Partial vs full benzodiazepine agonists

[Memantine]

Is there any list that ays what benzodiazepines are partial and what benzodiazepines are full agonists?

I am curious because partial agonists are less likely to cause tolerance and dependence.

 

[sigmond]

site will not allow me to post more than one article at the moment; anyway, try searching for: GABAA receptor partial agonists and antagonists: structure, binding mode, and pharmacology.

Several BZD site partial or subtype selective compounds, including bretazenil, abecarnil, or alpidem, have been developed as anxioselective anxiolytic drugs, but epilepsy was not a target indication for such compounds. More recently, the imidazolone derivatives imepitoin ELB138 and ELB139 were shown to act as low-affinity partial agonists at the BZD site of the GABAA receptor, and imepitoin was developed for the treatment of epilepsy.

http://www.ncbi.nlm.nih.gov/pubmed/24357084