in tiletamine. Actually, a substituent on orto position on phenyl ring in ketamine probably plays a bigger role in analgesia/anesthesia and 2-oxo is good to make suitable doses for use higher. It does its job in medicine.I am trying to figure out if Ketamine is that out-of-this-world (no pun) unique in terms of SARs or if there is some kind of pattern, as I and several others seem to agree that simply sticking a 2-Keto group doesn't make a drug ketamine-like (methoxetamine and 2-keto-PCE both had more in common with PCP than they did with K).