Don't the side effects fade away after some time?Now, I have never taken the old non-selective irreversible MAOIs(and never will), but I have taken clomipramine. There is a reason why this drug is not prescribed often, and that is because it is really fucking powerful and nasty. A few hours after popping 25 miligrams, it hit me like a freigh train. Imagine the most emotionally relaxed and comfortable feeling ever, mixed with an intense feeling of physical energy and desire to move around, severe nausea and constipation and being completely unable to piss or shit no matter what. Yeah, nasty stuff. I took it for only 5 days and by the fifth day I was the happiest I've ever been in my life in a "I don't give a damn about mine or anyone else's problems" way. But not drowsy, but actually very energetic and full of vigour. Yeah,it was a nice experience,but the side effects are really nasty. I'll just leave this one for people that want to kill themselves.
Sure, but they never go away completely. More like your body adapts to restore homeostatic balance. The problem with clomipramine is that it is a tricyclic, and tricyclics are potent antagonists of the muscarinic acetylcholine receptors. Long-term users of tricyclics have statistically higher levels of dementia in old age because acetylcholine is essential for memory formation and fluid thought. They are "dumb drugs". Now, if you are suicidally depressed it doesen't matter if you might become senile 30 or 40 years down the road, as you have the more pressing issue of not blowing your brains out. In fact, one of the reasons why tricyclics are more effective for serious depression than the SSRIs is because they are anti-cholinergics. Stimulation of muscarinic receptors causes agitation and depression. One of the most serious long-term effects of people that survived poisoning by sarin, VX and other nerve agents is a severe depression that is not amenable to any sort of treatment. Antagomnism of AC receptors adds another dimension to the antidepressant effect of clomipramine besides it's highly potent inhibition of the reuptake of both serotonin and norepinephrine.Don't the side effects fade away after some time?